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• W2892007026 abstract "Abstract Biological activity can depend strongly on stereoisomerism and enantiomeric states because ligand-binding motifs and the interfaces of protein–protein and protein–biomolecule interactions typically involve chiral centres. For instance, R-thalidomide is used to treat nausea, but S-thalidomide can cause birth defects. Given that more than 50% of newly developed pharmaceuticals have chiral centres, the analysis of the enantiopurity of small molecules is crucial in drug development. However, conventional methods for chiral analysis, including high-performance liquid chromatography, can be limited by relatively time-consuming sample preparation and analysis times (up to ~ 1 h). In this context, use of ion-mobility spectrometry-mass spectrometry (IMS-MS) has shown to be promising for rapid, analytical chiral separations. Here, we review the use of IMS-MS for chiral analysis, which has the advantage that chiral molecules can be separated on a millisecond timescale for sensitive detection by MS." @default.
• W2892007026 created "2018-09-27" @default.
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• W2892007026 date "2019-01-01" @default.
• W2892007026 modified "2023-10-16" @default.
• W2892007026 title "Ion-Mobility Mass Spectrometry for Chiral Analysis of Small Molecules" @default.
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• W2892007026 doi "https://doi.org/10.1016/bs.coac.2018.08.009" @default.
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