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- W2892023848 abstract "Abstract Diabetes mellitus affects a large number of men of reproductive age and it usually leads to serious reproductive disorders. However, the underlying mechanisms and specific therapies still remain largely unknown. We observed Leydig cell loss in the testes of diabetic mice. Continuous high glycemic status of testes stimulated expression of Caspase12, Grp78, and Chop, the three ERS response factors; this might induce cell cycle arrest and apoptosis of Leydig cells in response to ERS. In these diabetic mouse models, melatonin alleviated apoptosis of testicular stromal cell induced by ERS, and promoted SSCs self-renewal by recovering Leydig cells secretion of CSF1 after 8 weeks of treatment. To explore the relationship between CSF-1 and ERS in Leydig cells, we treated Leydig tumor cell line with an activator Tuniamycin and an inhibitor 4-Phenylbutyrate of ERS. Our data showed that the CSF-1 expression in mouse Leydig cell lines decreased six-fold while reversely increasing five-fold in the 4-Phenylbutyrate-treated group. Thus, melatonin likely alleviates the loss of Leydig cells in diabetic testes and provides a healthier niche for SSCs to self-renew and continually provide healthy sperm for male fertility." @default.
- W2892023848 created "2018-09-27" @default.
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- W2892023848 date "2018-09-20" @default.
- W2892023848 modified "2023-10-18" @default.
- W2892023848 title "Melatonin attenuates detrimental effects of diabetes on the niche of mouse spermatogonial stem cells by maintaining Leydig cells" @default.
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- W2892023848 cites W1485525899 @default.
- W2892023848 cites W1569114718 @default.
- W2892023848 cites W1570888466 @default.
- W2892023848 cites W1603272910 @default.
- W2892023848 cites W1723001059 @default.
- W2892023848 cites W1910574151 @default.
- W2892023848 cites W1972198114 @default.
- W2892023848 cites W1974817709 @default.
- W2892023848 cites W1975295430 @default.
- W2892023848 cites W1983837156 @default.
- W2892023848 cites W2000626401 @default.
- W2892023848 cites W2001714275 @default.
- W2892023848 cites W2003004843 @default.
- W2892023848 cites W2017242947 @default.
- W2892023848 cites W2021094253 @default.
- W2892023848 cites W2021743307 @default.
- W2892023848 cites W2025279968 @default.
- W2892023848 cites W2027827512 @default.
- W2892023848 cites W2031758113 @default.
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- W2892023848 cites W2059977935 @default.
- W2892023848 cites W2061153582 @default.
- W2892023848 cites W2077500590 @default.
- W2892023848 cites W2090828812 @default.
- W2892023848 cites W2096388436 @default.
- W2892023848 cites W2107668207 @default.
- W2892023848 cites W2111705682 @default.
- W2892023848 cites W2116380331 @default.
- W2892023848 cites W2118324758 @default.
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- W2892023848 cites W2135256812 @default.
- W2892023848 cites W2144134929 @default.
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- W2892023848 cites W2148441868 @default.
- W2892023848 cites W2161744364 @default.
- W2892023848 cites W2168003742 @default.
- W2892023848 cites W2171929902 @default.
- W2892023848 cites W2268527404 @default.
- W2892023848 cites W2325079716 @default.
- W2892023848 cites W2327640792 @default.
- W2892023848 cites W2476789590 @default.
- W2892023848 cites W2479394673 @default.
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- W2892023848 cites W2533491599 @default.
- W2892023848 cites W2543661053 @default.
- W2892023848 cites W2548034012 @default.
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- W2892023848 cites W2587319550 @default.
- W2892023848 cites W2589221033 @default.
- W2892023848 cites W2623970100 @default.
- W2892023848 cites W2750818786 @default.
- W2892023848 cites W2759290412 @default.
- W2892023848 cites W2768204036 @default.
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- W2892023848 doi "https://doi.org/10.1038/s41419-018-0956-4" @default.
- W2892023848 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6148071" @default.
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- W2892023848 hasPublicationYear "2018" @default.
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