FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892016893> ?p ?o ?g. }

• W2892016893 abstract "Increasing evidence indicates that long non-coding RNAs (lncRNAs) are closely associated with the progression of human cancer, including colorectal cancer (CRC). A previous study suggested that lncRNA LINC01503 promotes squamous cell carcinoma progression. However, the function of LINC01503 in CRC has remained elusive. The present study indicated that LINC01503 was significantly upregulated in CRC tissues compared with that in adjacent normal tissues as detected by reverse transcription‑quantitative polymerase chain reaction. It was demonstrated that knockdown of long intergenic non‑protein coding RNA (LINC)01503 markedly inhibited the proliferation and invasion of CRC cells, whereas overexpression of LINC01503 had the opposite effects, as indicated by Cell Counting kit‑8 and Transwell assays. Mechanistically, it was revealed that LINC01503 serves as a sponge for microRNA (miR)‑4492, which targets forkhead box K1 (FOXK1) in CRC cells. In addition, luciferase reporter assays demonstrated the direct binding of miR‑4492 mimics to LINC01503 and to a sequence in the 3'‑untranslated region of FOXK1. Furthermore, it was demonstrated that overexpression of LINC01503 reduced the availability of miR‑4492 in CRC cells. Furthermore, miR‑4492 mimics inhibited FOXK1 expression, while simultaneous overexpression of LINC01503 abolished this effect. Finally, it was demonstrated that restoration of FOXK1 abolished the inhibitory effect of LINC01503 knockdown on CRC cell proliferation and invasion. Taken together, the present results suggested that LINC01503 promotes CRC progression via acting as a competing endogenous RNA for miR‑4492/FOXK1." @default.
• W2892016893 created "2018-09-27" @default.
• W2892016893 creator A5010369673 @default.
• W2892016893 creator A5032789956 @default.
• W2892016893 creator A5057752220 @default.
• W2892016893 creator A5072500012 @default.
• W2892016893 creator A5075080019 @default.
• W2892016893 creator A5077745157 @default.
• W2892016893 date "2018-09-19" @default.
• W2892016893 modified "2023-10-06" @default.
• W2892016893 title "Long non‑coding RNA LINC01503 promotes colorectal cancer cell proliferation and invasion by regulating miR‑4492/FOXK1 signaling" @default.
• W2892016893 cites W2087377443 @default.
• W2892016893 cites W2107277218 @default.
• W2892016893 cites W2129481759 @default.
• W2892016893 cites W2170552969 @default.
• W2892016893 cites W2192080449 @default.
• W2892016893 cites W2558995006 @default.
• W2892016893 cites W2560569860 @default.
• W2892016893 cites W2563183180 @default.
• W2892016893 cites W2577432673 @default.
• W2892016893 cites W2594015307 @default.
• W2892016893 cites W2603752903 @default.
• W2892016893 cites W2626800269 @default.
• W2892016893 cites W2679442683 @default.
• W2892016893 cites W2740922393 @default.
• W2892016893 cites W2765557815 @default.
• W2892016893 cites W2766004179 @default.
• W2892016893 cites W2769018197 @default.
• W2892016893 cites W2771694138 @default.
• W2892016893 cites W2773170374 @default.
• W2892016893 cites W2779840599 @default.
• W2892016893 cites W2785545196 @default.
• W2892016893 cites W2789361425 @default.
• W2892016893 cites W2790227551 @default.
• W2892016893 cites W2791431314 @default.
• W2892016893 cites W2793318975 @default.
• W2892016893 cites W2981518794 @default.
• W2892016893 doi "https://doi.org/10.3892/etm.2018.6775" @default.
• W2892016893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6257603" @default.
• W2892016893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30542444" @default.
• W2892016893 hasPublicationYear "2018" @default.
• W2892016893 type Work @default.
• W2892016893 sameAs 2892016893 @default.
• W2892016893 citedByCount "17" @default.
• W2892016893 countsByYear W28920168932019 @default.
• W2892016893 countsByYear W28920168932020 @default.
• W2892016893 countsByYear W28920168932021 @default.
• W2892016893 countsByYear W28920168932022 @default.
• W2892016893 countsByYear W28920168932023 @default.
• W2892016893 crossrefType "journal-article" @default.
• W2892016893 hasAuthorship W2892016893A5010369673 @default.
• W2892016893 hasAuthorship W2892016893A5032789956 @default.
• W2892016893 hasAuthorship W2892016893A5057752220 @default.
• W2892016893 hasAuthorship W2892016893A5072500012 @default.
• W2892016893 hasAuthorship W2892016893A5075080019 @default.
• W2892016893 hasAuthorship W2892016893A5077745157 @default.
• W2892016893 hasBestOaLocation W28920168931 @default.
• W2892016893 hasConcept C104317684 @default.
• W2892016893 hasConcept C145059251 @default.
• W2892016893 hasConcept C153911025 @default.
• W2892016893 hasConcept C173396325 @default.
• W2892016893 hasConcept C502942594 @default.
• W2892016893 hasConcept C54355233 @default.
• W2892016893 hasConcept C60365752 @default.
• W2892016893 hasConcept C62112901 @default.
• W2892016893 hasConcept C62203573 @default.
• W2892016893 hasConcept C67705224 @default.
• W2892016893 hasConcept C86803240 @default.
• W2892016893 hasConcept C95444343 @default.
• W2892016893 hasConceptScore W2892016893C104317684 @default.
• W2892016893 hasConceptScore W2892016893C145059251 @default.
• W2892016893 hasConceptScore W2892016893C153911025 @default.
• W2892016893 hasConceptScore W2892016893C173396325 @default.
• W2892016893 hasConceptScore W2892016893C502942594 @default.
• W2892016893 hasConceptScore W2892016893C54355233 @default.
• W2892016893 hasConceptScore W2892016893C60365752 @default.
• W2892016893 hasConceptScore W2892016893C62112901 @default.
• W2892016893 hasConceptScore W2892016893C62203573 @default.
• W2892016893 hasConceptScore W2892016893C67705224 @default.
• W2892016893 hasConceptScore W2892016893C86803240 @default.
• W2892016893 hasConceptScore W2892016893C95444343 @default.
• W2892016893 hasLocation W28920168931 @default.
• W2892016893 hasLocation W28920168932 @default.
• W2892016893 hasLocation W28920168933 @default.
• W2892016893 hasLocation W28920168934 @default.
• W2892016893 hasOpenAccess W2892016893 @default.
• W2892016893 hasPrimaryLocation W28920168931 @default.
• W2892016893 hasRelatedWork W2591601044 @default.
• W2892016893 hasRelatedWork W2606878667 @default.
• W2892016893 hasRelatedWork W2903968497 @default.
• W2892016893 hasRelatedWork W2947704385 @default.
• W2892016893 hasRelatedWork W2980955790 @default.
• W2892016893 hasRelatedWork W3000289148 @default.
• W2892016893 hasRelatedWork W3137568241 @default.
• W2892016893 hasRelatedWork W3202119051 @default.
• W2892016893 hasRelatedWork W4254967709 @default.
• W2892016893 hasRelatedWork W4306933290 @default.
• W2892016893 isParatext "false" @default.
• W2892016893 isRetracted "false" @default.
• W2892016893 magId "2892016893" @default.

• next