Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892006227> ?p ?o ?g. }
- W2892006227 endingPage "1414" @default.
- W2892006227 startingPage "1405" @default.
- W2892006227 abstract "Adenylosuccinate synthetase (AdSS) is an enzyme at regulatory point of purine metabolism. In pathogenic organisms which utilise only the purine salvage pathway, AdSS asserts itself as a promising drug target. One of these organisms is Helicobacter pylori, a wide-spread human pathogen involved in the development of many diseases. The rate of H. pylori antibiotic resistance is on the increase, making the quest for new drugs against this pathogen more important than ever. In this context, we describe here the properties of H. pylori AdSS. This enzyme exists in a dimeric active form independently of the presence of its ligands. Its narrow stability range and pH-neutral optimal working conditions reflect the bacterium’s high level of adaptation to its living environment. Efficient inhibition of H. pylori AdSS with hadacidin and adenylosuccinate gives hope of finding novel drugs that aim at eradicating this dangerous pathogen." @default.
- W2892006227 created "2018-09-27" @default.
- W2892006227 creator A5003941320 @default.
- W2892006227 creator A5012495163 @default.
- W2892006227 creator A5020210972 @default.
- W2892006227 creator A5029236447 @default.
- W2892006227 creator A5032820583 @default.
- W2892006227 creator A5060153518 @default.
- W2892006227 creator A5070469112 @default.
- W2892006227 creator A5089245279 @default.
- W2892006227 date "2018-01-01" @default.
- W2892006227 modified "2023-10-10" @default.
- W2892006227 title "In the quest for new targets for pathogen eradication: the adenylosuccinate synthetase from the bacterium<i>Helicobacter pylori</i>" @default.
- W2892006227 cites W12984822 @default.
- W2892006227 cites W1549043871 @default.
- W2892006227 cites W1600838929 @default.
- W2892006227 cites W1606872479 @default.
- W2892006227 cites W1673841581 @default.
- W2892006227 cites W1965457417 @default.
- W2892006227 cites W1970959709 @default.
- W2892006227 cites W1972131774 @default.
- W2892006227 cites W1972580507 @default.
- W2892006227 cites W1973507832 @default.
- W2892006227 cites W1975317507 @default.
- W2892006227 cites W1980901364 @default.
- W2892006227 cites W1992710524 @default.
- W2892006227 cites W1996297925 @default.
- W2892006227 cites W2024361927 @default.
- W2892006227 cites W2036330755 @default.
- W2892006227 cites W2045860444 @default.
- W2892006227 cites W2047437491 @default.
- W2892006227 cites W2062662267 @default.
- W2892006227 cites W2065687475 @default.
- W2892006227 cites W2066192536 @default.
- W2892006227 cites W2070485128 @default.
- W2892006227 cites W2076840863 @default.
- W2892006227 cites W2082794895 @default.
- W2892006227 cites W2093491670 @default.
- W2892006227 cites W2105424869 @default.
- W2892006227 cites W2110132014 @default.
- W2892006227 cites W2124089608 @default.
- W2892006227 cites W2127322768 @default.
- W2892006227 cites W2127781435 @default.
- W2892006227 cites W2128635872 @default.
- W2892006227 cites W2139065251 @default.
- W2892006227 cites W2143107875 @default.
- W2892006227 cites W2199203801 @default.
- W2892006227 cites W2397599314 @default.
- W2892006227 cites W2435770003 @default.
- W2892006227 cites W2602609233 @default.
- W2892006227 cites W2603672279 @default.
- W2892006227 cites W2608178048 @default.
- W2892006227 cites W2770464558 @default.
- W2892006227 cites W2787063176 @default.
- W2892006227 cites W2793923874 @default.
- W2892006227 cites W4236377851 @default.
- W2892006227 cites W4244736178 @default.
- W2892006227 cites W4293247451 @default.
- W2892006227 cites W65766253 @default.
- W2892006227 cites W139531753 @default.
- W2892006227 doi "https://doi.org/10.1080/14756366.2018.1506773" @default.
- W2892006227 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6136348" @default.
- W2892006227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30191734" @default.
- W2892006227 hasPublicationYear "2018" @default.
- W2892006227 type Work @default.
- W2892006227 sameAs 2892006227 @default.
- W2892006227 citedByCount "8" @default.
- W2892006227 countsByYear W28920062272019 @default.
- W2892006227 countsByYear W28920062272020 @default.
- W2892006227 countsByYear W28920062272021 @default.
- W2892006227 countsByYear W28920062272022 @default.
- W2892006227 countsByYear W28920062272023 @default.
- W2892006227 crossrefType "journal-article" @default.
- W2892006227 hasAuthorship W2892006227A5003941320 @default.
- W2892006227 hasAuthorship W2892006227A5012495163 @default.
- W2892006227 hasAuthorship W2892006227A5020210972 @default.
- W2892006227 hasAuthorship W2892006227A5029236447 @default.
- W2892006227 hasAuthorship W2892006227A5032820583 @default.
- W2892006227 hasAuthorship W2892006227A5060153518 @default.
- W2892006227 hasAuthorship W2892006227A5070469112 @default.
- W2892006227 hasAuthorship W2892006227A5089245279 @default.
- W2892006227 hasBestOaLocation W28920062271 @default.
- W2892006227 hasConcept C151730666 @default.
- W2892006227 hasConcept C181199279 @default.
- W2892006227 hasConcept C24527192 @default.
- W2892006227 hasConcept C2776409635 @default.
- W2892006227 hasConcept C2776460866 @default.
- W2892006227 hasConcept C2776476023 @default.
- W2892006227 hasConcept C2779343474 @default.
- W2892006227 hasConcept C523546767 @default.
- W2892006227 hasConcept C54355233 @default.
- W2892006227 hasConcept C55493867 @default.
- W2892006227 hasConcept C86803240 @default.
- W2892006227 hasConcept C89423630 @default.
- W2892006227 hasConceptScore W2892006227C151730666 @default.
- W2892006227 hasConceptScore W2892006227C181199279 @default.
- W2892006227 hasConceptScore W2892006227C24527192 @default.
- W2892006227 hasConceptScore W2892006227C2776409635 @default.