Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892025499> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2892025499 abstract "3520 Background: Curative surgery is the best therapy of CRC and recurrences. We assessed whether adding semi-annual PET-CT to the usual surveillance would be cost-effective in high risk recurrent CRC patients. Methods: CRC patients (stage II tumor perforated, stages III and IV) in remission after curative surgery were randomly assigned (1:1) to trimester usual surveillance (control) or usual surveillance + semi-annual course PET-CT (intervention) for a 3-yr follow up period. Every 3 months, multidisciplinary committee decided about recurrence by yes/no/doubtful. If yes, curative surgery alone (when relevant), or chemotherapy alone (unresecable recurrence) were conducted; additional exams could be performed if doubtful. Primary composite endpoint (failure) comprised unresectable recurrence & death. The economic assessments according to standards (CHEERS) were performed and costs were compared between groups. Statistical tests for calculation of the relative risk (RR) were used and survival was analyzed using Kaplan-Meier method, Log-Rang test and Cox models. Results: Baseline characteristics of 239 patients (120/119) enrolled in 12 centers were balanced. The failure rate was 29.2% (31 unresectable recurrences & 4 deaths) and 23.5% (27 & 1) in Interventional vs Control, respectively with no significant difference (RR = 1.24, 95% CI: 0.81-1.90; P = .32). Similar results were observed in multivariate analysis (Cox models) adjusted for stage and tumor differentiation (HR = 1.33, 95% CI: 0.8-2.19, P = .27). Period until the unresectable recurrence was significantly shorter in Interventional (median = 7; IQR: 3-20 months) than in Control group (14.3; 7.3-27; P= 0.016). This was consistent with lower elevation (median; IQR) of tumour marker in interventional (3.8; 2.8-19) than in control group (10; 5.2-28.6) at the first recurrence time as compared to the baseline (p = 0.007). Overall (mean; SD) cost (euros)/patient was higher in the PET-Scan (9385; 11658) than in the control group (7027; 7656). Conclusions: Although recurrences were detected earlier in PET-CT group, the strategy was less effective, more expensive. This exam should not be advised routinely. Clinical trial information: NCT 00624260." @default.
- W2892025499 created "2018-09-27" @default.
- W2892025499 creator A5002802285 @default.
- W2892025499 creator A5007684263 @default.
- W2892025499 creator A5012882107 @default.
- W2892025499 creator A5018129015 @default.
- W2892025499 creator A5018281181 @default.
- W2892025499 creator A5020893157 @default.
- W2892025499 creator A5024180743 @default.
- W2892025499 creator A5034615782 @default.
- W2892025499 creator A5040985815 @default.
- W2892025499 creator A5041789610 @default.
- W2892025499 creator A5059091077 @default.
- W2892025499 creator A5061710022 @default.
- W2892025499 creator A5065617907 @default.
- W2892025499 creator A5079480540 @default.
- W2892025499 creator A5083141882 @default.
- W2892025499 creator A5085121407 @default.
- W2892025499 creator A5089394297 @default.
- W2892025499 date "2017-05-20" @default.
- W2892025499 modified "2023-10-03" @default.
- W2892025499 title "Colorectal cancer (CRC) patients surveyed by 18FDGPET-CT (PET-CT): An open-label multicenter randomized trial (NCT 00624260)." @default.
- W2892025499 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.3520" @default.
- W2892025499 hasPublicationYear "2017" @default.
- W2892025499 type Work @default.
- W2892025499 sameAs 2892025499 @default.
- W2892025499 citedByCount "2" @default.
- W2892025499 countsByYear W28920254992017 @default.
- W2892025499 countsByYear W28920254992019 @default.
- W2892025499 crossrefType "journal-article" @default.
- W2892025499 hasAuthorship W2892025499A5002802285 @default.
- W2892025499 hasAuthorship W2892025499A5007684263 @default.
- W2892025499 hasAuthorship W2892025499A5012882107 @default.
- W2892025499 hasAuthorship W2892025499A5018129015 @default.
- W2892025499 hasAuthorship W2892025499A5018281181 @default.
- W2892025499 hasAuthorship W2892025499A5020893157 @default.
- W2892025499 hasAuthorship W2892025499A5024180743 @default.
- W2892025499 hasAuthorship W2892025499A5034615782 @default.
- W2892025499 hasAuthorship W2892025499A5040985815 @default.
- W2892025499 hasAuthorship W2892025499A5041789610 @default.
- W2892025499 hasAuthorship W2892025499A5059091077 @default.
- W2892025499 hasAuthorship W2892025499A5061710022 @default.
- W2892025499 hasAuthorship W2892025499A5065617907 @default.
- W2892025499 hasAuthorship W2892025499A5079480540 @default.
- W2892025499 hasAuthorship W2892025499A5083141882 @default.
- W2892025499 hasAuthorship W2892025499A5085121407 @default.
- W2892025499 hasAuthorship W2892025499A5089394297 @default.
- W2892025499 hasConcept C121608353 @default.
- W2892025499 hasConcept C126322002 @default.
- W2892025499 hasConcept C126838900 @default.
- W2892025499 hasConcept C143998085 @default.
- W2892025499 hasConcept C168563851 @default.
- W2892025499 hasConcept C2989005 @default.
- W2892025499 hasConcept C3019800554 @default.
- W2892025499 hasConcept C526805850 @default.
- W2892025499 hasConcept C71924100 @default.
- W2892025499 hasConceptScore W2892025499C121608353 @default.
- W2892025499 hasConceptScore W2892025499C126322002 @default.
- W2892025499 hasConceptScore W2892025499C126838900 @default.
- W2892025499 hasConceptScore W2892025499C143998085 @default.
- W2892025499 hasConceptScore W2892025499C168563851 @default.
- W2892025499 hasConceptScore W2892025499C2989005 @default.
- W2892025499 hasConceptScore W2892025499C3019800554 @default.
- W2892025499 hasConceptScore W2892025499C526805850 @default.
- W2892025499 hasConceptScore W2892025499C71924100 @default.
- W2892025499 hasLocation W28920254991 @default.
- W2892025499 hasOpenAccess W2892025499 @default.
- W2892025499 hasPrimaryLocation W28920254991 @default.
- W2892025499 hasRelatedWork W1993303368 @default.
- W2892025499 hasRelatedWork W2214259081 @default.
- W2892025499 hasRelatedWork W2227951854 @default.
- W2892025499 hasRelatedWork W2277646258 @default.
- W2892025499 hasRelatedWork W2442110270 @default.
- W2892025499 hasRelatedWork W2590022720 @default.
- W2892025499 hasRelatedWork W2590326662 @default.
- W2892025499 hasRelatedWork W2595823084 @default.
- W2892025499 hasRelatedWork W2598842647 @default.
- W2892025499 hasRelatedWork W2603706455 @default.
- W2892025499 hasRelatedWork W2624324938 @default.
- W2892025499 hasRelatedWork W2789521687 @default.
- W2892025499 hasRelatedWork W2889172204 @default.
- W2892025499 hasRelatedWork W3027618744 @default.
- W2892025499 hasRelatedWork W3080226635 @default.
- W2892025499 hasRelatedWork W3111747864 @default.
- W2892025499 hasRelatedWork W3199118097 @default.
- W2892025499 hasRelatedWork W3207584387 @default.
- W2892025499 hasRelatedWork W3210179852 @default.
- W2892025499 hasRelatedWork W2554011870 @default.
- W2892025499 isParatext "false" @default.
- W2892025499 isRetracted "false" @default.
- W2892025499 magId "2892025499" @default.
- W2892025499 workType "article" @default.