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- W2891992136 abstract "Background: Polycystic ovary syndrome (PCOS)-induced oligomenorrhea can leave psychological and non-psychological impactson women. Among the proposed strategies for its treatment, herbal medications are of importance due to favorable effect profiles.Objectives: We planned a study to compare the effects of Celery and Anise combination (CAC) and metformin (met.) on oligomenorrheain PCOS patients.Methods:We conducted a triple-blind, Randomized clinical trial on 72 patients that were randomly allocated into two equal groupsto receive six capsules of either CAC (750mgeach) or met. (250mgeach) at three separate doses for 15 days beginning from the follicularphase. If the bleeding occurred, three capsules of either placebo or met. would be administered daily during the menstruationphase, and then the follicular phase step with six capsules would be repeated. If the bleeding did not occur, three capsules of eitherplacebo or met. would be administered each day for 15 days. The regularity of menstrual bleeding as the primary outcome, as wellas testosterone, luteinizing hormone/follicular stimulating hormone ratio (LH/FSH), and complications, was assessed before andafter the three cycles.Results: The mean agestandard deviation of patients was 26.56.1. The mean Body Mass Index was 26.43.5. CAC significantlyimproved oligomenorrhea (58.3% vs. 25%, P < 0.01), increased bleeding episodes (P = 0.003), and reduced testosterone (mean difference:0.16 vs. -0.02, P = 0.005) and LH/FSH (mean difference: 0.75 vs. -0.08, P = 0.002) without any major side effects compared tomet.Conclusions:We showed that Celery and Anise combination could regulate menstrual cycles and improve oligomenorrhea in polycysticovary syndrome patients superiorly to metformin." @default.
- W2891992136 created "2018-09-27" @default.
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- W2891992136 date "2018-09-08" @default.
- W2891992136 modified "2023-10-18" @default.
- W2891992136 title "Celery Plus Anise Versus Metformin for Treatment of Oligomenorrhea in Polycystic Ovary Syndrome: A Triple-Blind Randomized Clinical Trial" @default.
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- W2891992136 doi "https://doi.org/10.5812/ircmj.67181" @default.
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