FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891987403> ?p ?o ?g. }

• W2891987403 endingPage "3060" @default.
• W2891987403 startingPage "3051" @default.
• W2891987403 abstract "Chemotherapeutic drug targeting to lungs by way of microspheres after intravenous administration Sibghatullah Sangi,1 Nagaraja SreeHarsha,2 Abdulhakim Bawadekji,3 Mouhanad Al Ali4 1Department of Clinical Pharmacy, Faculty of Pharmacy, Northern Border University, Rafha, Saudi Arabia; 2Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia; 3Department of Biological Sciences, College of Science, Northern Border University, Arar, Saudi Arabia; 4Higher Institute of Health and Bio-products of Angers (ISSBA), Angers- France, Université d’Angers, Angers, France Purpose: Currently, microsphere technology plays a major role in the development of many new cancer therapies. In the current study, we proposed a targeted drug-delivery system to improve the treatment efficacy of one of the common conventional chemotherapeutic drugs used to treat lung tumors, 5-fluorouracil (5-FU).Materials and methods: Following the preparation and optimization of small, solid microspheres, ranging in diameter between 5 and 15 µm, the final product 5-fluorouracil gelatin (5-FUG) was formulated using a Buchi Nano Spray Dryer by varying the drug:polymer ratio.Results: Particle yield was calculated as 65% ± 1.2%, and the drug content in the formulation was recorded as 74% ± 1.6%. Particle surface morphology was examined as shriveled shape (crumpled/folded); particle size distribution displayed a binomial distribution, with a mean diameter of 9.6 µm. In vitro drug release studies revealed that ~36.4% of the 5-FU in 5-FUG was released in the first hour after injection. Clinically, this would lead to initial or burst release, facilitating a quick rise to therapeutic levels. In contrast to the pure 5-FU drug (89.2% of the drug released in the first 30 minutes), 99.1% of the drug in 5-FUG was released from the spray-dried particles for a period of 12 hours. A two-compartment model was used to generate plasma concentration–time curves. 5-FUG injection has a much different distribution in vivo in contrast to intravenous injection of 5-FU. In addition, the half-life after intravenous injection of 5-FUG, t1/2(α) = 1.23 hours and t1/2(β) = 18.3 hours, was considerably longer than that of 5-FU, t1/2(α) = 0.34 hours and t1/2(β) = 8.62 hours. Examination of stained lung tissue sections showed no histopathological tissue changes or evidence of gross pathology. In addition, the optimized formulation demonstrated an increased stability under both long-term and refrigerated storage conditions.Conclusion: Our goal was to develop similar delivery systems for other chemotherapeutic drugs that are site specific to different disease models/tumor types. Keywords: spray drying, 5-fluorouracil, cancer, microspheres, targeting" @default.
• W2891987403 created "2018-09-27" @default.
• W2891987403 creator A5006009964 @default.
• W2891987403 creator A5023795266 @default.
• W2891987403 creator A5040297048 @default.
• W2891987403 creator A5066558616 @default.
• W2891987403 date "2018-09-01" @default.
• W2891987403 modified "2023-09-30" @default.
• W2891987403 title "Chemotherapeutic drug targeting to lungs by way of microspheres after intravenous administration" @default.
• W2891987403 cites W1988909654 @default.
• W2891987403 cites W1996697333 @default.
• W2891987403 cites W1996725509 @default.
• W2891987403 cites W2000477211 @default.
• W2891987403 cites W2006161061 @default.
• W2891987403 cites W2014682822 @default.
• W2891987403 cites W2026079995 @default.
• W2891987403 cites W2040033900 @default.
• W2891987403 cites W2050772463 @default.
• W2891987403 cites W2051946179 @default.
• W2891987403 cites W2065263862 @default.
• W2891987403 cites W2089869880 @default.
• W2891987403 cites W2090826105 @default.
• W2891987403 cites W2123291552 @default.
• W2891987403 cites W2129689764 @default.
