FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891998651> ?p ?o ?g. }

• W2891998651 abstract "Abstract Nucleotide-binding Oligomerization Domain-2 ( NOD2 ) mutations are associated with an increased risk to develop Crohn’s Disease. In previous studies, we have shown that Nod2−/− mice manifest increased proportion of Lamina Propria (LP) CD4+ LAP+ Foxp3− regulatory cells, when compared with Nod2 +/+ mice, while CD4+ Foxp3 + regulatory cells were not affected. Here, we investigated the Nod2 gut microbiota, by 16S rRNA pyrosequencing, at steady state and after TNBS-colitis induction in mice reared separately or in cohousing, correlating the microbial profiles with LP regulatory T cells proportion and tissue cytokines content. We found that enrichment of Rikenella and Alistipes ( Rikenellaceae ) in Nod2−/− mice at 8 weeks of age reared separately was associated with increased proportion of CD4+ LAP+ Foxp3− cells and less severe TNBS-colitis. In co-housed mice the acquisition of Rickenellaceae by Nod2 +/+ mice was associated with increased CD4+ LAP+ Foxp3− proportion and less severe colitis. Severe colitis was associated with enrichment of gram-negative pathobionts ( Escherichia and Enterococcus ), while less severe colitis with protective bacteria ( Barnesiella , Odoribacter and Clostridium IV ). Environmental factors acting on genetic background with different outcomes according to their impact on microbiota, predispose in different ways to inflammation. These results open a new scenario for therapeutic attempt to re-establish eubiosis in Inflammatory Bowel Disease patients with NOD2 polymorphisms." @default.
• W2891998651 created "2018-09-27" @default.
• W2891998651 creator A5006094365 @default.
• W2891998651 creator A5009414735 @default.
• W2891998651 creator A5023019523 @default.
• W2891998651 creator A5037070826 @default.
• W2891998651 creator A5056119983 @default.
• W2891998651 creator A5059998039 @default.
• W2891998651 creator A5070487148 @default.
• W2891998651 creator A5074404662 @default.
• W2891998651 creator A5077194201 @default.
• W2891998651 date "2018-09-24" @default.
• W2891998651 modified "2023-10-03" @default.
• W2891998651 title "Nod2 Deficiency in mice is Associated with Microbiota Variation Favouring the Expansion of mucosal CD4+ LAP+ Regulatory Cells" @default.
• W2891998651 cites W112634519 @default.
• W2891998651 cites W1642457845 @default.
• W2891998651 cites W1670573097 @default.
• W2891998651 cites W1981197190 @default.
• W2891998651 cites W1982061234 @default.
• W2891998651 cites W1996148181 @default.
• W2891998651 cites W2004192158 @default.
• W2891998651 cites W2021839438 @default.
• W2891998651 cites W2023300612 @default.
• W2891998651 cites W2037254336 @default.
• W2891998651 cites W2043667001 @default.
• W2891998651 cites W2061664992 @default.
• W2891998651 cites W2073731887 @default.
• W2891998651 cites W2097804771 @default.
• W2891998651 cites W2097875133 @default.
• W2891998651 cites W2100211989 @default.
• W2891998651 cites W2103108588 @default.
• W2891998651 cites W2105024397 @default.
• W2891998651 cites W2106618843 @default.
• W2891998651 cites W2107277218 @default.
• W2891998651 cites W2110300022 @default.
• W2891998651 cites W2110389012 @default.
• W2891998651 cites W2112320611 @default.
• W2891998651 cites W2120529603 @default.
• W2891998651 cites W2125932918 @default.
• W2891998651 cites W2132516980 @default.
• W2891998651 cites W2133856765 @default.
• W2891998651 cites W2135787796 @default.
• W2891998651 cites W2143777796 @default.
• W2891998651 cites W2145783127 @default.
• W2891998651 cites W2153791661 @default.
• W2891998651 cites W2159797569 @default.
• W2891998651 cites W2163911998 @default.
• W2891998651 cites W2164386968 @default.
• W2891998651 cites W2168247834 @default.
• W2891998651 cites W2169958991 @default.
• W2891998651 cites W2192080449 @default.
• W2891998651 cites W2230933569 @default.
• W2891998651 cites W2257287664 @default.
• W2891998651 cites W2316524210 @default.
• W2891998651 cites W2330359602 @default.
• W2891998651 cites W2370127743 @default.
• W2891998651 cites W2402932721 @default.
• W2891998651 cites W2417128146 @default.
• W2891998651 cites W2461193373 @default.
• W2891998651 cites W2465069238 @default.
• W2891998651 cites W2478983850 @default.
• W2891998651 cites W2506854111 @default.
• W2891998651 cites W2586856994 @default.
• W2891998651 cites W2591843498 @default.
• W2891998651 cites W2735859344 @default.
• W2891998651 cites W2744156497 @default.
• W2891998651 cites W2745006122 @default.
• W2891998651 cites W2765875974 @default.
• W2891998651 cites W2767134881 @default.
• W2891998651 cites W816410171 @default.
• W2891998651 doi "https://doi.org/10.1038/s41598-018-32583-z" @default.
• W2891998651 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6155205" @default.
• W2891998651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30250234" @default.
• W2891998651 hasPublicationYear "2018" @default.
• W2891998651 type Work @default.
• W2891998651 sameAs 2891998651 @default.
• W2891998651 citedByCount "23" @default.
• W2891998651 countsByYear W28919986512019 @default.
• W2891998651 countsByYear W28919986512020 @default.
• W2891998651 countsByYear W28919986512021 @default.
• W2891998651 countsByYear W28919986512022 @default.
• W2891998651 countsByYear W28919986512023 @default.
• W2891998651 crossrefType "journal-article" @default.
• W2891998651 hasAuthorship W2891998651A5006094365 @default.
• W2891998651 hasAuthorship W2891998651A5009414735 @default.
• W2891998651 hasAuthorship W2891998651A5023019523 @default.
• W2891998651 hasAuthorship W2891998651A5037070826 @default.
• W2891998651 hasAuthorship W2891998651A5056119983 @default.
• W2891998651 hasAuthorship W2891998651A5059998039 @default.
• W2891998651 hasAuthorship W2891998651A5070487148 @default.
• W2891998651 hasAuthorship W2891998651A5074404662 @default.
• W2891998651 hasAuthorship W2891998651A5077194201 @default.
• W2891998651 hasBestOaLocation W28919986511 @default.
• W2891998651 hasConcept C126322002 @default.
• W2891998651 hasConcept C136449434 @default.
• W2891998651 hasConcept C143121216 @default.
• W2891998651 hasConcept C17991360 @default.
• W2891998651 hasConcept C203014093 @default.
• W2891998651 hasConcept C2775862500 @default.
• W2891998651 hasConcept C2776914184 @default.

• next