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- W2892044968 abstract "Down syndrome cell adhesion molecules (DSCAMs) are broadly expressed in nervous systems and play conserved roles in programmed cell death, neuronal migration, axon guidance, neurite branching and spacing, and synaptic targeting. However, DSCAMs appear to have distinct functions in different vertebrate animals, and little is known about their functions outside the retina. We leveraged the genetic tractability and optical accessibility of larval zebrafish to investigate the expression and function of a DSCAM family member, dscamb. Using targeted genome editing to create transgenic reporters and loss-of-function mutant alleles, we discovered that dscamb is expressed broadly throughout the brain, spinal cord, and peripheral nervous system, but is not required for overall structural organization of the brain. Despite the absence of obvious anatomical defects, homozygous dscamb mutants were deficient in their ability to ingest food and rarely survived to adulthood. Thus, we have discovered a novel function for dscamb in feeding behavior. The mutant and transgenic lines generated in these studies will provide valuable tools for identifying the molecular and cellular bases of these behaviors." @default.
- W2892044968 created "2018-09-27" @default.
- W2892044968 creator A5010989042 @default.
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- W2892044968 date "2018-09-11" @default.
- W2892044968 modified "2023-10-12" @default.
- W2892044968 title "Zebrafish expression reporters and mutants reveal that the IgSF cell adhesion molecule Dscamb is required for feeding and survival" @default.
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- W2892044968 doi "https://doi.org/10.1080/01677063.2018.1493479" @default.
- W2892044968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6464818" @default.
- W2892044968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30204029" @default.
- W2892044968 hasPublicationYear "2018" @default.
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