FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892040407> ?p ?o ?g. }

• W2892040407 abstract "4050 Background: We recently showed that cancer cells, with proliferative and tumorigenic potential, can spill into the peritoneal cavity during curative (R0) gastric cancer (GC) surgery, which is associated with peritoneal recurrence (PM). To elucidate the pathophysiology of PM, the relationship between spilled cancer cells and cancer stem cells was evaluated. Furthermore, to identify a therapeutic strategy for PM, the prognostic impact of hyperthermic intraperitoneal chemotherapy (HIPEC) following GC surgery with spillage of cancer cells was evaluated. Methods: Patients with advanced GC (≥pT2 [MP]) who underwent R0 gastrectomy between 2010 and 2015 were enrolled. Ninety-four consecutive patients with negative results in peritoneal cytology and cancer cell culture (CCC [-]) following peritoneal washing (PW) before GC surgery were included. Spilled cancer cells in PW after GC surgery (PW-Post) were examined to identify any CD44-positive cancer stem-like cells associated with cancer metastasis. Based on the PW-Post CCC results, associations between HIPEC and recurrence-free survival (RFS), or overall survival (OS) were evaluated. HIPEC was performed following GC surgery using CDDP, MMC, and 5-FU in 5 L saline maintained at 42 ˚ C for 30 min. Results: Spilled cancer cells included CD44 + cancer stem-like cells. In 48 patients with PW-Post positive CCC (CCC [+]), the number of patients with pStage I, II, and III were 4, 7, and 15, respectively, in those who received HIPEC (n = 26), and 3, 9, and 10, respectively, in those who did not (n = 22). Among patients with CCC (+), the 5-year peritoneal RFS, hepatic RFS, and lymph node RFS rates were 93.3%, 100%, and 68.5%, respectively, in patients who received HIPEC, and 56.7%, 35.6%, and 66.7%, respectively, in those who did not ( P = 0.008, P = 0.008, and P= 0.24, respectively). Among patients with PW-Post CCC (-), none developed recurrence, regardless of whether they received HIPEC (n = 28) or not (n = 18). Conclusions: The results show that PW-Post CCC is a promising predictive biomarker for recurrence after R0 GC surgery. Adjuvant HIPEC performed with R0 GC surgery showed preventive effects on peritoneal and hepatic recurrence and survival benefits for patients with PW-Post CCC (+)." @default.
• W2892040407 created "2018-09-27" @default.
• W2892040407 creator A5000745938 @default.
• W2892040407 creator A5001365038 @default.
• W2892040407 creator A5002660977 @default.
• W2892040407 creator A5003031331 @default.
• W2892040407 creator A5010145256 @default.
• W2892040407 creator A5014286145 @default.
• W2892040407 creator A5016476726 @default.
• W2892040407 creator A5019814023 @default.
• W2892040407 creator A5024695820 @default.
• W2892040407 creator A5026105894 @default.
• W2892040407 creator A5038963840 @default.
• W2892040407 creator A5041506585 @default.
• W2892040407 creator A5046105983 @default.
• W2892040407 creator A5058284228 @default.
• W2892040407 creator A5060366654 @default.
• W2892040407 creator A5068808260 @default.
• W2892040407 creator A5073221100 @default.
• W2892040407 creator A5079767486 @default.
• W2892040407 creator A5086132249 @default.
• W2892040407 creator A5087830403 @default.
• W2892040407 date "2017-05-20" @default.
• W2892040407 modified "2023-09-27" @default.
• W2892040407 title "Pathophysiology and therapeutic strategies for peritoneal recurrence after gastric cancer surgery." @default.
• W2892040407 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.4050" @default.
• W2892040407 hasPublicationYear "2017" @default.
• W2892040407 type Work @default.
• W2892040407 sameAs 2892040407 @default.
• W2892040407 citedByCount "0" @default.
• W2892040407 crossrefType "journal-article" @default.
• W2892040407 hasAuthorship W2892040407A5000745938 @default.
• W2892040407 hasAuthorship W2892040407A5001365038 @default.
• W2892040407 hasAuthorship W2892040407A5002660977 @default.
• W2892040407 hasAuthorship W2892040407A5003031331 @default.
• W2892040407 hasAuthorship W2892040407A5010145256 @default.
• W2892040407 hasAuthorship W2892040407A5014286145 @default.
• W2892040407 hasAuthorship W2892040407A5016476726 @default.
• W2892040407 hasAuthorship W2892040407A5019814023 @default.
• W2892040407 hasAuthorship W2892040407A5024695820 @default.
• W2892040407 hasAuthorship W2892040407A5026105894 @default.
• W2892040407 hasAuthorship W2892040407A5038963840 @default.
• W2892040407 hasAuthorship W2892040407A5041506585 @default.
• W2892040407 hasAuthorship W2892040407A5046105983 @default.
• W2892040407 hasAuthorship W2892040407A5058284228 @default.
• W2892040407 hasAuthorship W2892040407A5060366654 @default.
• W2892040407 hasAuthorship W2892040407A5068808260 @default.
• W2892040407 hasAuthorship W2892040407A5073221100 @default.
• W2892040407 hasAuthorship W2892040407A5079767486 @default.
• W2892040407 hasAuthorship W2892040407A5086132249 @default.
• W2892040407 hasAuthorship W2892040407A5087830403 @default.
• W2892040407 hasConcept C10162356 @default.
• W2892040407 hasConcept C121608353 @default.
• W2892040407 hasConcept C126322002 @default.
• W2892040407 hasConcept C141071460 @default.
• W2892040407 hasConcept C2991678472 @default.
• W2892040407 hasConcept C2992687050 @default.
• W2892040407 hasConcept C71924100 @default.
• W2892040407 hasConceptScore W2892040407C10162356 @default.
• W2892040407 hasConceptScore W2892040407C121608353 @default.
• W2892040407 hasConceptScore W2892040407C126322002 @default.
• W2892040407 hasConceptScore W2892040407C141071460 @default.
• W2892040407 hasConceptScore W2892040407C2991678472 @default.
• W2892040407 hasConceptScore W2892040407C2992687050 @default.
• W2892040407 hasConceptScore W2892040407C71924100 @default.
• W2892040407 hasLocation W28920404071 @default.
• W2892040407 hasOpenAccess W2892040407 @default.
• W2892040407 hasPrimaryLocation W28920404071 @default.
• W2892040407 isParatext "false" @default.
• W2892040407 isRetracted "false" @default.
• W2892040407 magId "2892040407" @default.
• W2892040407 workType "article" @default.