Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891969901> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2891969901 abstract "Background Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can detect subtle blood-brain barrier (BBB) permeability. We developed a protocol and conducted experiments to validate the technique. Methods 12 subjects with relapsing-remitting multiple sclerosis (RRMS) and 13 controls were recruited. Whole-brain 3D DCE-MRI at 3 Tesla was used to calculate the influx constant Ki (Patlak method). Values were derived for manual regions of interest (ROI) as well as segmented tissue masks. In controls, cerebral blood volume (CBV) was measured in grey and white matter. Results In RRMS, Ki in visibly-enhancing lesions was significantly higher than in normal-appearing white matter (NAWM) (p=0.002). Ki in NAWM was significantly higher in RRMS than controls, by both ROI (p=0.014) and segmentation (p=0.019) methods. In controls, Ki was significantly higher in grey than white matter (p=0.001). CBV (and therefore vascular surface area) was also significantly higher in grey matter (p=0.005), with a mean ratio of 1.9. Conclusions Our method produces results in line with the expected behaviour of a BBB permeability marker, and the grey/white matter CBV ratio is in agreement with the histologically-established value." @default.
- W2891969901 created "2018-09-27" @default.
- W2891969901 creator A5013602639 @default.
- W2891969901 creator A5037754431 @default.
- W2891969901 creator A5038952654 @default.
- W2891969901 creator A5049683085 @default.
- W2891969901 creator A5065473203 @default.
- W2891969901 creator A5066999939 @default.
- W2891969901 date "2018-09-13" @default.
- W2891969901 modified "2023-10-14" @default.
- W2891969901 title "WED 168 Blood-brain barrier imaging with dynamic contrast-enhanced mri" @default.
- W2891969901 doi "https://doi.org/10.1136/jnnp-2018-abn.76" @default.
- W2891969901 hasPublicationYear "2018" @default.
- W2891969901 type Work @default.
- W2891969901 sameAs 2891969901 @default.
- W2891969901 citedByCount "0" @default.
- W2891969901 crossrefType "journal-article" @default.
- W2891969901 hasAuthorship W2891969901A5013602639 @default.
- W2891969901 hasAuthorship W2891969901A5037754431 @default.
- W2891969901 hasAuthorship W2891969901A5038952654 @default.
- W2891969901 hasAuthorship W2891969901A5049683085 @default.
- W2891969901 hasAuthorship W2891969901A5065473203 @default.
- W2891969901 hasAuthorship W2891969901A5066999939 @default.
- W2891969901 hasConcept C118552586 @default.
- W2891969901 hasConcept C126838900 @default.
- W2891969901 hasConcept C142724271 @default.
- W2891969901 hasConcept C143409427 @default.
- W2891969901 hasConcept C19609008 @default.
- W2891969901 hasConcept C2778013878 @default.
- W2891969901 hasConcept C2780640218 @default.
- W2891969901 hasConcept C2781192897 @default.
- W2891969901 hasConcept C2982720008 @default.
- W2891969901 hasConcept C2989005 @default.
- W2891969901 hasConcept C71924100 @default.
- W2891969901 hasConceptScore W2891969901C118552586 @default.
- W2891969901 hasConceptScore W2891969901C126838900 @default.
- W2891969901 hasConceptScore W2891969901C142724271 @default.
- W2891969901 hasConceptScore W2891969901C143409427 @default.
- W2891969901 hasConceptScore W2891969901C19609008 @default.
- W2891969901 hasConceptScore W2891969901C2778013878 @default.
- W2891969901 hasConceptScore W2891969901C2780640218 @default.
- W2891969901 hasConceptScore W2891969901C2781192897 @default.
- W2891969901 hasConceptScore W2891969901C2982720008 @default.
- W2891969901 hasConceptScore W2891969901C2989005 @default.
- W2891969901 hasConceptScore W2891969901C71924100 @default.
- W2891969901 hasLocation W28919699011 @default.
- W2891969901 hasOpenAccess W2891969901 @default.
- W2891969901 hasPrimaryLocation W28919699011 @default.
- W2891969901 hasRelatedWork W1964007754 @default.
- W2891969901 hasRelatedWork W1977321029 @default.
- W2891969901 hasRelatedWork W2002358084 @default.
- W2891969901 hasRelatedWork W2066572901 @default.
- W2891969901 hasRelatedWork W2081429148 @default.
- W2891969901 hasRelatedWork W2151651656 @default.
- W2891969901 hasRelatedWork W2381096987 @default.
- W2891969901 hasRelatedWork W2465676803 @default.
- W2891969901 hasRelatedWork W2471313541 @default.
- W2891969901 hasRelatedWork W2891969901 @default.
- W2891969901 isParatext "false" @default.
- W2891969901 isRetracted "false" @default.
- W2891969901 magId "2891969901" @default.
- W2891969901 workType "article" @default.