FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892040378> ?p ?o ?g. }

• W2892040378 endingPage "2425" @default.
• W2892040378 startingPage "2425" @default.
• W2892040378 abstract "Non-steroidal anti-inflammatory drugs (NSAIDs) are an important pharmacological class of drugs used for the treatment of inflammatory diseases. They are also characterized by severe side effects, such as gastrointestinal damage, increased cardiovascular risk and renal function abnormalities. In order to synthesize new anti-inflammatory and analgesic compounds with a safer profile of side effects, a series of 2,6-diaryl-imidazo[2,1-b][1,3,4]thiadiazole derivatives 5a–l were synthesized and evaluated in vivo for their anti-inflammatory and analgesic activities in carrageenan-induced rat paw edema. Among all compounds, 5c showed better anti-inflammatory activity compared to diclofenac, the standard drug, and compounds 5g, 5i, 5j presented a comparable antinociceptive activity to diclofenac. None of the compounds showed ulcerogenic activity. Molecular docking studies were carried out to investigate the theoretical bond interactions between the compounds and target, the cyclooxygenases (COX-1/COX-2). The compound 5c exhibited a higher inhibition of COX-2 compared to diclofenac." @default.
• W2892040378 created "2018-09-27" @default.
• W2892040378 creator A5001751512 @default.
• W2892040378 creator A5002873622 @default.
• W2892040378 creator A5009187973 @default.
• W2892040378 creator A5014664792 @default.
• W2892040378 creator A5051737106 @default.
• W2892040378 creator A5053604481 @default.
• W2892040378 creator A5053753880 @default.
• W2892040378 creator A5055013110 @default.
• W2892040378 creator A5086075393 @default.
• W2892040378 date "2018-09-21" @default.
• W2892040378 modified "2023-10-18" @default.
• W2892040378 title "Heterocycles 48. Synthesis, Characterization and Biological Evaluation of Imidazo[2,1-b][1,3,4]Thiadiazole Derivatives as Anti-Inflammatory Agents" @default.
• W2892040378 cites W1480874656 @default.
• W2892040378 cites W1503834335 @default.
• W2892040378 cites W1967190421 @default.
• W2892040378 cites W1969983782 @default.
• W2892040378 cites W1975479648 @default.
• W2892040378 cites W1981819970 @default.
• W2892040378 cites W1986240377 @default.
• W2892040378 cites W1987117203 @default.
• W2892040378 cites W1993594749 @default.
• W2892040378 cites W1994868841 @default.
• W2892040378 cites W1996462445 @default.
• W2892040378 cites W1997208118 @default.
• W2892040378 cites W2008259104 @default.
• W2892040378 cites W2019896206 @default.
• W2892040378 cites W2023232134 @default.
• W2892040378 cites W2028359846 @default.
• W2892040378 cites W2030850720 @default.
• W2892040378 cites W2032723157 @default.
• W2892040378 cites W2041161846 @default.
• W2892040378 cites W2047527113 @default.
• W2892040378 cites W2061505401 @default.
• W2892040378 cites W2065833668 @default.
• W2892040378 cites W2082502327 @default.
• W2892040378 cites W2092196012 @default.
• W2892040378 cites W2105668062 @default.
• W2892040378 cites W2116448170 @default.
• W2892040378 cites W2127322768 @default.
• W2892040378 cites W2132629607 @default.
• W2892040378 cites W2133971099 @default.
• W2892040378 cites W2147921405 @default.
• W2892040378 cites W2149525061 @default.
• W2892040378 cites W2156826334 @default.
• W2892040378 cites W2158714788 @default.
• W2892040378 cites W2158960911 @default.
• W2892040378 cites W2159973565 @default.
• W2892040378 cites W2222956685 @default.
• W2892040378 cites W2256167805 @default.
• W2892040378 cites W2261454648 @default.
• W2892040378 cites W2262538191 @default.
• W2892040378 cites W2462492291 @default.
• W2892040378 cites W2564129069 @default.
• W2892040378 cites W2586752167 @default.
• W2892040378 cites W2587777980 @default.
• W2892040378 cites W2608808791 @default.
• W2892040378 cites W2655278607 @default.
• W2892040378 cites W2786858370 @default.
• W2892040378 cites W2794233815 @default.
• W2892040378 cites W2892040378 @default.
• W2892040378 cites W2951924765 @default.
• W2892040378 cites W2952110646 @default.
• W2892040378 doi "https://doi.org/10.3390/molecules23102425" @default.
• W2892040378 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6222387" @default.
• W2892040378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30248903" @default.
• W2892040378 hasPublicationYear "2018" @default.
• W2892040378 type Work @default.
• W2892040378 sameAs 2892040378 @default.
• W2892040378 citedByCount "19" @default.
• W2892040378 countsByYear W28920403782019 @default.
• W2892040378 countsByYear W28920403782020 @default.
• W2892040378 countsByYear W28920403782021 @default.
• W2892040378 countsByYear W28920403782022 @default.
• W2892040378 countsByYear W28920403782023 @default.
• W2892040378 crossrefType "journal-article" @default.
• W2892040378 hasAuthorship W2892040378A5001751512 @default.
• W2892040378 hasAuthorship W2892040378A5002873622 @default.
• W2892040378 hasAuthorship W2892040378A5009187973 @default.
• W2892040378 hasAuthorship W2892040378A5014664792 @default.
• W2892040378 hasAuthorship W2892040378A5051737106 @default.
• W2892040378 hasAuthorship W2892040378A5053604481 @default.
• W2892040378 hasAuthorship W2892040378A5053753880 @default.
• W2892040378 hasAuthorship W2892040378A5055013110 @default.
• W2892040378 hasAuthorship W2892040378A5086075393 @default.
• W2892040378 hasBestOaLocation W28920403781 @default.
• W2892040378 hasConcept C150903083 @default.
• W2892040378 hasConcept C185592680 @default.
• W2892040378 hasConcept C207001950 @default.
• W2892040378 hasConcept C2779703632 @default.
• W2892040378 hasConcept C2779826273 @default.
• W2892040378 hasConcept C2780035454 @default.
• W2892040378 hasConcept C2780820201 @default.
• W2892040378 hasConcept C2781227287 @default.
• W2892040378 hasConcept C71240020 @default.
• W2892040378 hasConcept C71924100 @default.
• W2892040378 hasConcept C86803240 @default.

• next