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- W2891990135 abstract "The effectiveness of a simulated moving bed (SMB) technology in the continuous separation of fucose from a multi-component monosugar mixture, which stemmed from defatted microalgae, has recently been identified. To guarantee high economical efficiency of such fucose-production method, the comprehensive optimization of the relevant fucose-separation SMB process needs to be accomplished such that its production rate (Prate) and/or productivity (Prod) can be maximized while meeting the requirements on fucose product concentration (Cprod,F) and pressure drop (ΔPSMB). To resolve this issue, the SMB optimization program based on standing-wave-design method and genetic algorithm was prepared and then applied to the fucose-separation SMB optimization. It was found that the Prate, under a given particle size, could reach its maximum when the column length was selected to create a balance between the effects of the two limiting factors related to Cprod,F and ΔPSMB. It was also found that the Prate was governed by fucose yield, if the SMB would be in need of a relatively high Cprod,F; otherwise, the Prate was governed by feed flow rate. If the particle size of the SMB adsorbent was fixed at one of the commercially available ones, the SMB conditions leading to the highest Prate and the highest Prod coincided with each other. By contrast, if the particle size was included as one of optimization variables, the Prate and Prod represented a trade-off relationship. Finally, it was confirmed from the simultaneous optimization for Prate and Prod that the increase of particle size improved Prate at the cost of Prod, thereby causing the maximum Prod to be always attained at a smaller particle size than the maximum Prate regardless of the target Cprod,F level." @default.
- W2891990135 created "2018-09-27" @default.
- W2891990135 creator A5051565955 @default.
- W2891990135 date "2018-11-01" @default.
- W2891990135 modified "2023-09-24" @default.
- W2891990135 title "Optimization of production rate, productivity, and product concentration for a simulated moving bed process aimed atfucose separation using standing-wave-design and genetic algorithm" @default.
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- W2891990135 doi "https://doi.org/10.1016/j.chroma.2018.09.025" @default.
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