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• W2892017555 abstract "Chronic enteropathy (CE) in dogs is characterized retrospectively per treatment response as food-responsive enteropathy (FRE), antibiotic-responsive enteropathy (ARE), and immunosuppressant-responsive enteropathy (IRE) - the latter most resembling inflammatory bowel disease in people. The aim of this study was to characterize duodenal macrophages (Mϕ) in CE using immunohistochemistry; with calprotectin (CAL) as a marker of early differentiated Mϕ and CD163 expression as a marker for resident Mϕ in the duodenum before and after treatment. Prior to treatment, dogs with FRE and IRE had a lower CD163+/CAL+ ratio than control dogs (CTRL) in crypts; this increased significantly and normalized compared with CTRL after treatment. Conversely, the CD163+/CAL+ ratio in dogs with ARE was comparable to that in healthy dogs before and after treatment. In summary, these results suggest that Mϕ play a role in the pathogenesis of CE in FRE and IRE, with a decrease in resident Mϕ and an increase in early differentiated Mϕ, but not in ARE dogs. Mϕ normalize after successful treatment." @default.
• W2892017555 created "2018-09-27" @default.
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• W2892017555 date "2018-09-17" @default.
• W2892017555 modified "2023-09-27" @default.
• W2892017555 title "Changes in duodenal CD163-positive cells in dogs with chronic enteropathy after successful treatment" @default.
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• W2892017555 doi "https://doi.org/10.1177/1753425918799865" @default.
• W2892017555 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6830873" @default.
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• W2892017555 hasPublicationYear "2018" @default.
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