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• W2892010503 abstract "The zona pellucida (ZP) surrounding human embryo breaks out at the blastocyst stage to start the deployment process. It is known the ZP hardens during vitrification and embryos can become trapped or hatching may be difficult after thawing. The artificial rupture of the ZP named as assisted hatching (AH) has been used in attempts to improve the chances of implantation in frozen-thawed embryo transfer cycles. We hypothesized that taking off higher amount of ZP, about 25% (quarter-laser-AH), in frozen-thawed blastocysts allow faster and complete hatching compared to regular-laser-AH, in which just a small piece of ZP is took off. This strategy could improve clinical outcomes. The aim of this study was to evaluate clinical outcomes of frozen-thawed blastocysts submitted to quarter-laser AH compared to regular-laser AH to opening ZP before transfer. Retrospective cohort of frozen-thawed embryo transfers cycles performed during 2017 in a private reproductive medicine center. This study reviewed 316 frozen-thawed embryos transfers. Cycles with cleavage embryos transfers and preimplantacional genetic screening were excluded and 193 cycles with frozen-thawed blastocyst transfers were analyzed. Cycles were split into two groups according to AH: 78 cycles had regular-laser-AH and 115 had quarter-laser-AH. AH was performed on day 5 by using laser (Octax Eyeware, Germany), 1.8 ms, directed to the proper region of ZP where inner cell mass were not adjacent to the inner membrane. In regular-AH the ZP was punctured by 2-3 shoots and produced a small opening. In quarter-laser-AH a quarter of ZP was taken off by 5-6 shoots. Patients age (37.4±4.9 versus 37.5±4.8, p=0.993) were similar in regular-laser-AH and quarter-laser-AH groups, respectively. A mean of two frozen-thawed blastocysts were transferred per patient (1.8±0.5 versus 1.9±0.6, p=0.299, respectively) and a top quality blastocysts was transferred when available in 56.0% of cycles in regular-laser-AH and 66.1% of quarter-laser-AH groups (p=0.162). The biochemical pregnancy (56.4% versus 57.4%, p=0.505), clinical pregnancy (43.6% versus 42.6%, p=0.505) and live birth rates (37.2% versus 37.5%, p=0.523) were equivalent between regular-laser-AH and quarter-laser-AH groups, respectively. Despite of hypothesis that quarter-laser-AH could improve clinical outcomes due to ZP hardening in frozen-thawed blastocysts transfers, we demonstrated similar results compared to regular-laser-AH. The outcomes should be interpreted with caution as the number of cycles included in this study is relatively small and the retrospective design are limitations of this study. Nonetheless, we may suggest that once AH is performed, the size of opening is not determinant of clinical outcomes in frozen-thawed blastocysts transfers." @default.
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• W2892010503 date "2018-09-01" @default.
• W2892010503 modified "2023-09-26" @default.
• W2892010503 title "Efficacy of quarter-laser zona pellucida assisted hatching in frozen-thawed blastocyst transfers" @default.
• W2892010503 doi "https://doi.org/10.1016/j.fertnstert.2018.07.627" @default.
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