FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892028585> ?p ?o ?g. }

• W2892028585 endingPage "2547" @default.
• W2892028585 startingPage "2539" @default.
• W2892028585 abstract "Opioid receptors are implicated in alcoholism, other addictions, withdrawal, and depression, and are considered potential pharmacological targets for treatment. Our goal in the present study was to compare the availability of kappa opioid receptors (KOR) between an alcohol-dependent cohort (AD) and a healthy control cohort (HC). Sixty-four participants-36 AD and 28 HC-underwent PET scans with [11C]LY2795050, a selective kappa antagonist tracer. Partial-volume correction was applied to all PET data to correct for atrophy. Volume of distribution (VT) of the tracer was estimated regionally as a measure of KOR availability. VT values of AD versus HC were compared for 15 defined ROIs. Multivariate analysis showed a main effect of group on VT across these 15 ROIs. Post hoc tests showed that AD had significantly lower VT and thus a lower KOR availability than HC in amygdala and pallidum (corrected for multiple comparisons). Exploratory analysis of change in VT with age was conducted; VT was not found to vary significantly with age in any region. Our findings of lower VT in AD versus HC in multiple regions are in contrast to findings in the mu and delta opioid receptor systems of higher VT in AD versus HC. Although age-related decline in receptors has previously been observed in the mu opioid receptor system, we found that KOR availability does not change with age." @default.
• W2892028585 created "2018-09-27" @default.
• W2892028585 creator A5003324009 @default.
• W2892028585 creator A5004932337 @default.
• W2892028585 creator A5006508700 @default.
• W2892028585 creator A5016471369 @default.
• W2892028585 creator A5041759566 @default.
• W2892028585 creator A5048526055 @default.
• W2892028585 creator A5060318454 @default.
• W2892028585 creator A5085115121 @default.
• W2892028585 date "2018-09-06" @default.
• W2892028585 modified "2023-10-18" @default.
• W2892028585 title "PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age" @default.
• W2892028585 cites W1475474724 @default.
• W2892028585 cites W1569134566 @default.
• W2892028585 cites W1965472158 @default.
• W2892028585 cites W1970015881 @default.
• W2892028585 cites W1971353040 @default.
• W2892028585 cites W1986611370 @default.
• W2892028585 cites W1988922574 @default.
• W2892028585 cites W2002911679 @default.
• W2892028585 cites W2002947893 @default.
• W2892028585 cites W2004537679 @default.
• W2892028585 cites W2005172706 @default.
• W2892028585 cites W2005523377 @default.
• W2892028585 cites W2006992423 @default.
• W2892028585 cites W2010455608 @default.
• W2892028585 cites W2014344383 @default.
• W2892028585 cites W2015046028 @default.
• W2892028585 cites W2016194465 @default.
• W2892028585 cites W2017201759 @default.
• W2892028585 cites W2017709022 @default.
• W2892028585 cites W2020898323 @default.
• W2892028585 cites W2021066246 @default.
• W2892028585 cites W2021349110 @default.
• W2892028585 cites W2022304562 @default.
• W2892028585 cites W2024365408 @default.
• W2892028585 cites W2029313053 @default.
• W2892028585 cites W2046700062 @default.
• W2892028585 cites W2047762719 @default.
• W2892028585 cites W2056000609 @default.
• W2892028585 cites W2058046532 @default.
• W2892028585 cites W2064449076 @default.
• W2892028585 cites W2065522791 @default.
• W2892028585 cites W2076078537 @default.
• W2892028585 cites W2076507162 @default.
• W2892028585 cites W2078718738 @default.
• W2892028585 cites W2084450389 @default.
• W2892028585 cites W2095336616 @default.
• W2892028585 cites W2100705061 @default.
• W2892028585 cites W2104284600 @default.
• W2892028585 cites W2107472486 @default.
• W2892028585 cites W2107970821 @default.
• W2892028585 cites W2112278807 @default.
• W2892028585 cites W2115600994 @default.
• W2892028585 cites W2116354423 @default.
• W2892028585 cites W2118061336 @default.
• W2892028585 cites W2121686982 @default.
• W2892028585 cites W2123282949 @default.
• W2892028585 cites W2123705561 @default.
• W2892028585 cites W2123830992 @default.
• W2892028585 cites W2126709720 @default.
• W2892028585 cites W2127506107 @default.
• W2892028585 cites W2135057136 @default.
• W2892028585 cites W2135492979 @default.
• W2892028585 cites W2137578444 @default.
• W2892028585 cites W2144244386 @default.
• W2892028585 cites W2157347951 @default.
• W2892028585 cites W2162688555 @default.
• W2892028585 cites W2163542677 @default.
• W2892028585 cites W2166284137 @default.
• W2892028585 cites W2166462402 @default.
• W2892028585 cites W2172323892 @default.
• W2892028585 cites W2222733422 @default.
• W2892028585 cites W2234927368 @default.
• W2892028585 cites W2272581048 @default.
• W2892028585 cites W2334557001 @default.
• W2892028585 cites W2534384157 @default.
• W2892028585 cites W2577261981 @default.
• W2892028585 cites W2583859727 @default.
• W2892028585 cites W2612528709 @default.
• W2892028585 doi "https://doi.org/10.1038/s41386-018-0199-1" @default.
• W2892028585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6224533" @default.
• W2892028585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30188515" @default.
• W2892028585 hasPublicationYear "2018" @default.
• W2892028585 type Work @default.
• W2892028585 sameAs 2892028585 @default.
• W2892028585 citedByCount "33" @default.
• W2892028585 countsByYear W28920285852019 @default.
• W2892028585 countsByYear W28920285852020 @default.
• W2892028585 countsByYear W28920285852021 @default.
• W2892028585 countsByYear W28920285852022 @default.
• W2892028585 countsByYear W28920285852023 @default.
• W2892028585 crossrefType "journal-article" @default.
• W2892028585 hasAuthorship W2892028585A5003324009 @default.
• W2892028585 hasAuthorship W2892028585A5004932337 @default.
• W2892028585 hasAuthorship W2892028585A5006508700 @default.
• W2892028585 hasAuthorship W2892028585A5016471369 @default.

• next