• W2891987403 cites W2131487381 @default.
• W2891987403 cites W2138331440 @default.
• W2891987403 cites W2148287035 @default.
• W2891987403 cites W2212044150 @default.
• W2891987403 cites W2235523093 @default.
• W2891987403 cites W2285693491 @default.
• W2891987403 cites W2316842585 @default.
• W2891987403 cites W2611606389 @default.
• W2891987403 doi "https://doi.org/10.2147/dddt.s173485" @default.
• W2891987403 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6151103" @default.
• W2891987403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30271120" @default.
• W2891987403 hasPublicationYear "2018" @default.
• W2891987403 type Work @default.
• W2891987403 sameAs 2891987403 @default.
• W2891987403 citedByCount "10" @default.
• W2891987403 countsByYear W28919874032021 @default.
• W2891987403 countsByYear W28919874032022 @default.
• W2891987403 countsByYear W28919874032023 @default.
• W2891987403 crossrefType "journal-article" @default.
• W2891987403 hasAuthorship W2891987403A5006009964 @default.
• W2891987403 hasAuthorship W2891987403A5023795266 @default.
• W2891987403 hasAuthorship W2891987403A5040297048 @default.
• W2891987403 hasAuthorship W2891987403A5066558616 @default.
• W2891987403 hasBestOaLocation W28919874031 @default.
• W2891987403 hasConcept C104863432 @default.
• W2891987403 hasConcept C127413603 @default.
• W2891987403 hasConcept C171250308 @default.
• W2891987403 hasConcept C189942447 @default.
• W2891987403 hasConcept C192562407 @default.
• W2891987403 hasConcept C2779820397 @default.
• W2891987403 hasConcept C2780035454 @default.
• W2891987403 hasConcept C42360764 @default.
• W2891987403 hasConcept C512399662 @default.
• W2891987403 hasConcept C71924100 @default.
• W2891987403 hasConcept C98274493 @default.
• W2891987403 hasConceptScore W2891987403C104863432 @default.
• W2891987403 hasConceptScore W2891987403C127413603 @default.
• W2891987403 hasConceptScore W2891987403C171250308 @default.
• W2891987403 hasConceptScore W2891987403C189942447 @default.
• W2891987403 hasConceptScore W2891987403C192562407 @default.
• W2891987403 hasConceptScore W2891987403C2779820397 @default.
• W2891987403 hasConceptScore W2891987403C2780035454 @default.
• W2891987403 hasConceptScore W2891987403C42360764 @default.
• W2891987403 hasConceptScore W2891987403C512399662 @default.
• W2891987403 hasConceptScore W2891987403C71924100 @default.
• W2891987403 hasConceptScore W2891987403C98274493 @default.
• W2891987403 hasLocation W28919874031 @default.
• W2891987403 hasLocation W28919874032 @default.
• W2891987403 hasLocation W28919874033 @default.
• W2891987403 hasLocation W28919874034 @default.
• W2891987403 hasLocation W28919874035 @default.
• W2891987403 hasOpenAccess W2891987403 @default.
• W2891987403 hasPrimaryLocation W28919874031 @default.
• W2891987403 hasRelatedWork W1558872876 @default.
• W2891987403 hasRelatedWork W1997309580 @default.
• W2891987403 hasRelatedWork W2187011375 @default.
• W2891987403 hasRelatedWork W2338412032 @default.
• W2891987403 hasRelatedWork W2735042559 @default.
• W2891987403 hasRelatedWork W2803175941 @default.
• W2891987403 hasRelatedWork W2961778046 @default.
• W2891987403 hasRelatedWork W3153475739 @default.
• W2891987403 hasRelatedWork W4287961260 @default.
• W2891987403 hasRelatedWork W2762853062 @default.
• W2891987403 hasVolume "Volume 12" @default.
• W2891987403 isParatext "false" @default.
• W2891987403 isRetracted "false" @default.
• W2891987403 magId "2891987403" @default.
• W2891987403 workType "article" @default.