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- W2892012523 abstract "Locomotor behaviors are critical for survival and enable animals to navigate their environment, find food and evade predators. The circuits in the brain and spinal cord that initiate and maintain such different modes of locomotion in vertebrates have been studied in numerous species for over a century. In recent decades, the zebrafish has emerged as one of the main model systems for the study of locomotion, owing to its experimental amenability, and work in zebrafish has revealed numerous new insights into locomotor circuit function. Here, we review the literature that has led to our current understanding of the neural circuits controlling swimming and escape in zebrafish. We highlight recent studies that have enriched our comprehension of key topics, such as the interactions between premotor excitatory interneurons (INs) and motoneurons (MNs), supraspinal and spinal circuits that coordinate escape maneuvers, and developmental changes in overall circuit composition. We also discuss roles for neuromodulators and sensory inputs in modifying the relative strengths of constituent circuit components to provide flexibility in zebrafish behavior, allowing the animal to accommodate changes in the environment. We aim to provide a coherent framework for understanding the circuitry in the brain and spinal cord of zebrafish that allows the animal to flexibly transition between different speeds, and modes, of locomotion." @default.
- W2892012523 created "2018-09-27" @default.
- W2892012523 creator A5041125818 @default.
- W2892012523 creator A5052543527 @default.
- W2892012523 creator A5070797610 @default.
- W2892012523 creator A5083433721 @default.
- W2892012523 creator A5088825287 @default.
- W2892012523 date "2018-09-13" @default.
- W2892012523 modified "2023-10-17" @default.
- W2892012523 title "Principles Governing Locomotion in Vertebrates: Lessons From Zebrafish" @default.
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