FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891982289> ?p ?o ?g. }

• W2891982289 endingPage "1563" @default.
• W2891982289 startingPage "1553" @default.
• W2891982289 abstract "We detail the development of a next-generation Streptococcus pneumoniae liposomal encapsulation of polysaccharides (LEPS) vaccine, with design characteristics geared toward best-in-class efficacy. The first generation LEPS vaccine, which contained 20 encapsulated pneumococcal capsular polysaccharides (CPSs) and two surface-displayed virulence-associated proteins (GlpO and PncO), enabling prophylactic potency against 70+ serotypes of Streptococcus pneumoniae (the causative agent of pneumococcal disease), was rationally redesigned for advanced clinical readiness and best-in-class coverage. In doing so, the virulent-specific GlpO protein antigen was removed from the final formulation due to off-target immunogenicity toward bacterial species within the human microbiome, while directed protection was maintained by increasing the dose of PncO from 17 to 68 μg. LEPS formulation parameters also readily facilitated an increase in CPS valency (to a total of 24) and systematic variation in protein-liposome attachment mechanisms in anticipation of clinical translation. An additional safety assessment study demonstrated that LEPS does not exhibit appreciable toxicological effects even when administered at ten times the effective dose. In summary, this new design offers the broadest, safest, and most-complete protection while maintaining desirable glycoconjugate-like features, positioning the LEPS vaccine platform for clinical success and a global health impact." @default.
• W2891982289 created "2018-09-27" @default.
• W2891982289 creator A5016688779 @default.
• W2891982289 creator A5016944193 @default.
• W2891982289 creator A5060438417 @default.
• W2891982289 creator A5088513533 @default.
• W2891982289 date "2018-09-04" @default.
• W2891982289 modified "2023-10-16" @default.
• W2891982289 title "Engineering a Next-Generation Glycoconjugate-Like <i>Streptococcus pneumoniae</i> Vaccine" @default.
• W2891982289 cites W1966863313 @default.
• W2891982289 cites W1975907958 @default.
• W2891982289 cites W1976667386 @default.
• W2891982289 cites W2005242840 @default.
• W2891982289 cites W2037083749 @default.
• W2891982289 cites W2037409969 @default.
• W2891982289 cites W2038507666 @default.
• W2891982289 cites W2045853263 @default.
• W2891982289 cites W2068383131 @default.
• W2891982289 cites W2071829962 @default.
• W2891982289 cites W2079081917 @default.
• W2891982289 cites W2083827952 @default.
• W2891982289 cites W2090499893 @default.
• W2891982289 cites W2105008621 @default.
• W2891982289 cites W2105680176 @default.
• W2891982289 cites W2111354542 @default.
• W2891982289 cites W2121263909 @default.
• W2891982289 cites W2121369371 @default.
• W2891982289 cites W2122017857 @default.
• W2891982289 cites W2123387973 @default.
• W2891982289 cites W2132596148 @default.
• W2891982289 cites W2141256847 @default.
• W2891982289 cites W2142127653 @default.
• W2891982289 cites W2147768434 @default.
• W2891982289 cites W2154857015 @default.
• W2891982289 cites W2164822179 @default.
• W2891982289 cites W2167500590 @default.
• W2891982289 cites W2169803204 @default.
• W2891982289 cites W2171096615 @default.
• W2891982289 cites W2292430240 @default.
• W2891982289 cites W2317658790 @default.
• W2891982289 cites W2413677169 @default.
• W2891982289 cites W2471285019 @default.
• W2891982289 cites W2546024328 @default.
• W2891982289 cites W2766920391 @default.
• W2891982289 doi "https://doi.org/10.1021/acsinfecdis.8b00100" @default.
• W2891982289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30180541" @default.
• W2891982289 hasPublicationYear "2018" @default.
• W2891982289 type Work @default.
• W2891982289 sameAs 2891982289 @default.
• W2891982289 citedByCount "16" @default.
• W2891982289 countsByYear W28919822892019 @default.
• W2891982289 countsByYear W28919822892020 @default.
• W2891982289 countsByYear W28919822892021 @default.
• W2891982289 countsByYear W28919822892022 @default.
• W2891982289 countsByYear W28919822892023 @default.
• W2891982289 crossrefType "journal-article" @default.
• W2891982289 hasAuthorship W2891982289A5016688779 @default.
• W2891982289 hasAuthorship W2891982289A5016944193 @default.
• W2891982289 hasAuthorship W2891982289A5060438417 @default.
• W2891982289 hasAuthorship W2891982289A5088513533 @default.
• W2891982289 hasBestOaLocation W28919822892 @default.
• W2891982289 hasConcept C104317684 @default.
• W2891982289 hasConcept C13426554 @default.
• W2891982289 hasConcept C147483822 @default.
• W2891982289 hasConcept C203014093 @default.
• W2891982289 hasConcept C2776152631 @default.
• W2891982289 hasConcept C2779301066 @default.
• W2891982289 hasConcept C2780868878 @default.
• W2891982289 hasConcept C2781253189 @default.
• W2891982289 hasConcept C501593827 @default.
• W2891982289 hasConcept C55493867 @default.
• W2891982289 hasConcept C60644358 @default.
• W2891982289 hasConcept C60987743 @default.
• W2891982289 hasConcept C71924100 @default.
• W2891982289 hasConcept C86803240 @default.
• W2891982289 hasConcept C89423630 @default.
• W2891982289 hasConceptScore W2891982289C104317684 @default.
• W2891982289 hasConceptScore W2891982289C13426554 @default.
• W2891982289 hasConceptScore W2891982289C147483822 @default.
• W2891982289 hasConceptScore W2891982289C203014093 @default.
• W2891982289 hasConceptScore W2891982289C2776152631 @default.
• W2891982289 hasConceptScore W2891982289C2779301066 @default.
• W2891982289 hasConceptScore W2891982289C2780868878 @default.
• W2891982289 hasConceptScore W2891982289C2781253189 @default.
• W2891982289 hasConceptScore W2891982289C501593827 @default.
• W2891982289 hasConceptScore W2891982289C55493867 @default.
• W2891982289 hasConceptScore W2891982289C60644358 @default.
• W2891982289 hasConceptScore W2891982289C60987743 @default.
• W2891982289 hasConceptScore W2891982289C71924100 @default.
• W2891982289 hasConceptScore W2891982289C86803240 @default.
• W2891982289 hasConceptScore W2891982289C89423630 @default.
• W2891982289 hasFunder F4320337355 @default.
• W2891982289 hasIssue "11" @default.
• W2891982289 hasLocation W28919822891 @default.
• W2891982289 hasLocation W28919822892 @default.
• W2891982289 hasLocation W28919822893 @default.
• W2891982289 hasOpenAccess W2891982289 @default.
• W2891982289 hasPrimaryLocation W28919822891 @default.

• next