Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891999307> ?p ?o ?g. }
- W2891999307 abstract "Abstract The molecular mechanisms underlying the metabolic shift toward increased glycolysis observed in pulmonary artery smooth muscle cells (PASMC) during the pathogenesis of pulmonary arterial hypertension (PAH) are not fully understood. Here we show that the glycolytic enzyme α-enolase (ENO1) regulates the metabolic reprogramming and malignant phenotype of PASMC. We show that ENO1 levels are elevated in patients with associated PAH and in animal models of hypoxic pulmonary hypertension (HPH). The silencing or inhibition of ENO1 decreases PASMC proliferation and de-differentiation, and induces PASMC apoptosis, whereas the overexpression of ENO1 promotes a synthetic, de- differentiated, and apoptotic-resistant phenotype via the AMPK-Akt pathway. The suppression of ENO1 prevents the hypoxia-induced metabolic shift from mitochondrial respiration to glycolysis in PASMC. Finally, we find that pharmacological inhibition of ENO1 reverses HPH in mice and rats, suggesting ENO1 as a regulator of pathogenic metabolic reprogramming in HPH." @default.
- W2891999307 created "2018-09-27" @default.
- W2891999307 creator A5000787907 @default.
- W2891999307 creator A5013671823 @default.
- W2891999307 creator A5026542961 @default.
- W2891999307 creator A5058336038 @default.
- W2891999307 creator A5073848642 @default.
- W2891999307 creator A5078424196 @default.
- W2891999307 date "2018-09-21" @default.
- W2891999307 modified "2023-10-16" @default.
- W2891999307 title "Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway" @default.
- W2891999307 cites W1515021808 @default.
- W2891999307 cites W1669342046 @default.
- W2891999307 cites W1775937474 @default.
- W2891999307 cites W1793883704 @default.
- W2891999307 cites W1964855107 @default.
- W2891999307 cites W1968894140 @default.
- W2891999307 cites W1969000984 @default.
- W2891999307 cites W1976555781 @default.
- W2891999307 cites W1982318323 @default.
- W2891999307 cites W1994255159 @default.
- W2891999307 cites W1998562191 @default.
- W2891999307 cites W1999388852 @default.
- W2891999307 cites W2018912420 @default.
- W2891999307 cites W2020993937 @default.
- W2891999307 cites W2022101765 @default.
- W2891999307 cites W2037679360 @default.
- W2891999307 cites W2038444072 @default.
- W2891999307 cites W2041507819 @default.
- W2891999307 cites W2042642849 @default.
- W2891999307 cites W2048893949 @default.
- W2891999307 cites W2057339327 @default.
- W2891999307 cites W2064255030 @default.
- W2891999307 cites W2068027702 @default.
- W2891999307 cites W2073737599 @default.
- W2891999307 cites W2090406819 @default.
- W2891999307 cites W2097259163 @default.
- W2891999307 cites W2102666037 @default.
- W2891999307 cites W2104743752 @default.
- W2891999307 cites W2113166898 @default.
- W2891999307 cites W2120945041 @default.
- W2891999307 cites W2132001965 @default.
- W2891999307 cites W2139960175 @default.
- W2891999307 cites W2142848427 @default.
- W2891999307 cites W2151293687 @default.
- W2891999307 cites W2152216118 @default.
- W2891999307 cites W2154508616 @default.
- W2891999307 cites W2156954477 @default.
- W2891999307 cites W2161681967 @default.
- W2891999307 cites W2163721144 @default.
- W2891999307 cites W2165928579 @default.
- W2891999307 cites W2167219679 @default.
- W2891999307 cites W2168503405 @default.
- W2891999307 cites W2223535266 @default.
- W2891999307 cites W2229340752 @default.
- W2891999307 cites W2253051214 @default.
- W2891999307 cites W2274562896 @default.
- W2891999307 cites W2508109728 @default.
- W2891999307 cites W2521282167 @default.
- W2891999307 cites W2530003115 @default.
- W2891999307 cites W2542093792 @default.
- W2891999307 cites W2548717227 @default.
- W2891999307 cites W2560116827 @default.
- W2891999307 cites W2569706514 @default.
- W2891999307 cites W2592714610 @default.
- W2891999307 cites W2597173714 @default.
- W2891999307 cites W2604253534 @default.
- W2891999307 cites W2614543793 @default.
- W2891999307 cites W2621496307 @default.
- W2891999307 cites W2728443108 @default.
- W2891999307 cites W2756466200 @default.
- W2891999307 cites W2758615270 @default.
- W2891999307 cites W2759764474 @default.
- W2891999307 cites W2766012717 @default.
- W2891999307 doi "https://doi.org/10.1038/s41467-018-06376-x" @default.
- W2891999307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6155017" @default.
- W2891999307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30242159" @default.
- W2891999307 hasPublicationYear "2018" @default.
- W2891999307 type Work @default.
- W2891999307 sameAs 2891999307 @default.
- W2891999307 citedByCount "81" @default.
- W2891999307 countsByYear W28919993072019 @default.
- W2891999307 countsByYear W28919993072020 @default.
- W2891999307 countsByYear W28919993072021 @default.
- W2891999307 countsByYear W28919993072022 @default.
- W2891999307 countsByYear W28919993072023 @default.
- W2891999307 crossrefType "journal-article" @default.
- W2891999307 hasAuthorship W2891999307A5000787907 @default.
- W2891999307 hasAuthorship W2891999307A5013671823 @default.
- W2891999307 hasAuthorship W2891999307A5026542961 @default.
- W2891999307 hasAuthorship W2891999307A5058336038 @default.
- W2891999307 hasAuthorship W2891999307A5073848642 @default.
- W2891999307 hasAuthorship W2891999307A5078424196 @default.
- W2891999307 hasBestOaLocation W28919993071 @default.
- W2891999307 hasConcept C104317684 @default.
- W2891999307 hasConcept C127716648 @default.
- W2891999307 hasConcept C134018914 @default.
- W2891999307 hasConcept C178790620 @default.
- W2891999307 hasConcept C184235292 @default.
- W2891999307 hasConcept C185592680 @default.