Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891948360> ?p ?o ?g. }
- W2891948360 abstract "While pharmaceuticals are now routinely detected in aquatic environments, we know little of the biological activity their presence might provoke. It is estimated that nearly 40% of all marketed pharmaceuticals are G protein-coupled receptors (GPCRs) acting pharmaceuticals. Here, we applied an in-vitro assay, called the TGFα shedding assay, to measure the biological activities of GPCRs-acting pharmaceuticals present in effluents from municipal wastewater treatment plants in the United Kingdom (UK) and Japan from 2014 to 2016. The results indicated that compounds were present in the wastewater with antagonistic activities against angiotensin (AT1), dopamine (D2), adrenergic (β1), acetylcholine (M1), and histamine (H1) receptors in both countries. The most consistent and powerful antagonistic activity was against the H1, D2, and AT1 receptors at up to microgram-antagonist-equivalent quantity/L. Chemical analysis of the same UK samples was also conducted in parallel. Comparing the results of the bioassay with the chemical analysis indicated (1) the existence of other D2 or M1 receptor antagonists besides sulpiride (D2 antagonist) or pirenzepine (M1 antagonist) in wastewater and (2) that there might be a mixture effect between agonist and antagonistic activities against β1 receptor. GPCR-acting pharmaceuticals should be paid more attention in the environmental monitoring and toxicity testing in future studies." @default.
- W2891948360 created "2018-09-27" @default.
- W2891948360 creator A5000080749 @default.
- W2891948360 creator A5010161205 @default.
- W2891948360 creator A5014262355 @default.
- W2891948360 creator A5026275588 @default.
- W2891948360 creator A5030856028 @default.
- W2891948360 creator A5074186169 @default.
- W2891948360 creator A5076263126 @default.
- W2891948360 date "2018-09-28" @default.
- W2891948360 modified "2023-10-15" @default.
- W2891948360 title "Quantification of Pharmaceutical Related Biological Activity in Effluents from Wastewater Treatment Plants in UK and Japan" @default.
- W2891948360 cites W1836455575 @default.
- W2891948360 cites W1965064785 @default.
- W2891948360 cites W1965944952 @default.
- W2891948360 cites W1971503506 @default.
- W2891948360 cites W1979275879 @default.
- W2891948360 cites W1987677921 @default.
- W2891948360 cites W1996213169 @default.
- W2891948360 cites W2000780867 @default.
- W2891948360 cites W2013731232 @default.
- W2891948360 cites W2014116072 @default.
- W2891948360 cites W2016157492 @default.
- W2891948360 cites W2022479227 @default.
- W2891948360 cites W2026690875 @default.
- W2891948360 cites W2027426520 @default.
- W2891948360 cites W2029335938 @default.
- W2891948360 cites W2037766564 @default.
- W2891948360 cites W2039023381 @default.
- W2891948360 cites W2044816900 @default.
- W2891948360 cites W2045678348 @default.
- W2891948360 cites W2046674454 @default.
- W2891948360 cites W2050888498 @default.
- W2891948360 cites W2050986486 @default.
- W2891948360 cites W2053322034 @default.
- W2891948360 cites W2072339172 @default.
- W2891948360 cites W2076866060 @default.
- W2891948360 cites W2080217192 @default.
- W2891948360 cites W2087843592 @default.
- W2891948360 cites W2094514382 @default.
- W2891948360 cites W2131984758 @default.
- W2891948360 cites W2168007598 @default.
- W2891948360 cites W2168129859 @default.
- W2891948360 cites W2324046000 @default.
- W2891948360 cites W2344578960 @default.
- W2891948360 cites W2394562301 @default.
- W2891948360 cites W2498840793 @default.
- W2891948360 cites W2529533451 @default.
- W2891948360 cites W2544738886 @default.
- W2891948360 cites W2556718642 @default.
- W2891948360 cites W2588017779 @default.
- W2891948360 cites W2592847695 @default.
- W2891948360 cites W2597237470 @default.
- W2891948360 cites W2765843930 @default.
- W2891948360 cites W2782382515 @default.
- W2891948360 cites W2786571932 @default.
- W2891948360 cites W2788898240 @default.
- W2891948360 cites W2791991839 @default.
- W2891948360 cites W2793118582 @default.
- W2891948360 cites W2807103424 @default.
- W2891948360 cites W849599241 @default.
- W2891948360 doi "https://doi.org/10.1021/acs.est.8b03013" @default.
- W2891948360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30216714" @default.
- W2891948360 hasPublicationYear "2018" @default.
- W2891948360 type Work @default.
- W2891948360 sameAs 2891948360 @default.
- W2891948360 citedByCount "7" @default.
- W2891948360 countsByYear W28919483602019 @default.
- W2891948360 countsByYear W28919483602020 @default.
- W2891948360 countsByYear W28919483602022 @default.
- W2891948360 countsByYear W28919483602023 @default.
- W2891948360 crossrefType "journal-article" @default.
- W2891948360 hasAuthorship W2891948360A5000080749 @default.
- W2891948360 hasAuthorship W2891948360A5010161205 @default.
- W2891948360 hasAuthorship W2891948360A5014262355 @default.
- W2891948360 hasAuthorship W2891948360A5026275588 @default.
- W2891948360 hasAuthorship W2891948360A5030856028 @default.
- W2891948360 hasAuthorship W2891948360A5074186169 @default.
- W2891948360 hasAuthorship W2891948360A5076263126 @default.
- W2891948360 hasBestOaLocation W28919483602 @default.
- W2891948360 hasConcept C104488531 @default.
- W2891948360 hasConcept C116073593 @default.
- W2891948360 hasConcept C135285700 @default.
- W2891948360 hasConcept C170493617 @default.
- W2891948360 hasConcept C185592680 @default.
- W2891948360 hasConcept C18903297 @default.
- W2891948360 hasConcept C202751555 @default.
- W2891948360 hasConcept C2776885963 @default.
- W2891948360 hasConcept C2778938600 @default.
- W2891948360 hasConcept C2780806966 @default.
- W2891948360 hasConcept C39432304 @default.
- W2891948360 hasConcept C55493867 @default.
- W2891948360 hasConcept C86803240 @default.
- W2891948360 hasConcept C87717796 @default.
- W2891948360 hasConcept C94061648 @default.
- W2891948360 hasConcept C98274493 @default.
- W2891948360 hasConceptScore W2891948360C104488531 @default.
- W2891948360 hasConceptScore W2891948360C116073593 @default.
- W2891948360 hasConceptScore W2891948360C135285700 @default.
- W2891948360 hasConceptScore W2891948360C170493617 @default.