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• W2892053834 endingPage "2769" @default.
• W2892053834 startingPage "2762" @default.
• W2892053834 abstract "Oral cavity cancer is the most commonly occurring malignancy of the head and neck. There are limited data suggesting a change in prognosis of oral cavity cancers. We aimed to evaluate temporal trends in demographics, treatment, and prognosis of oral cavity cancer diagnosed between 1973 and 2014 inclusive.Retrospective database analysis.A retrospective study of 16,030 adult patients diagnosed with oral cavity cancer between 1973 and 2014 inclusive and treated surgically in the Surveillance, Epidemiology, and End Results (SEER) 9 registry was conducted. A supplemental analysis was conducted using data from the National Cancer Database. Multivariate Cox survival regressions and univariate Kaplan-Meier analyses were conducted.The prognosis of both early- and late-stage disease has significantly improved between 1973 and 2014. Among patients with early-stage disease, 3-year survival increased from 78.0% (standard error [SE] = 1.3) for those diagnosed from 1973 to 1980 to 92.2% (SE = 1.1) for those diagnosed from 2011 to 2014. Among patients with late-stage disease, 3-year survival ranged from 51.9% (SE = 1.5) for those diagnosed from 1973 to 1980 to 70.3% (SE = 1.9) for those diagnosed from 2011 to 2014. For patients with late-stage disease, this improved prognosis occurred in tandem with increasing usage of chemoradiotherapy as adjuvant therapy. There has also been increasing utilization of neck dissection for early- and late-stage disease, along with higher nodal yields from performed dissections.The prognosis of oral cavity cancer has improved significantly from the early 1970s to recent years. In late-stage oral cancer, this change has been associated with an increased use of adjuvant therapy and adjuvant chemoradiotherapy in particular.4 Laryngoscope, 128:2762-2769, 2018." @default.
• W2892053834 created "2018-09-27" @default.
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• W2892053834 date "2018-09-07" @default.
• W2892053834 modified "2023-09-29" @default.
• W2892053834 title "Changing prognosis of oral cancer: An analysis of survival and treatment between 1973 and 2014" @default.
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• W2892053834 doi "https://doi.org/10.1002/lary.27315" @default.
• W2892053834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30194691" @default.
• W2892053834 hasPublicationYear "2018" @default.
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