Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891965944> ?p ?o ?g. }
- W2891965944 endingPage "7600" @default.
- W2891965944 startingPage "7590" @default.
- W2891965944 abstract "Nanoparticles are often targeted to receptors expressed on specific cells, but few receptors are (i) highly expressed on one cell type and (ii) involved in endocytosis. One unexplored alternative is manipulating an endocytic gene expressed on multiple cell types; an ideal gene would inhibit delivery to cell type A more than cell type B, promoting delivery to cell type B. This would require a commonly expressed endocytic gene to alter nanoparticle delivery in a cell type-dependent manner in vivo; whether this can occur is unknown. Based on its microenvironmental regulation, we hypothesized Caveolin 1 (Cav1) would exert cell type-specific effects on nanoparticle delivery. Fluorescence was not sensitive enough to investigate this question, and as a result, we designed a platform named QUANT to study nanoparticle biodistribution. QUANT is 108× more sensitive than fluorescence and can be multiplexed. By measuring how 226 lipid nanoparticles (LNPs) delivered nucleic acids to multiple cell types in vivo in wild-type and Cav1 knockout mice, we found Cav1 altered delivery in a cell-type specific manner. Cav1 knockout did not alter LNP delivery to lung and kidney macrophages but substantially reduced LNP delivery to Kupffer cells, which are liver-resident macrophages. These data suggest caveolin-mediated endocytosis of nanomedicines by macrophages varies with tissue type. These results suggest manipulating receptors expressed on multiple cell types can tune drug delivery." @default.
- W2891965944 created "2018-09-27" @default.
- W2891965944 creator A5016428318 @default.
- W2891965944 creator A5017275685 @default.
- W2891965944 creator A5036723734 @default.
- W2891965944 creator A5050948216 @default.
- W2891965944 creator A5059302377 @default.
- W2891965944 creator A5061869040 @default.
- W2891965944 creator A5081929582 @default.
- W2891965944 creator A5088341793 @default.
- W2891965944 date "2018-09-14" @default.
- W2891965944 modified "2023-10-18" @default.
- W2891965944 title "Modifying a Commonly Expressed Endocytic Receptor Retargets Nanoparticles in Vivo" @default.
- W2891965944 cites W111471251 @default.
- W2891965944 cites W1182506064 @default.
- W2891965944 cites W1844274376 @default.
- W2891965944 cites W187145417 @default.
- W2891965944 cites W1972476556 @default.
- W2891965944 cites W1977049975 @default.
- W2891965944 cites W1979283544 @default.
- W2891965944 cites W1986032553 @default.
- W2891965944 cites W2002050544 @default.
- W2891965944 cites W2003110090 @default.
- W2891965944 cites W2009178411 @default.
- W2891965944 cites W2010169605 @default.
- W2891965944 cites W2014509855 @default.
- W2891965944 cites W2016100345 @default.
- W2891965944 cites W2019613864 @default.
- W2891965944 cites W2042194227 @default.
- W2891965944 cites W2050411471 @default.
- W2891965944 cites W2056380758 @default.
- W2891965944 cites W2060221489 @default.
- W2891965944 cites W2061655961 @default.
- W2891965944 cites W2068807411 @default.
- W2891965944 cites W2069905396 @default.
- W2891965944 cites W2069981183 @default.
- W2891965944 cites W2071030419 @default.
- W2891965944 cites W2080718344 @default.
- W2891965944 cites W2089150369 @default.
- W2891965944 cites W2092201159 @default.
- W2891965944 cites W2098474946 @default.
- W2891965944 cites W2117911674 @default.
- W2891965944 cites W2118022632 @default.
- W2891965944 cites W2119046783 @default.
- W2891965944 cites W2123818367 @default.
- W2891965944 cites W2133772088 @default.
- W2891965944 cites W2133851039 @default.
- W2891965944 cites W2143743183 @default.
- W2891965944 cites W2155239981 @default.
- W2891965944 cites W2157963288 @default.
- W2891965944 cites W2157979200 @default.
- W2891965944 cites W2161744546 @default.
- W2891965944 cites W2161883784 @default.
- W2891965944 cites W2168897708 @default.
- W2891965944 cites W2172226098 @default.
- W2891965944 cites W2191292005 @default.
- W2891965944 cites W2233414233 @default.
- W2891965944 cites W2236822143 @default.
- W2891965944 cites W2401221324 @default.
- W2891965944 cites W2409181431 @default.
- W2891965944 cites W2416134335 @default.
- W2891965944 cites W2422307725 @default.
- W2891965944 cites W2479827938 @default.
- W2891965944 cites W2505614715 @default.
- W2891965944 cites W2515394036 @default.
- W2891965944 cites W2516557409 @default.
- W2891965944 cites W2547983352 @default.
- W2891965944 cites W2554387513 @default.
- W2891965944 cites W2586934391 @default.
- W2891965944 cites W2624068238 @default.
- W2891965944 cites W2734498030 @default.
- W2891965944 cites W2748490245 @default.
- W2891965944 cites W2749161757 @default.
- W2891965944 cites W2753865234 @default.
- W2891965944 cites W2757272801 @default.
- W2891965944 cites W2766959028 @default.
- W2891965944 cites W2786318872 @default.
- W2891965944 cites W2788471465 @default.
- W2891965944 cites W2791618607 @default.
- W2891965944 cites W2794420727 @default.
- W2891965944 cites W2808895931 @default.
- W2891965944 cites W2810909862 @default.
- W2891965944 cites W2883152153 @default.
- W2891965944 cites W2888555840 @default.
- W2891965944 doi "https://doi.org/10.1021/acs.nanolett.8b03149" @default.
- W2891965944 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6426696" @default.
- W2891965944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30216729" @default.
- W2891965944 hasPublicationYear "2018" @default.
- W2891965944 type Work @default.
- W2891965944 sameAs 2891965944 @default.
- W2891965944 citedByCount "31" @default.
- W2891965944 countsByYear W28919659442018 @default.
- W2891965944 countsByYear W28919659442019 @default.
- W2891965944 countsByYear W28919659442020 @default.
- W2891965944 countsByYear W28919659442021 @default.
- W2891965944 countsByYear W28919659442022 @default.
- W2891965944 countsByYear W28919659442023 @default.
- W2891965944 crossrefType "journal-article" @default.