FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892012697> ?p ?o ?g. }

• W2892012697 endingPage "377" @default.
• W2892012697 startingPage "354" @default.
• W2892012697 abstract "Sequential adaptive clinical trials allow for early termination of drug testing at interim analysis points if the evidence suggests that the candidate drug or therapy is effective (stopping for benefit) or that the drug will not demonstrate to be better than existing therapies (stopping for futility). Early stopping allows the trial sponsor to mitigate investment risks on ineffective drugs and to shorten the development timeline of effective drugs, thus reducing costs and expediting patients’ access to these new therapies. However, this new flexibility may translate into a higher risk of deriving incorrect conclusions from the trial in the form of false positives or false negatives. The authors examine the causes and implications of wrongly terminating the development of an effective drug, which may lead to unrecoverable expenses and unfulfilled patient needs. The authors find that the risk of deriving incorrect conclusions from the trial increases with the number of interim analyses performed throughout its course. The insight for management: Contrary to the literature’s focus on false positives, false negatives can be more likely; thus, whenever the drug’s characteristics and the targeted disease permit, aggressive trial designs should be chosen over conservative ones to detect small but beneficial treatment differences." @default.
• W2892012697 created "2018-09-27" @default.
• W2892012697 creator A5006720676 @default.
• W2892012697 creator A5062910371 @default.
• W2892012697 date "2018-09-01" @default.
• W2892012697 modified "2023-09-27" @default.
• W2892012697 title "Trial Termination and Drug Misclassification in Sequential Adaptive Clinical Trials" @default.
• W2892012697 cites W1511011310 @default.
• W2892012697 cites W1599846307 @default.
• W2892012697 cites W1971330057 @default.
• W2892012697 cites W1974618278 @default.
• W2892012697 cites W1979533557 @default.
• W2892012697 cites W1984488298 @default.
• W2892012697 cites W1986307948 @default.
• W2892012697 cites W1992162322 @default.
• W2892012697 cites W1997863459 @default.
• W2892012697 cites W2001203833 @default.
• W2892012697 cites W2005494948 @default.
• W2892012697 cites W2017325052 @default.
• W2892012697 cites W2021548187 @default.
• W2892012697 cites W2024484688 @default.
• W2892012697 cites W2027728949 @default.
• W2892012697 cites W2029149156 @default.
• W2892012697 cites W2032770552 @default.
• W2892012697 cites W2041214084 @default.
• W2892012697 cites W2042803707 @default.
• W2892012697 cites W2044390029 @default.
• W2892012697 cites W2048448179 @default.
• W2892012697 cites W2053830943 @default.
• W2892012697 cites W2054213156 @default.
• W2892012697 cites W2059707463 @default.
• W2892012697 cites W2061859918 @default.
• W2892012697 cites W2079843690 @default.
• W2892012697 cites W2086123233 @default.
• W2892012697 cites W2088461543 @default.
• W2892012697 cites W2091861078 @default.
• W2892012697 cites W2100439608 @default.
• W2892012697 cites W2101881391 @default.
• W2892012697 cites W2106919063 @default.
• W2892012697 cites W2113417517 @default.
• W2892012697 cites W2119184505 @default.
• W2892012697 cites W2127151679 @default.
• W2892012697 cites W2127772814 @default.
• W2892012697 cites W2135570662 @default.
• W2892012697 cites W2154950075 @default.
• W2892012697 cites W2155924336 @default.
• W2892012697 cites W2161095279 @default.
• W2892012697 cites W2163724055 @default.
• W2892012697 cites W2165357065 @default.
• W2892012697 cites W2166550586 @default.
• W2892012697 cites W2273267066 @default.
• W2892012697 cites W2324869316 @default.
• W2892012697 cites W2325921774 @default.
• W2892012697 cites W2493712194 @default.
• W2892012697 cites W2570006193 @default.
• W2892012697 cites W2587424870 @default.
• W2892012697 cites W2747159355 @default.
• W2892012697 cites W4211205251 @default.
• W2892012697 cites W4242589154 @default.
• W2892012697 cites W4293775420 @default.
• W2892012697 cites W776995397 @default.
• W2892012697 doi "https://doi.org/10.1287/serv.2018.0217" @default.
• W2892012697 hasPublicationYear "2018" @default.
• W2892012697 type Work @default.
• W2892012697 sameAs 2892012697 @default.
• W2892012697 citedByCount "6" @default.
• W2892012697 countsByYear W28920126972018 @default.
• W2892012697 countsByYear W28920126972019 @default.
• W2892012697 countsByYear W28920126972020 @default.
• W2892012697 countsByYear W28920126972022 @default.
• W2892012697 crossrefType "journal-article" @default.
• W2892012697 hasAuthorship W2892012697A5006720676 @default.
• W2892012697 hasAuthorship W2892012697A5062910371 @default.
• W2892012697 hasConcept C105795698 @default.
• W2892012697 hasConcept C112930515 @default.
• W2892012697 hasConcept C126322002 @default.
• W2892012697 hasConcept C127413603 @default.
• W2892012697 hasConcept C134448949 @default.
• W2892012697 hasConcept C154945302 @default.
• W2892012697 hasConcept C166957645 @default.
• W2892012697 hasConcept C177713679 @default.
• W2892012697 hasConcept C201995342 @default.
• W2892012697 hasConcept C2776957806 @default.
• W2892012697 hasConcept C2780035454 @default.
• W2892012697 hasConcept C2780598303 @default.
• W2892012697 hasConcept C33923547 @default.
• W2892012697 hasConcept C41008148 @default.
• W2892012697 hasConcept C535046627 @default.
• W2892012697 hasConcept C61943457 @default.
• W2892012697 hasConcept C64869954 @default.
• W2892012697 hasConcept C71924100 @default.
• W2892012697 hasConcept C95457728 @default.
• W2892012697 hasConcept C98274493 @default.
• W2892012697 hasConceptScore W2892012697C105795698 @default.
• W2892012697 hasConceptScore W2892012697C112930515 @default.
• W2892012697 hasConceptScore W2892012697C126322002 @default.
• W2892012697 hasConceptScore W2892012697C127413603 @default.
• W2892012697 hasConceptScore W2892012697C134448949 @default.

• next