FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891965004> ?p ?o ?g. }

• W2891965004 endingPage "11" @default.
• W2891965004 startingPage "1" @default.
• W2891965004 abstract "Microbubbles magnify the acoustic pressure of low-intensity pulsed ultrasound (LIPUS) and may enhance its bioeffect for diagnostic and therapeutic purposes. This study compared the effect of this novel microbubble-mediated ultrasound (MUS) with that of the traditional LIPUS on osteogenesis and neovascularization in a rabbit model of steroid-associated osteonecrosis. We hypothesized that MUS might outweigh LIPUS on promoting osteogenesis and neovascularization in steroid-associated osteonecrosis. The bilateral femoral head necrosis was induced by lipopolysaccharide and methylprednisolone in the rabbits. The indices of bone mineral density (BMD), trabecular number, maximal loading strength, and mineral apposition rate were analyzed, demonstrating that the animal model of steroid-associated osteonecrosis was successfully established. Both the MUS group (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>G</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant=normal>M</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>) and the LIPUS group (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>G</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant=normal>L</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>) were insonated 20 min daily for six weeks. <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>G</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant=normal>M</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> received an extra intracapsular injection of microbubbles before insonation every other day. Fluorescence bone labeling, Micro-CT Analysis, biomechanical test, quantitative real-time PCR, Western blot analysis, and histological evaluation were performed for comparing <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>G</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant=normal>M</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> with <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>G</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant=normal>L</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>. The results demonstrated a 39% higher mineral apposition rate in <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>G</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant=normal>M</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> compared with <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>G</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant=normal>L</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>. The BMD and the maximal loading strength of femoral head of <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>G</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant=normal>M</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> increased by 4.3% and 27.8% compared to those of <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>G</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant=normal>L</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>, respectively. The mRNA and protein expression of BMP-2 and VEGF were also significantly higher in <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>G</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant=normal>M</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>. The number of blood vessels of <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>G</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant=normal>M</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> was 65% greater than that of <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M12><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=normal>G</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant=normal>L</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>. MUS is more potent than LIPUS in enhancing osteogenesis, neovascularization, and biomechanical strength of femoral head in the animal model of steroid-associated osteonecrosis. Without increasing the intensity of insonation or the risk of tissue damage, MUS is better for inhibiting the process of steroid-associated osteonecrosis." @default.
• W2891965004 created "2018-09-27" @default.
• W2891965004 creator A5040715442 @default.
• W2891965004 creator A5059747108 @default.
• W2891965004 creator A5069007676 @default.
• W2891965004 creator A5085733179 @default.
• W2891965004 date "2018-09-12" @default.
• W2891965004 modified "2023-10-16" @default.
• W2891965004 title "Microbubble-Mediated Ultrasound Outweighs Low-Intensity Pulsed Ultrasound on Osteogenesis and Neovascularization in a Rabbit Model of Steroid-Associated Osteonecrosis" @default.
• W2891965004 cites W145265202 @default.
• W2891965004 cites W1825487942 @default.
• W2891965004 cites W1969815103 @default.
• W2891965004 cites W1972339143 @default.
• W2891965004 cites W1977516200 @default.
• W2891965004 cites W1978432461 @default.
• W2891965004 cites W1991713030 @default.
• W2891965004 cites W1996016867 @default.
• W2891965004 cites W1998329077 @default.
• W2891965004 cites W2003810034 @default.
• W2891965004 cites W2005663238 @default.
• W2891965004 cites W2005676503 @default.
• W2891965004 cites W2007922867 @default.
• W2891965004 cites W2010933562 @default.
• W2891965004 cites W2028150366 @default.
• W2891965004 cites W2035830822 @default.
• W2891965004 cites W2043141235 @default.
• W2891965004 cites W2052524596 @default.
• W2891965004 cites W2053507933 @default.
• W2891965004 cites W2064417120 @default.
• W2891965004 cites W2064657535 @default.
• W2891965004 cites W2066749771 @default.
• W2891965004 cites W2070672521 @default.
• W2891965004 cites W2077848818 @default.
• W2891965004 cites W2114968619 @default.
• W2891965004 cites W2144321092 @default.
• W2891965004 cites W2146494391 @default.
• W2891965004 cites W2415977973 @default.
• W2891965004 cites W2590821097 @default.
• W2891965004 cites W4378363609 @default.
• W2891965004 doi "https://doi.org/10.1155/2018/4606791" @default.
• W2891965004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6157205" @default.
• W2891965004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30298135" @default.
• W2891965004 hasPublicationYear "2018" @default.
• W2891965004 type Work @default.
• W2891965004 sameAs 2891965004 @default.
• W2891965004 citedByCount "4" @default.
• W2891965004 countsByYear W28919650042019 @default.
• W2891965004 countsByYear W28919650042020 @default.
• W2891965004 countsByYear W28919650042021 @default.
• W2891965004 countsByYear W28919650042022 @default.
• W2891965004 crossrefType "journal-article" @default.
• W2891965004 hasAuthorship W2891965004A5040715442 @default.
• W2891965004 hasAuthorship W2891965004A5059747108 @default.
• W2891965004 hasAuthorship W2891965004A5069007676 @default.
• W2891965004 hasAuthorship W2891965004A5085733179 @default.
• W2891965004 hasBestOaLocation W28919650041 @default.
• W2891965004 hasConcept C11413529 @default.
• W2891965004 hasConcept C126838900 @default.
• W2891965004 hasConcept C143753070 @default.
• W2891965004 hasConcept C41008148 @default.
• W2891965004 hasConcept C71924100 @default.
• W2891965004 hasConceptScore W2891965004C11413529 @default.
• W2891965004 hasConceptScore W2891965004C126838900 @default.
• W2891965004 hasConceptScore W2891965004C143753070 @default.
• W2891965004 hasConceptScore W2891965004C41008148 @default.
• W2891965004 hasConceptScore W2891965004C71924100 @default.
• W2891965004 hasFunder F4320321001 @default.
• W2891965004 hasLocation W28919650041 @default.
• W2891965004 hasLocation W28919650042 @default.
• W2891965004 hasLocation W28919650043 @default.
• W2891965004 hasLocation W28919650044 @default.
• W2891965004 hasOpenAccess W2891965004 @default.
• W2891965004 hasPrimaryLocation W28919650041 @default.
• W2891965004 hasRelatedWork W1506200166 @default.
• W2891965004 hasRelatedWork W1995515455 @default.
• W2891965004 hasRelatedWork W2048182022 @default.
• W2891965004 hasRelatedWork W2080531066 @default.
• W2891965004 hasRelatedWork W2373416058 @default.
• W2891965004 hasRelatedWork W2748952813 @default.
• W2891965004 hasRelatedWork W2899084033 @default.
• W2891965004 hasRelatedWork W3031052312 @default.
• W2891965004 hasRelatedWork W3032375762 @default.
• W2891965004 hasRelatedWork W3108674512 @default.
• W2891965004 hasVolume "2018" @default.
• W2891965004 isParatext "false" @default.
• W2891965004 isRetracted "false" @default.
• W2891965004 magId "2891965004" @default.
• W2891965004 workType "article" @default.