FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891990362> ?p ?o ?g. }

• W2891990362 endingPage "9" @default.
• W2891990362 startingPage "1" @default.
• W2891990362 abstract "Purpose . This study aimed to explore whether bone marrow- (BM-) derived endothelial progenitor cells (EPCs) contributing to monocrotaline- (MCT-) induced pulmonary arterial hypertension (PAH) in rats via modulating store-operated <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:msup><mml:mrow><mml:mi mathvariant=normal>C</mml:mi><mml:mi mathvariant=normal>a</mml:mi></mml:mrow><mml:mrow><mml:mn mathvariant=normal>2</mml:mn><mml:mo>+</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:math> channels (SOC). Methods . Sprague Dawley (SD) rats were assigned into MCT group (n = 30) and control group (n = 20). Rats in MCT group were subcutaneously administered with 60 mg/kg MCT solution, and rats in control group were injected with equal amount of vehicle. After 3 weeks of treatment, right ventricular systolic pressure (RVSP) and right ventricular hypertrophy index (RVHI) of two groups were measured, and BM-derived EPCs were isolated. Immunochemistry identification and vasculogenesis detection of EPCs were then performed. <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:msub><mml:mrow><mml:mfenced open=[ close=] separators=|><mml:mrow><mml:msup><mml:mrow><mml:mi mathvariant=normal>C</mml:mi><mml:mi mathvariant=normal>a</mml:mi></mml:mrow><mml:mrow><mml:mn mathvariant=normal>2</mml:mn><mml:mo>+</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:mfenced></mml:mrow><mml:mrow><mml:mi mathvariant=normal>c</mml:mi><mml:mi mathvariant=normal>y</mml:mi><mml:mi mathvariant=normal>t</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> measurement was performed to detect store-operated calcium entry (SOCE) in two groups, followed by determination of Orai and canonical transient receptor potential (TRPC) channels expression. Results . After 3 weeks of treatment, there were significant increases in RVSP and RVHI in MCT group compared with control group, indicating that MCT successfully induced PAH in rats. Moreover, the SOCE (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:msub><mml:mrow><mml:mfenced open=[ close=] separators=|><mml:mrow><mml:msup><mml:mrow><mml:mi mathvariant=normal>C</mml:mi><mml:mi mathvariant=normal>a</mml:mi></mml:mrow><mml:mrow><mml:mn mathvariant=normal>2</mml:mn><mml:mo>+</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:mfenced></mml:mrow><mml:mrow><mml:mi mathvariant=normal>c</mml:mi><mml:mi mathvariant=normal>y</mml:mi><mml:mi mathvariant=normal>t</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> rise) in BM-derived EPCs of MCT group was lower than that of control group. Furthermore, the expression levels of Orai3, TRPC1, TRPC3, and TRPC6 in BM-derived EPCs were decreased in MCT group in comparison with control group. Conclusions . The SOC activities were inhibited in BM-derived EPCs of MCT-treated rats. These results may be associated with the depressed expression of Orai3, TRPC1, TRPC3, and TRPC6, which are major mediators of SOC." @default.
• W2891990362 created "2018-09-27" @default.
• W2891990362 creator A5001431706 @default.
• W2891990362 creator A5010172596 @default.
• W2891990362 creator A5013038112 @default.
• W2891990362 creator A5022267524 @default.
• W2891990362 creator A5037677450 @default.
• W2891990362 creator A5056247736 @default.
• W2891990362 creator A5085352453 @default.
• W2891990362 creator A5090606755 @default.
• W2891990362 date "2018-09-18" @default.
• W2891990362 modified "2023-10-14" @default.
• W2891990362 title "Bone Marrow-Derived Endothelial Progenitor Cells Contribute to Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats via Inhibition of Store-Operated Ca2+ Channels" @default.
• W2891990362 cites W1970710439 @default.
• W2891990362 cites W1980819410 @default.
• W2891990362 cites W1986081870 @default.
• W2891990362 cites W2001859539 @default.
• W2891990362 cites W2002535975 @default.
• W2891990362 cites W2006343358 @default.
• W2891990362 cites W2017530043 @default.
• W2891990362 cites W2020703299 @default.
• W2891990362 cites W2034080004 @default.
