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• W2891966248 abstract "Blood-brain barrier (BBB) breakdown has been hypothesized to play a key role in the onset and progression of Alzheimer's disease (AD). However, the question of whether AD itself contributes to loss of BBB integrity is still uncertain, as many in-vivo studies have failed to detect signs of AD-related BBB breakdown. We hypothesize AD-related BBB damage is subtle, and that these negative results arise from a lack of measurement sensitivity. With the aim of developing a more sensitive measure of BBB breakdown, we have designed a novel MRI scanning protocol to quantify the trans-BBB exchange of endogenous water. Using this method, we detect increased BBB water permeability in a rat model of AD that is associated with reduced expression of the tight junction protein occludin. BBB permeability to MRI contrast agent, assessed using dynamic contrast-enhanced (DCE)-MRI, did not differ between transgenic and wild-type animals and was uncorrelated with occludin expression. Our data supports the occurrence of AD-related BBB breakdown, and indicates that such BBB pathology is subtle and may be undetectable using existing ‘tracer leakage’ methods. Our validated water-exchange MRI method provides a new powerful tool with which to study BBB damage in-vivo." @default.
• W2891966248 created "2018-09-27" @default.
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• W2891966248 date "2019-01-01" @default.
• W2891966248 modified "2023-09-30" @default.
• W2891966248 title "Water-exchange MRI detects subtle blood-brain barrier breakdown in Alzheimer's disease rats" @default.
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• W2891966248 doi "https://doi.org/10.1016/j.neuroimage.2018.09.030" @default.
• W2891966248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30219292" @default.
• W2891966248 hasPublicationYear "2019" @default.
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