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• W2892050048 abstract "Purpose Previously we have shown that using sequential CT images is superior to sequential SPECT for nonrigid registration in three‐dimensional (3D) targeted radionuclide therapy ( TRT ) dosimetry. However, sequential CT s are often not available due to radiation concerns. In this paper, we propose a virtual CT ( vCT ) method for attenuation and scatter correction, image registration, and segmentation for improved dosimetric accuracy with single CT acquisition. Methods We used a population of nine XCAT phantoms with different In‐111 Zevalin biokinetics and anatomical variations for the simulations. An analytical projector was used to simulate sequential SPECT / CT acquisitions for a medium energy general purpose collimator at 1, 12, 24, 72, and 144 h postinjection, modeling attenuation, scatter, and geometric collimator‐detector response. The corresponding sequential attenuation maps of the phantoms served as real CT ( rCT ) images. For vCT generation, we investigated three registration methods, that is, (a) SPECT to SPECT ; (b) SPECT to CT , and (c) CT to SPECT , and the optimal time point for single CT acquisition. Difference images and average normalized mean square errors ( NMSE ) were calculated between different vCT s and their corresponding rCT s. Absorbed dose and dose‐volume histograms ( DVH s) for critical organs were computed for the rCT , optimized vCT , and conventional single CT (1 CT ) protocols, respectively, for dosimetric analyses. Results For vCT generation, SPECT to SPECT registration with a single CT acquired at the first time point shows the smallest difference and NMSE . For organ absorbed doses, the results of vCT were similar to those of rCT and were superior to 1 CT , that is, −0.24 ± 1.56% vs −0.49 ± 1.76% vs −6.37 ± 5.63% for the liver, −1.05 ± 2.89% vs −0.69 ± 2.74% vs −4.87 ± 4.35% for kidneys, respectively. The results of DVH s also showed improvement for all organs using vCT s as compared to the conventional 1 CT protocol. Conclusion The optimized vCT method can effectively increase the TRT dosimetric results if there is only a single CT available in the sequential imaging protocol, reducing the substantial increase in radiation burden from repeated CT scans." @default.
• W2892050048 created "2018-09-27" @default.
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• W2892050048 date "2018-10-10" @default.
• W2892050048 modified "2023-10-15" @default.
• W2892050048 title "Technical Note: Virtual <scp>CT</scp> for reducing <scp>CT</scp> dose in targeted radionuclide therapy dosimetry" @default.
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• W2892050048 doi "https://doi.org/10.1002/mp.13197" @default.
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