• W2891990362 cites W2036145275 @default.
• W2891990362 cites W2040071771 @default.
• W2891990362 cites W205296583 @default.
• W2891990362 cites W2053704719 @default.
• W2891990362 cites W2059462860 @default.
• W2891990362 cites W2100577158 @default.
• W2891990362 cites W2101586949 @default.
• W2891990362 cites W2113370663 @default.
• W2891990362 cites W2127872440 @default.
• W2891990362 cites W2128450740 @default.
• W2891990362 cites W2134366751 @default.
• W2891990362 cites W2136978968 @default.
• W2891990362 cites W2140036290 @default.
• W2891990362 cites W2153224916 @default.
• W2891990362 cites W2157497165 @default.
• W2891990362 cites W2158255274 @default.
• W2891990362 cites W2161603584 @default.
• W2891990362 cites W2162095820 @default.
• W2891990362 cites W2165074913 @default.
• W2891990362 cites W2168881614 @default.
• W2891990362 cites W2334662631 @default.
• W2891990362 cites W2375598353 @default.
• W2891990362 cites W2469523769 @default.
• W2891990362 cites W2473222548 @default.
• W2891990362 cites W2487748251 @default.
• W2891990362 cites W2546945130 @default.
• W2891990362 cites W2626699816 @default.
• W2891990362 cites W2731206995 @default.
• W2891990362 cites W2745031427 @default.
• W2891990362 cites W2749236308 @default.
• W2891990362 cites W2749444476 @default.
• W2891990362 cites W2761072841 @default.
• W2891990362 cites W2766145666 @default.
• W2891990362 cites W2769941449 @default.
• W2891990362 cites W2792567835 @default.
• W2891990362 cites W2793174378 @default.
• W2891990362 doi "https://doi.org/10.1155/2018/4892349" @default.
• W2891990362 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6167576" @default.
• W2891990362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30320134" @default.
• W2891990362 hasPublicationYear "2018" @default.
• W2891990362 type Work @default.
• W2891990362 sameAs 2891990362 @default.
• W2891990362 citedByCount "4" @default.
• W2891990362 countsByYear W28919903622020 @default.
• W2891990362 countsByYear W28919903622022 @default.
• W2891990362 countsByYear W28919903622023 @default.
• W2891990362 crossrefType "journal-article" @default.
• W2891990362 hasAuthorship W2891990362A5001431706 @default.
• W2891990362 hasAuthorship W2891990362A5010172596 @default.
• W2891990362 hasAuthorship W2891990362A5013038112 @default.
• W2891990362 hasAuthorship W2891990362A5022267524 @default.
• W2891990362 hasAuthorship W2891990362A5037677450 @default.
• W2891990362 hasAuthorship W2891990362A5056247736 @default.
• W2891990362 hasAuthorship W2891990362A5085352453 @default.
• W2891990362 hasAuthorship W2891990362A5090606755 @default.
• W2891990362 hasBestOaLocation W28919903621 @default.
• W2891990362 hasConcept C11413529 @default.
• W2891990362 hasConcept C41008148 @default.
• W2891990362 hasConcept C71924100 @default.
• W2891990362 hasConceptScore W2891990362C11413529 @default.
• W2891990362 hasConceptScore W2891990362C41008148 @default.
• W2891990362 hasConceptScore W2891990362C71924100 @default.
• W2891990362 hasFunder F4320321001 @default.
• W2891990362 hasLocation W28919903621 @default.
• W2891990362 hasLocation W28919903622 @default.
• W2891990362 hasLocation W28919903623 @default.
• W2891990362 hasLocation W28919903624 @default.
• W2891990362 hasOpenAccess W2891990362 @default.
• W2891990362 hasPrimaryLocation W28919903621 @default.
• W2891990362 hasRelatedWork W1506200166 @default.
• W2891990362 hasRelatedWork W1995515455 @default.
• W2891990362 hasRelatedWork W2039318446 @default.
• W2891990362 hasRelatedWork W2048182022 @default.
• W2891990362 hasRelatedWork W2080531066 @default.
• W2891990362 hasRelatedWork W2604872355 @default.
• W2891990362 hasRelatedWork W2748952813 @default.

• next