FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891947585> ?p ?o ?g. }

• W2891947585 endingPage "524" @default.
• W2891947585 startingPage "516" @default.
• W2891947585 abstract "Several studies indicate that ketamine has rapid antidepressant effects in patients with treatment-resistant depression (TRD). The extent to which repeated doses of ketamine (versus placebo) reduce depression in the short and long term among outpatients with TRD and chronic, current suicidal ideation remains unknown.Twenty-six medicated outpatients with severe major depressive disorder with current, chronic suicidal ideation were randomized in a double-blind fashion to six ketamine infusions (0.5 mg/kg over 45 minutes) or saline placebo over three weeks. Depression and suicidal ideation were assessed at baseline, 240 min post-infusion, and during a three-month follow-up phase.During the infusion phase, there was no differences in depression severity or suicidal ideation between placebo and ketamine (p = 0.47 and p = 0.32, respectively). At the end of the infusion phase, two patients in the ketamine group and one in the placebo group met criteria for remission of depression. At three-month follow-up, two patients in each group met criteria for remission from depression.Limitations include the small sample size, uncontrolled outpatient medication regimens, and restriction to outpatients, which may have resulted in lower levels of suicidal ideation than would be seen in emergency or inpatient settings.Repeated, non-escalating doses of ketamine did not outperform placebo in this double-blind, placebo controlled study of patients with severe TRD and current, chronic suicidal ideation. This result may support our previously published open-label data that, in this severely and chronically ill outpatient population, the commonly used dose of 0.5 mg/kg is not sufficient." @default.
• W2891947585 created "2018-09-27" @default.
• W2891947585 creator A5000964073 @default.
• W2891947585 creator A5018195329 @default.
• W2891947585 creator A5021285403 @default.
• W2891947585 creator A5029249140 @default.
• W2891947585 creator A5030321614 @default.
• W2891947585 creator A5045602410 @default.
• W2891947585 creator A5046621609 @default.
• W2891947585 creator A5063811512 @default.
• W2891947585 creator A5068011519 @default.
• W2891947585 creator A5072327575 @default.
• W2891947585 creator A5082058707 @default.
• W2891947585 creator A5082317510 @default.
• W2891947585 creator A5083798866 @default.
• W2891947585 creator A5084024326 @default.
• W2891947585 creator A5084949673 @default.
• W2891947585 creator A5088922500 @default.
• W2891947585 date "2019-01-01" @default.
• W2891947585 modified "2023-09-29" @default.
• W2891947585 title "Repeat-dose ketamine augmentation for treatment-resistant depression with chronic suicidal ideation: A randomized, double blind, placebo controlled trial" @default.
• W2891947585 cites W1865092458 @default.
• W2891947585 cites W1877280491 @default.
• W2891947585 cites W1969010498 @default.
• W2891947585 cites W1976396510 @default.
• W2891947585 cites W2005055479 @default.
• W2891947585 cites W2033541113 @default.
• W2891947585 cites W2097857685 @default.
• W2891947585 cites W2098750661 @default.
• W2891947585 cites W2103255996 @default.
• W2891947585 cites W2106636235 @default.
• W2891947585 cites W2107849028 @default.
• W2891947585 cites W2109334244 @default.
• W2891947585 cites W2109722108 @default.
• W2891947585 cites W2111663098 @default.
• W2891947585 cites W2111728433 @default.
• W2891947585 cites W2114613490 @default.
• W2891947585 cites W2117269242 @default.
• W2891947585 cites W2118815581 @default.
• W2891947585 cites W2126798879 @default.
• W2891947585 cites W2128918664 @default.
• W2891947585 cites W2137296158 @default.
• W2891947585 cites W2148083007 @default.
• W2891947585 cites W2273767197 @default.
• W2891947585 cites W2280943491 @default.
• W2891947585 cites W2330587564 @default.
• W2891947585 cites W2337400527 @default.
• W2891947585 cites W2339441338 @default.
• W2891947585 cites W2346471661 @default.
• W2891947585 cites W2460932141 @default.
• W2891947585 cites W2554643912 @default.
• W2891947585 cites W2604365947 @default.
• W2891947585 cites W2608506675 @default.
• W2891947585 cites W267891978 @default.
• W2891947585 cites W2771797851 @default.
• W2891947585 cites W2796940952 @default.
• W2891947585 doi "https://doi.org/10.1016/j.jad.2018.09.037" @default.
• W2891947585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30286416" @default.
• W2891947585 hasPublicationYear "2019" @default.
• W2891947585 type Work @default.
• W2891947585 sameAs 2891947585 @default.
• W2891947585 citedByCount "106" @default.
• W2891947585 countsByYear W28919475852018 @default.
• W2891947585 countsByYear W28919475852019 @default.
• W2891947585 countsByYear W28919475852020 @default.
• W2891947585 countsByYear W28919475852021 @default.
• W2891947585 countsByYear W28919475852022 @default.
• W2891947585 countsByYear W28919475852023 @default.
• W2891947585 crossrefType "journal-article" @default.
• W2891947585 hasAuthorship W2891947585A5000964073 @default.
• W2891947585 hasAuthorship W2891947585A5018195329 @default.
• W2891947585 hasAuthorship W2891947585A5021285403 @default.
• W2891947585 hasAuthorship W2891947585A5029249140 @default.
• W2891947585 hasAuthorship W2891947585A5030321614 @default.
• W2891947585 hasAuthorship W2891947585A5045602410 @default.
• W2891947585 hasAuthorship W2891947585A5046621609 @default.
• W2891947585 hasAuthorship W2891947585A5063811512 @default.
• W2891947585 hasAuthorship W2891947585A5068011519 @default.
• W2891947585 hasAuthorship W2891947585A5072327575 @default.
• W2891947585 hasAuthorship W2891947585A5082058707 @default.
• W2891947585 hasAuthorship W2891947585A5082317510 @default.
• W2891947585 hasAuthorship W2891947585A5083798866 @default.
• W2891947585 hasAuthorship W2891947585A5084024326 @default.
• W2891947585 hasAuthorship W2891947585A5084949673 @default.
• W2891947585 hasAuthorship W2891947585A5088922500 @default.
• W2891947585 hasConcept C118552586 @default.
• W2891947585 hasConcept C126322002 @default.
• W2891947585 hasConcept C139719470 @default.
• W2891947585 hasConcept C142724271 @default.
• W2891947585 hasConcept C162324750 @default.
• W2891947585 hasConcept C168563851 @default.
• W2891947585 hasConcept C190385971 @default.
• W2891947585 hasConcept C194828623 @default.
• W2891947585 hasConcept C204787440 @default.
• W2891947585 hasConcept C27081682 @default.
• W2891947585 hasConcept C2776641880 @default.
• W2891947585 hasConcept C2776867660 @default.
• W2891947585 hasConcept C2778709874 @default.

• next