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- W2891944098 abstract "Background: In recent decades, natural products are an important source of chemotherapeutics as more than half of the effective cancer drugs can be traced to natural origins. Objective: Moreover, the modification of natural products is one of the most common and fruitful approaches to obtain novel therapeutic agents in medicinal chemistry. Method: Continuing with a research project based on the support of Moroccan plant resources. we report herein the use of α-isocostic acid extracted in enantiomerically pure form from Dittrichia viscosa as a convenient starting material for the synthesis of new eudesmane derivatives. Results: Novel spiro derivatives with a natural scaffold were prepared. Spiro-isoxazolidine derivatives were generated on the exocyclic double bond adjacent to the ester α,β-unsaturated function by 1,3-dipolar cycloaddition of methyl α-isocostate 1 derived from sesquiterpenic isocostic acid, with nitrones 2. Conclusion: This procedure allowed us to generate enantiomerically pure spiro compounds in one diastereoisomer form with a limited number of steps. These compounds were fully characterized by spectroscopic methods." @default.
- W2891944098 created "2018-09-27" @default.
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- W2891944098 date "2019-11-15" @default.
- W2891944098 modified "2023-10-18" @default.
- W2891944098 title "Synthesis of Spiro-Isoxazolidine Derivatives of Methyl α-Isocostate" @default.
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- W2891944098 doi "https://doi.org/10.2174/2210315508666180910124812" @default.
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