FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891973735> ?p ?o ?g. }

• W2891973735 endingPage "189" @default.
• W2891973735 startingPage "178" @default.
• W2891973735 abstract "Metabolic alterations are increasingly recognized as important novel anti‐cancer targets. Among several regulators of metabolic alterations, fructose 2,6 bisphosphate (F2,6BP) is a critical glycolytic regulator. Inhibition of the active form of PFKFB3 ser461 using a novel inhibitor, PFK158 resulted in reduced glucose uptake, ATP production, lactate release as well as induction of apoptosis in gynecologic cancer cells. Moreover, we found that PFK158 synergizes with carboplatin (CBPt) and paclitaxel (PTX) in the chemoresistant cell lines, C13 and HeyA8MDR but not in their chemosensitive counterparts, OV2008 and HeyA8, respectively. We determined that PFK158‐induced autophagic flux leads to lipophagy resulting in the downregulation of cPLA2, a lipid droplet (LD) associated protein. Immunofluorescence and co‐immunoprecipitation revealed colocalization of p62/SQSTM1 with cPLA2 in HeyA8MDR cells uncovering a novel pathway for the breakdown of LDs promoted by PFK158. Interestingly, treating the cells with the autophagic inhibitor bafilomycin A reversed the PFK158‐mediated synergy and lipophagy in chemoresistant cells. Finally, in a highly metastatic PTX‐resistant in vivo ovarian mouse model, a combination of PFK158 with CBPt significantly reduced tumor weight and ascites and reduced LDs in tumor tissue as seen by immunofluorescence and transmission electron microscopy compared to untreated mice. Since the majority of cancer patients will eventually recur and develop chemoresistance, our results suggest that PFK158 in combination with standard chemotherapy may have a direct clinical role in the treatment of recurrent cancer." @default.
• W2891973735 created "2018-09-27" @default.
• W2891973735 creator A5001092701 @default.
• W2891973735 creator A5001224491 @default.
• W2891973735 creator A5015530177 @default.
• W2891973735 creator A5017630308 @default.
• W2891973735 creator A5022234384 @default.
• W2891973735 creator A5030683638 @default.
• W2891973735 creator A5030976623 @default.
• W2891973735 creator A5031503097 @default.
• W2891973735 creator A5033657210 @default.
• W2891973735 creator A5041765132 @default.
• W2891973735 creator A5066134173 @default.
• W2891973735 creator A5066266457 @default.
• W2891973735 creator A5069570379 @default.
• W2891973735 creator A5074821486 @default.
• W2891973735 creator A5086165685 @default.
• W2891973735 creator A5090077537 @default.
• W2891973735 creator A5091001750 @default.
• W2891973735 date "2018-10-30" @default.
• W2891973735 modified "2023-10-07" @default.
• W2891973735 title "Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers" @default.
• W2891973735 cites W1599317260 @default.
• W2891973735 cites W1706150252 @default.
• W2891973735 cites W1886753592 @default.
• W2891973735 cites W1918457714 @default.
• W2891973735 cites W1964725493 @default.
• W2891973735 cites W1965211403 @default.
• W2891973735 cites W1974152703 @default.
• W2891973735 cites W1990253071 @default.
• W2891973735 cites W1992606175 @default.
• W2891973735 cites W2000081372 @default.
• W2891973735 cites W2007505836 @default.
• W2891973735 cites W2011925487 @default.
• W2891973735 cites W2014349355 @default.
• W2891973735 cites W2020681708 @default.
• W2891973735 cites W2021153743 @default.
• W2891973735 cites W2024883161 @default.
• W2891973735 cites W2041486030 @default.
• W2891973735 cites W2062532881 @default.
• W2891973735 cites W2068347855 @default.
• W2891973735 cites W2085352402 @default.
• W2891973735 cites W2091049385 @default.
• W2891973735 cites W2095985189 @default.
• W2891973735 cites W2096439168 @default.
• W2891973735 cites W2097259163 @default.
• W2891973735 cites W2110839026 @default.
• W2891973735 cites W2115954319 @default.
• W2891973735 cites W2117594441 @default.
• W2891973735 cites W2120263037 @default.
• W2891973735 cites W2122487766 @default.
• W2891973735 cites W2127158392 @default.
• W2891973735 cites W2138590199 @default.
• W2891973735 cites W2143182558 @default.
• W2891973735 cites W2158520870 @default.
• W2891973735 cites W2164548123 @default.
• W2891973735 cites W2170776802 @default.
• W2891973735 cites W2171112998 @default.
• W2891973735 cites W2235523093 @default.
• W2891973735 cites W2265836483 @default.
• W2891973735 cites W2284128798 @default.
• W2891973735 cites W2508519535 @default.
• W2891973735 cites W2509675079 @default.
• W2891973735 cites W2586287271 @default.
• W2891973735 cites W2604197619 @default.
• W2891973735 doi "https://doi.org/10.1002/ijc.31868" @default.
• W2891973735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6261695" @default.
• W2891973735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30226266" @default.
• W2891973735 hasPublicationYear "2018" @default.
• W2891973735 type Work @default.
• W2891973735 sameAs 2891973735 @default.
• W2891973735 citedByCount "92" @default.
• W2891973735 countsByYear W28919737352018 @default.
• W2891973735 countsByYear W28919737352019 @default.
• W2891973735 countsByYear W28919737352020 @default.
• W2891973735 countsByYear W28919737352021 @default.
• W2891973735 countsByYear W28919737352022 @default.
• W2891973735 countsByYear W28919737352023 @default.
• W2891973735 crossrefType "journal-article" @default.
• W2891973735 hasAuthorship W2891973735A5001092701 @default.
• W2891973735 hasAuthorship W2891973735A5001224491 @default.
• W2891973735 hasAuthorship W2891973735A5015530177 @default.
• W2891973735 hasAuthorship W2891973735A5017630308 @default.
• W2891973735 hasAuthorship W2891973735A5022234384 @default.
• W2891973735 hasAuthorship W2891973735A5030683638 @default.
• W2891973735 hasAuthorship W2891973735A5030976623 @default.
• W2891973735 hasAuthorship W2891973735A5031503097 @default.
• W2891973735 hasAuthorship W2891973735A5033657210 @default.
• W2891973735 hasAuthorship W2891973735A5041765132 @default.
• W2891973735 hasAuthorship W2891973735A5066134173 @default.
• W2891973735 hasAuthorship W2891973735A5066266457 @default.
• W2891973735 hasAuthorship W2891973735A5069570379 @default.
• W2891973735 hasAuthorship W2891973735A5074821486 @default.
• W2891973735 hasAuthorship W2891973735A5086165685 @default.
• W2891973735 hasAuthorship W2891973735A5090077537 @default.
• W2891973735 hasAuthorship W2891973735A5091001750 @default.
• W2891973735 hasBestOaLocation W28919737351 @default.
• W2891973735 hasConcept C104317684 @default.

• next