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- W2891979812 startingPage "fetalneonatal" @default.
- W2891979812 abstract "Objective Hyperglycaemia is common in very preterm infants and is associated with adverse outcomes. Preventing hyperglycaemia without increasing the risk of hypoglycaemia is difficult. Real time tracking with continuous glucose monitors (CGM) may improve glucose control. We assessed the feasibility and safety of CGM to target glucose control in preterm infants, to inform a randomised controlled trial (RCT). Design We performed a single centre study in very preterm infants during the first week of life. Accuracy was assessed by comparison of CGM with blood glucose levels (n=20 infants). In a separate pilot study of efficacy (n=20), real-time CGM combined with a paper guideline to target glucose control (2.6–10 mmol/L) was compared with standard neonatal care (masked CGM). Questionnaires were used to assess staff acceptability. Results No concerns were raised about infection or skin integrity at sensor site. The sensor performed well compared with point-of-care blood glucose measurements, mean bias of −0.27 (95% CI −0.35 to −0.19). Per cent time in target range (sensor glucose 2.6–10 mmol/L) was greater with CGM than POC (77% vs 59%, respectively) and per cent time sensor glucose >10 mmol/L was less with CGM than POC (24% vs 40%, respectively). The CGM also detected clinically unsuspected episodes of hypoglycaemia. Staff reported that the use of the CGM positively improved clinical care. Conclusions This study suggests that CGM has sufficient accuracy and utility in preterm infants to warrant formal testing in a RCT." @default.
- W2891979812 created "2018-09-27" @default.
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- W2891979812 date "2018-09-19" @default.
- W2891979812 modified "2023-09-27" @default.
- W2891979812 title "Targeting glucose control in preterm infants: pilot studies of continuous glucose monitoring" @default.
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- W2891979812 doi "https://doi.org/10.1136/archdischild-2018-314814" @default.
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