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• W2891993145 abstract "Several groups have reported associations of primary biliary cholangitis with other autoimmune entities, particularly Sjögren's syndrome and hypothyroidism. Its prevalence and characteristics in Mexican patients is unknown. To determine the frequency and characteristics of autoimmune diseases in a Mexican cohort of patients with primary biliary cholangitis. The medical records of patients that presented with primary biliary cholangitis within the time frame of 2005 and 2012 were reviewed and assessed for other autoimmune diseases. Seventy-eight patients, 75 women and 3 men, were included. Their mean age was 55.8 years. Seventy-three cases had positive antimitochondrial antibodies (94.8%) and disease was confirmed in 5 through liver biopsy. Five patients (8%) had anti-smooth muscle antibodies and 55/78 (70.5%) had antinuclear antibodies by indirect immunofluorescence. Forty-nine patients (62.8%) were positive for an autoimmune disease other than primary biliary cholangitis. Among those, 20 patients had one associated disease, 14 had 2, and 15 patients had 3 concomitant diseases. They included: Sjögren's syndrome in 23/78 patients (29.5%), dysthyroidism in 21/78 cases (26.9%), Raynaud syndrome in 11/78 (14.1%), CREST syndrome in 9/78 patients (11.4%), rheumatoid arthritis in 6/78 patients (7.7%), vitiligo in 5/78 (6.4%), scleroderma in 4/78 patients (5.1%), and other diseases in 8 patients. In 12/78 patients (15.4%), there was a documented family background of autoimmune disease. The presence of autoimmune associations in our cohort was frequent, and similar in characteristics to the information reported by other groups. The clinical implications of those findings remain to be determined. La colangitis biliar primaria es una enfermedad hepática colestásica crónica de origen autoinmune. Diferentes grupos han reportado asociaciones de esta enfermedad con otros padecimientos autoinmunes, particularmente el síndrome de Sjögren y el hipotiroidismo. Se desconoce la prevalencia y las características en pacientes mexicanos. El objetivo del presente trabajo fue determinar la frecuencia y las características de padecimientos autoinmunes en una cohorte mexicana de pacientes con colangitis biliar primaria. Se realizó una revisión de los expedientes de pacientes con colangitis biliar primaria entre 2005 y 2012 evaluando por otras enfermedades autoinmunes. Se incluyeron 78 pacientes, 75 mujeres y 3 hombres, con una edad promedio de 55.8 años. Setenta y tres de ellos presentaron anticuerpos antimitocondriales positivos (94.8%) y 5 fueron confirmados mediante biopsia hepática. Cinco (8%) de los pacientes presentaron anticuerpos antimúsculo liso positivos y 55/78 (70.5%) presentaron anticuerpos antinucleares positivos por inmunofluorescencia indirecta. Cuarenta y nueve de los 78 (62.8%) pacientes presentaron otra enfermedad autoinmune además de la colangitis biliar primaria. De estos, 20 tuvieron solo una enfermedad asociada, 14 mostraron 2 enfermedades asociadas y 15, 3 enfermedades asociadas. Por orden de frecuencia descendente se encontraron: síndrome de Sjögren en 23/78 (29.5%) pacientes, distiroidismo en 21/78 (26.9%), fenómeno de Raynaud en 11/78 (14.1%), CREST en 9/78 (11.4%), artritis reumatoide en 6/78 (7.7%), vitiligo en 5/78 (6.4%), esclerodermia en 4/78 (5.1%) y otras en 8 pacientes. En 12/78 (15.4%) existió antecedente documentado de enfermedades autoinmunes en la familia. La presencia de asociaciones autoinmunes en nuestra cohorte fue frecuente y con características similares a lo reportado por otros grupos. Desconocemos las implicaciones clínicas de estos hallazgos." @default.
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• W2891993145 date "2019-04-01" @default.
• W2891993145 modified "2023-10-18" @default.
• W2891993145 title "Autoimmune associations in a Mexican cohort with primary biliary cholangitis" @default.
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• W2891993145 doi "https://doi.org/10.1016/j.rgmxen.2018.09.003" @default.
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