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- W2892003700 abstract "Low-birth-weight (LBW) piglets are at high risk for postnatal growth failure, mortality, and metabolic disorders later in life. Early-life microbial exposure is a potentially effective intervention strategy for modulating the health and metabolism of the host. Yet it has not been well elucidated whether the gut microbiota development in LBW piglets is different from their normal littermates, and its possible association with metabolite profiles. In the current study, 16S rRNA gene sequencing and metabolomics was used to investigate differences in the fecal microbiota and metabolites between LBW and normal piglets during early life, including day 3 (D3), 7 (D7), 14 (D14), 21 (D21, before weaning) and 35 (D35) after birth. Compared to their normal littermates, LBW piglets harbored lower proportions of Faecalibacterium on D3, Flavonifractor on D7, Lactobacillus, Streptococcus and Prevotella on D21, as well as Howardella on D21 and D35. However, the abundances of Campylobacter on D7 and D21, Prevotella on D14 and D35, Oscillibacter and Moryella on D14 and D21 and Bacteroides on D21 were significantly higher in LBW piglets than those in normal piglets. The results of the metabolomics analysis suggested that LBW significantly affected fecal metabolites involved in fatty acid metabolism (e.g., linoleic acid, α-linolenic acid and arachidonic acid), amino acid metabolism (e.g., valine, phenylalanine and glutamic acid), as well as bile acid biosynthesis (e.g., glycocholic acid, 25-hydroxycholesterol and chenodeoxycholic acid). Spearman correlation analysis revealed a significant negative association between Camplylobacter and N1-acetylspermine on D7, between Moryella and linoleic acid on D14, between Prevotella and chenodeoxycholic acid on D21, and between Howardella and phenylalanine on D35, respectively. Collectively, LBW piglets have a different gut bacterial community structure compared to NBW piglets during early life, especially from 7 to 21 days of age. Also, a distinctive metabolic status in LBW piglets might be partly associated with the altered intestinal microbiota. These findings may further elucidate factors potentially associated with the impaired growth and development of LBW piglets and facilitate the development of nutritional interventions." @default.
- W2892003700 created "2018-09-27" @default.
- W2892003700 creator A5001920959 @default.
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- W2892003700 creator A5080365301 @default.
- W2892003700 date "2018-09-07" @default.
- W2892003700 modified "2023-10-16" @default.
- W2892003700 title "Differences in the Gut Microbiota Establishment and Metabolome Characteristics Between Low- and Normal-Birth-Weight Piglets During Early-Life" @default.
- W2892003700 cites W1487806479 @default.
- W2892003700 cites W1588742782 @default.
- W2892003700 cites W166385293 @default.
- W2892003700 cites W1841906170 @default.
- W2892003700 cites W1926318014 @default.
- W2892003700 cites W1988077537 @default.
- W2892003700 cites W1989268575 @default.
- W2892003700 cites W1996889058 @default.
- W2892003700 cites W1997975781 @default.
- W2892003700 cites W2016073955 @default.
- W2892003700 cites W2024285987 @default.
- W2892003700 cites W2025552307 @default.
- W2892003700 cites W2027748672 @default.
- W2892003700 cites W2028012083 @default.
- W2892003700 cites W2029061313 @default.
- W2892003700 cites W2036734614 @default.
- W2892003700 cites W2042148396 @default.
- W2892003700 cites W2045938951 @default.
- W2892003700 cites W2049732163 @default.
- W2892003700 cites W2053422932 @default.
- W2892003700 cites W2071273298 @default.
- W2892003700 cites W2072970694 @default.
- W2892003700 cites W2074174777 @default.
- W2892003700 cites W2077307887 @default.
- W2892003700 cites W2079576804 @default.
- W2892003700 cites W2084404692 @default.
- W2892003700 cites W2084949910 @default.
- W2892003700 cites W2085971070 @default.
- W2892003700 cites W2087577664 @default.
- W2892003700 cites W2087765463 @default.
- W2892003700 cites W2088833470 @default.
- W2892003700 cites W2091922579 @default.
- W2892003700 cites W2093229186 @default.
- W2892003700 cites W2097136349 @default.
- W2892003700 cites W2099679330 @default.
- W2892003700 cites W2101004214 @default.
- W2892003700 cites W2105169496 @default.
- W2892003700 cites W2108718991 @default.
- W2892003700 cites W2117029130 @default.
- W2892003700 cites W2119178718 @default.
- W2892003700 cites W2120668531 @default.
- W2892003700 cites W2120760229 @default.
- W2892003700 cites W2122796622 @default.
- W2892003700 cites W2125784987 @default.
- W2892003700 cites W2125891960 @default.
- W2892003700 cites W2127349608 @default.
- W2892003700 cites W2128720274 @default.
- W2892003700 cites W2129532618 @default.
- W2892003700 cites W2132548846 @default.
- W2892003700 cites W2136879569 @default.
- W2892003700 cites W2143196592 @default.
- W2892003700 cites W2144363257 @default.
- W2892003700 cites W2144444795 @default.
- W2892003700 cites W2149756110 @default.
- W2892003700 cites W2150880737 @default.
- W2892003700 cites W2152276589 @default.
- W2892003700 cites W2155884253 @default.
- W2892003700 cites W2163224814 @default.
- W2892003700 cites W2165971615 @default.
- W2892003700 cites W2167530765 @default.
- W2892003700 cites W2170664134 @default.
- W2892003700 cites W2172020525 @default.
- W2892003700 cites W2239108612 @default.
- W2892003700 cites W2294145430 @default.
- W2892003700 cites W2328820760 @default.
- W2892003700 cites W2332679740 @default.
- W2892003700 cites W2398894736 @default.
- W2892003700 cites W2407328620 @default.
- W2892003700 cites W2416152044 @default.
- W2892003700 cites W2418959662 @default.
- W2892003700 cites W2532470957 @default.
- W2892003700 cites W2548516377 @default.
- W2892003700 cites W2551163639 @default.
- W2892003700 cites W2559088801 @default.
- W2892003700 cites W2588083737 @default.
- W2892003700 cites W2592617139 @default.
- W2892003700 cites W2603811597 @default.
- W2892003700 cites W2611223559 @default.
- W2892003700 cites W2627030505 @default.
- W2892003700 cites W2733888469 @default.
- W2892003700 cites W2738070183 @default.
- W2892003700 cites W2747668870 @default.
- W2892003700 cites W2765206455 @default.
- W2892003700 cites W2793072766 @default.
- W2892003700 cites W2803664483 @default.
- W2892003700 cites W770914721 @default.
- W2892003700 doi "https://doi.org/10.3389/fmicb.2018.01798" @default.