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- W2891947662 abstract "8524 Background: This study aimed to investigate the survival difference between right-sided and left-sided pneumonectomy in stage I-IIIA NSCLC patients, and to further develop the best treatment strategies. Methods: Data from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute across 18 cancer registry sites in the United States were used for the present study. To avoid the bias between groups, we used an innovative propensity score matching analysis. Results: Stage I-IIIA NSCLC patients with pneumonectomy from 2004 to 2014 were included in this study. Of all 2,683 patients who received pneumonectomy, Overall survival (OS) (HR = 0.875, 95%CI: 0.793 to 0.967, P = 0.008) and cancer-specific survival (HR = 0.863, 95%CI: 0.771 to 0.965, P = 0.010) were significantly longer with left-sided pneumonectomy over right-sided pneumonectomy. After propensity score matching analysis for 2,050 patients, OS (HR = 0.858, 95%CI: 0.768 to 0.959, P = 0.007) and cancer-specific survival (HR = 0.847, 95%CI: 0.745 to 0.963, P = 0.011) were also significantly superior of left-sided compared with opposite-sided pneumonectomy. After matching procedure, among left-sided pneumonectomy patients, adjuvant therapy significantly prolonged OS (46 versus 30 months, HR = 1.458, 95%CI: 1.239 to 1.715, P < 0.001) and cancer-specific survival (67 versus 51 months, HR = 1.314, 95%CI: 1.093 to 1.579, P = 0.004) while among right-sided pneumonectomy patients, adjuvant therapy was not associated with cancer-specific survival benefit (46 versus 42 months, HR = 1.112, 95%CI: 0.933 to 1.325, P = 0.236). Subgroup analysis showed that adjuvant chemotherapy could significantly improve OS and cancer-specific survival for both sided pneumonectomy patients. But patients with right-sided pneumonectomy who received radiotherapy were associated with worse survival. Conclusions: Right-sided pneumonectomy was associated with worse survival compared with left-sided pneumonectomy. Adjuvant chemotherapy contribute significant benefit to patients who received both sided pneumonectomy, but radiotherapy worsened prognosis for right-sided pneumonectomy." @default.
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- W2891947662 date "2018-05-20" @default.
- W2891947662 modified "2023-09-25" @default.
- W2891947662 title "Evaluation of different treatment strategies between right-sided and left-sided pneumonectomy for stage I-IIIA non-small cell lung cancer patients." @default.
- W2891947662 doi "https://doi.org/10.1200/jco.2018.36.15_suppl.8524" @default.
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