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• W2891970189 abstract "Myocardial perfusion imaging (MPI) is one of the most commonly performed investigations in nuclear medicine studies. Due to the physical properties of the positron emitter gallium-68 (68Ga) and its availability from 68Ge/68Ga generator, together with the well-known coordination chemistry, we have synthesized 68Ga-NOTA- and 68Ga-NODAGA-rhodamine conjugates using a straightforward and a one-step simple reaction. Radiochemical yields were greater than 95% (decay corrected), with total synthesis time of less than 30 min. Radiochemical purities were always greater than 98% as assessed by TLC and HPLC. These synthetic approaches hold considerable promise as simple method for 68Ga-rhodamine conjugates preparation, with high radiochemical yield and purity. Biodistribution studies in normal Fischer rats at 60 min post-injection, demonstrated significant (~3% ID/g) uptake and favorable biodistribution profile for 68Ga-NOTA-rhodamine over 68Ga-NODAGA-rhodamine conjugate. These results demonstrate that 68Ga-NOTA-rhodamine conjugate may be useful as probe for the PET evaluation of myocardial perfusion." @default.
• W2891970189 created "2018-09-27" @default.
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• W2891970189 date "2019-02-01" @default.
• W2891970189 modified "2023-09-26" @default.
• W2891970189 title "Synthesis of novel gallium-68 labeled rhodamine: A potential PET myocardial perfusion agent" @default.
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• W2891970189 doi "https://doi.org/10.1016/j.apradiso.2018.09.009" @default.
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