FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891989645> ?p ?o ?g. }

• W2891989645 endingPage "1309" @default.
• W2891989645 startingPage "1295" @default.
• W2891989645 abstract "Matrine is a natural alkaloid isolated from the root and stem of the legume plant Sophora. Its anti-proliferative and pro-apoptotic effects on several types of cancer have been well-documented. However, the role of matrine in regulating mitochondrial homeostasis, particularly mitophagy in liver cancer apoptosis, remains uncertain. The aim of our study was to explore whether matrine promotes liver cancer cell apoptosis by modifying mitophagy. HepG2 cells were used in the study and treated with different doses of matrine. Cell viability and apoptosis were determined by MTT assay, TUNEL staining, western blotting, and LDH release assay. Mitophagy was monitored by immunofluorescence assay and western blotting. Mitochondrial function was assessed by immunofluorescence assay, ELISA, and western blotting. The results of our study indicated that matrine treatment dose-dependently reduced cell viability and increased the apoptotic rate of HepG2 cells. Functional studies demonstrated that matrine treatment induced mitochondrial dysfunction and activated mitochondrial apoptosis by inhibiting protective mitophagy. Re-activation of mitophagy abolished the pro-apoptotic effects of matrine on HepG2 cells. Molecular investigations further confirmed that matrine regulated mitophagy via the PINK1/Parkin pathways. Matrine blocked the PINK1/Parkin pathways and repressed mitophagy, whereas activation of the PINK1/Parkin pathways increased mitophagy activity and promoted HepG2 cell survival in the presence of matrine. Together, our data indicated that matrine promoted HepG2 cell apoptosis through a novel mechanism that acted via inhibiting mitophagy and the PINK1/Parkin pathways. This finding provides new insight into the molecular mechanism of matrine for treating liver cancer and offers a potential target to repress liver cancer progression by modulating mitophagy and the PINK1/Parkin pathways." @default.
• W2891989645 created "2018-09-27" @default.
• W2891989645 creator A5018795749 @default.
• W2891989645 creator A5038741949 @default.
• W2891989645 creator A5058249330 @default.
• W2891989645 date "2018-09-12" @default.
• W2891989645 modified "2023-10-18" @default.
• W2891989645 title "RETRACTED ARTICLE: Matrine promotes liver cancer cell apoptosis by inhibiting mitophagy and PINK1/Parkin pathways" @default.
• W2891989645 cites W2332664660 @default.
• W2891989645 cites W2528861718 @default.
• W2891989645 cites W2550652947 @default.
• W2891989645 cites W2556746616 @default.
• W2891989645 cites W2560665383 @default.
• W2891989645 cites W2560966368 @default.
• W2891989645 cites W2561808328 @default.
• W2891989645 cites W2566543319 @default.
• W2891989645 cites W2566717232 @default.
• W2891989645 cites W2568811756 @default.
• W2891989645 cites W2569191487 @default.
• W2891989645 cites W2577830243 @default.
• W2891989645 cites W2582663464 @default.
• W2891989645 cites W2582957437 @default.
• W2891989645 cites W2583414336 @default.
• W2891989645 cites W2585704327 @default.
• W2891989645 cites W2586141836 @default.
• W2891989645 cites W2586442417 @default.
• W2891989645 cites W2587319550 @default.
• W2891989645 cites W2588049838 @default.
• W2891989645 cites W2588933310 @default.
• W2891989645 cites W2591395115 @default.
• W2891989645 cites W2592018871 @default.
• W2891989645 cites W2593345096 @default.
• W2891989645 cites W2604300896 @default.
• W2891989645 cites W2605744063 @default.
• W2891989645 cites W2607216106 @default.
• W2891989645 cites W2607458295 @default.
• W2891989645 cites W2612061536 @default.
• W2891989645 cites W2725230559 @default.
• W2891989645 cites W2741271726 @default.
• W2891989645 cites W2747826704 @default.
• W2891989645 cites W2751220340 @default.
• W2891989645 cites W2751374171 @default.
• W2891989645 cites W2763698944 @default.
• W2891989645 cites W2768024671 @default.
• W2891989645 cites W2768365998 @default.
• W2891989645 cites W2769667901 @default.
• W2891989645 cites W2773489190 @default.
• W2891989645 cites W2775187110 @default.
• W2891989645 cites W2789331696 @default.
• W2891989645 cites W2789860518 @default.
• W2891989645 cites W2790553322 @default.
• W2891989645 cites W2791242967 @default.
• W2891989645 cites W2791560369 @default.
• W2891989645 cites W2791574216 @default.
• W2891989645 cites W2792941586 @default.
• W2891989645 cites W2793785635 @default.
• W2891989645 cites W2794268420 @default.
• W2891989645 cites W2794686887 @default.
• W2891989645 cites W2801343489 @default.
• W2891989645 cites W2802650264 @default.
• W2891989645 cites W2803011014 @default.
• W2891989645 cites W2884686428 @default.
• W2891989645 doi "https://doi.org/10.1007/s12192-018-0937-7" @default.
• W2891989645 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6237690" @default.
• W2891989645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30209783" @default.
• W2891989645 hasPublicationYear "2018" @default.
• W2891989645 type Work @default.
• W2891989645 sameAs 2891989645 @default.
• W2891989645 citedByCount "62" @default.
• W2891989645 countsByYear W28919896452019 @default.
• W2891989645 countsByYear W28919896452020 @default.
• W2891989645 countsByYear W28919896452021 @default.
• W2891989645 countsByYear W28919896452022 @default.
• W2891989645 countsByYear W28919896452023 @default.
• W2891989645 crossrefType "journal-article" @default.
• W2891989645 hasAuthorship W2891989645A5018795749 @default.
• W2891989645 hasAuthorship W2891989645A5038741949 @default.
• W2891989645 hasAuthorship W2891989645A5058249330 @default.
• W2891989645 hasBestOaLocation W28919896452 @default.
• W2891989645 hasConcept C142724271 @default.
• W2891989645 hasConcept C185592680 @default.
• W2891989645 hasConcept C190283241 @default.
• W2891989645 hasConcept C196795494 @default.
• W2891989645 hasConcept C203522944 @default.
• W2891989645 hasConcept C2776545273 @default.
• W2891989645 hasConcept C2776804853 @default.
• W2891989645 hasConcept C2777668072 @default.
• W2891989645 hasConcept C2779134260 @default.
• W2891989645 hasConcept C2779324830 @default.
• W2891989645 hasConcept C2779734285 @default.
• W2891989645 hasConcept C2780783641 @default.
• W2891989645 hasConcept C43617362 @default.
• W2891989645 hasConcept C53227056 @default.
• W2891989645 hasConcept C55493867 @default.
• W2891989645 hasConcept C71924100 @default.
• W2891989645 hasConcept C86803240 @default.
• W2891989645 hasConcept C95444343 @default.
• W2891989645 hasConcept C98274493 @default.

• next