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- W2891994886 abstract "Introduction: Severe or refractory asthma is seen in approximately 5% of asthmatic subjects who have unsatisfactory symptom control despite adherence to high-dose inhaled glucocorticoid therapies resulting in significant morbidity, reduced quality of life and health-care cost implications. Asthma exhibits marked heterogeneity both clinically and at the molecular phenotypic level requiring specifically targeted treatments to block the key pathways of the disease. Monoclonal antibody-based biologics targeted at inhibition of the type 2 cytokines IL-4, IL-5, and IL-13 have considerable potential as effective treatments for severe asthma.Areas covered: This review is based on recent English-language original articles in PubMed or Medline that reported significant clinical findings on the current status, therapeutic potential, and safety of biologics targeted at IL-4, IL-5, and IL-13 in the treatment of asthma together with the potential utility of simple reproducible non-invasive biomarkers to guide the effective use of biologic-based therapy that do not require direct sampling of the airwaysExpert commentary: The further development of reproducible and straightforward discriminatory non-invasive biomarkers may aid identification of those patients most likely to benefit from treatment with these interventions." @default.
- W2891994886 created "2018-09-27" @default.
- W2891994886 creator A5024936437 @default.
- W2891994886 date "2018-09-17" @default.
- W2891994886 modified "2023-09-27" @default.
- W2891994886 title "Recent developments in the use of biologics targeting IL-5, IL-4, or IL-13 in severe refractory asthma" @default.
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- W2891994886 doi "https://doi.org/10.1080/17476348.2018.1520095" @default.
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