FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892007455> ?p ?o ?g. }

• W2892007455 endingPage "308" @default.
• W2892007455 startingPage "289" @default.
• W2892007455 abstract "Because proteasomes catalyze most of the protein degradation in mammalian cells, and their functioning is essential for cellular homeostasis, proteasome structure, biochemical mechanisms, and regulation in normal and disease states are now widely studied and are of major importance. In addition, inhibitors of the proteasome’s peptidase activity have proven to be very valuable as research tools and in the treatment of hematologic malignancies, and a number of newer pharmacological agents that alter proteasome function are being developed. The rapid degradation of ubiquitinated proteins by the 26S proteasome involves multiple enzymatic and non-enzymatic steps, including the binding of ubiquitinated substrates to the 19S particle (Subheading 3.2), opening the gated substrate entry channel into the 20S particle (Subheading 3.3), disassembly of the Ub chain (Subheading 3.4), ATP hydrolysis (Subheading 3.5), substrate unfolding and translocation, and proteolysis within the 20S particle (Subheadings 3.3 and 3.7). Assaying each of these processes is important if we are to fully understand the physiological regulation of proteasome function and the effects of disease or drugs. Here, we describe several methods that we have found useful to measure many of these individual activities using purified proteasomes. Studies using these approaches have already provided valuable new insights into the effects of post-synthetic modifications to 26S subunits, the physiological regulation of the ubiquitin-proteasome system, and the impairment of proteasome activity in neurodegenerative disease. These advances would not have been possible if only the standard assays of peptidase activity were used." @default.
• W2892007455 created "2018-09-27" @default.
• W2892007455 creator A5006962945 @default.
• W2892007455 creator A5017903974 @default.
• W2892007455 creator A5029236300 @default.
• W2892007455 date "2018-01-01" @default.
• W2892007455 modified "2023-09-30" @default.
• W2892007455 title "Measurement of the Multiple Activities of 26S Proteasomes" @default.
• W2892007455 cites W1496897161 @default.
• W2892007455 cites W1516878062 @default.
• W2892007455 cites W1525435128 @default.
• W2892007455 cites W1548321971 @default.
• W2892007455 cites W1556426431 @default.
• W2892007455 cites W1856873384 @default.
• W2892007455 cites W1971841367 @default.
• W2892007455 cites W1981324044 @default.
• W2892007455 cites W1988100248 @default.
• W2892007455 cites W1997710361 @default.
• W2892007455 cites W1997827461 @default.
• W2892007455 cites W1999188297 @default.
• W2892007455 cites W2000596494 @default.
• W2892007455 cites W2001234769 @default.
• W2892007455 cites W2006975754 @default.
• W2892007455 cites W2012296420 @default.
• W2892007455 cites W2014630160 @default.
• W2892007455 cites W2017033636 @default.
• W2892007455 cites W2022703044 @default.
• W2892007455 cites W2026463310 @default.
• W2892007455 cites W2036380827 @default.
• W2892007455 cites W2048450765 @default.
• W2892007455 cites W2048737347 @default.
• W2892007455 cites W2049743082 @default.
• W2892007455 cites W2052302154 @default.
• W2892007455 cites W2060354742 @default.
• W2892007455 cites W2068134926 @default.
• W2892007455 cites W2068696470 @default.
• W2892007455 cites W2072818588 @default.
• W2892007455 cites W2079231931 @default.
• W2892007455 cites W2080075851 @default.
• W2892007455 cites W2081744774 @default.
• W2892007455 cites W2097164847 @default.
• W2892007455 cites W2106906885 @default.
• W2892007455 cites W2118643900 @default.
• W2892007455 cites W2130119946 @default.
• W2892007455 cites W2136583861 @default.
• W2892007455 cites W2142316927 @default.
• W2892007455 cites W2157193371 @default.
• W2892007455 cites W2159823053 @default.
• W2892007455 cites W2162223351 @default.
• W2892007455 cites W2195466096 @default.
• W2892007455 cites W2203610959 @default.
• W2892007455 cites W2277539891 @default.
• W2892007455 cites W2340572980 @default.
• W2892007455 cites W2421054514 @default.
• W2892007455 cites W2588396652 @default.
• W2892007455 cites W2592937673 @default.
• W2892007455 cites W2606581283 @default.
• W2892007455 cites W2606744545 @default.
• W2892007455 cites W2615829409 @default.
• W2892007455 cites W2767075954 @default.
• W2892007455 doi "https://doi.org/10.1007/978-1-4939-8706-1_19" @default.
• W2892007455 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6441976" @default.
• W2892007455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30242717" @default.
• W2892007455 hasPublicationYear "2018" @default.
• W2892007455 type Work @default.
• W2892007455 sameAs 2892007455 @default.
• W2892007455 citedByCount "7" @default.
• W2892007455 countsByYear W28920074552019 @default.
• W2892007455 countsByYear W28920074552020 @default.
• W2892007455 countsByYear W28920074552021 @default.
• W2892007455 countsByYear W28920074552022 @default.
• W2892007455 countsByYear W28920074552023 @default.
• W2892007455 crossrefType "book-chapter" @default.
• W2892007455 hasAuthorship W2892007455A5006962945 @default.
• W2892007455 hasAuthorship W2892007455A5017903974 @default.
• W2892007455 hasAuthorship W2892007455A5029236300 @default.
• W2892007455 hasBestOaLocation W28920074552 @default.
• W2892007455 hasConcept C104317684 @default.
• W2892007455 hasConcept C14036430 @default.
• W2892007455 hasConcept C181199279 @default.
• W2892007455 hasConcept C185592680 @default.
• W2892007455 hasConcept C25602115 @default.
• W2892007455 hasConcept C27740335 @default.
• W2892007455 hasConcept C2781307694 @default.
• W2892007455 hasConcept C2992195973 @default.
• W2892007455 hasConcept C55493867 @default.
• W2892007455 hasConcept C70721500 @default.
• W2892007455 hasConcept C86803240 @default.
• W2892007455 hasConcept C95444343 @default.
• W2892007455 hasConceptScore W2892007455C104317684 @default.
• W2892007455 hasConceptScore W2892007455C14036430 @default.
• W2892007455 hasConceptScore W2892007455C181199279 @default.
• W2892007455 hasConceptScore W2892007455C185592680 @default.
• W2892007455 hasConceptScore W2892007455C25602115 @default.
• W2892007455 hasConceptScore W2892007455C27740335 @default.
• W2892007455 hasConceptScore W2892007455C2781307694 @default.
• W2892007455 hasConceptScore W2892007455C2992195973 @default.
• W2892007455 hasConceptScore W2892007455C55493867 @default.

• next