Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892054610> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2892054610 abstract "e23191 Background: Microsatellite instability-high status (MSI-H) and alterations in the DNA mismatch repair pathway associate with the efficacy of 5-FU and immune checkpoint inhibitors in patients with gastrointestinal cancers. The activin type II receptor (ACVR2) that binds to the transforming growth factor beta superfamily of ligands is frequently mutated in MSI-H colorectal cancer. However, the incidence of ACVR2 mutations in gastric cancer patients remains unclear. The aim of this study is to reveal the incidence and to examine the association between the MSI-H and ACVR2A mutations in gastric cancer patients. Methods: 124 archived FFPE gastric cancer tissues (stage I-IV), who were operated at Niigata University Medical and Dental Hospital or Niigata Cancer Center Hospital, were analyzed for ACVR2A mutation and MSI status with the NGS-based comprehensive genomic test platform. Clinicopathological characteristics of the patients were also examined. Results: All 124 gastric cancer patients were successfully analyzed. 13 out of 124 patients (10.4%) showed MSI-H status. Interestingly, 10 of 13 MSI-H patients (76.9%) showed ACVR2A mutation, where none (0%) was found among patients with microsatellite stable status (P < 0.001), indicating the strong association between ACVR2A mutation and MSI status in gastric cancer patients. In the ACVR2A mutated group, there was a female predominance (P < 0.05), and cancers of the lower part of the stomach were more common (P < 0.05), compared with the wild type group. Only one of 10 patients with ACVR2A mutation died, and the patients with ACVR2A mutation show a 5-year overall survival rate of 90%. No statistically significant difference in survival was achieved between patients with ACVR2A mutation and wild type; this is probably due to the small number of patients. Conclusions: 10 of 13 MSI-H patients showed ACVR2A mutation. Our results indicate a strong association between ACVR2A mutation and MSI-H in gastric cancer patients." @default.
- W2892054610 created "2018-09-27" @default.
- W2892054610 creator A5000846644 @default.
- W2892054610 creator A5014145916 @default.
- W2892054610 creator A5019278166 @default.
- W2892054610 creator A5025995147 @default.
- W2892054610 creator A5036289394 @default.
- W2892054610 creator A5036438602 @default.
- W2892054610 creator A5038860862 @default.
- W2892054610 creator A5040191987 @default.
- W2892054610 creator A5056655144 @default.
- W2892054610 creator A5056915467 @default.
- W2892054610 creator A5057255416 @default.
- W2892054610 creator A5060091612 @default.
- W2892054610 creator A5060702089 @default.
- W2892054610 creator A5062655330 @default.
- W2892054610 creator A5067160675 @default.
- W2892054610 creator A5081160218 @default.
- W2892054610 creator A5087348287 @default.
- W2892054610 date "2017-05-20" @default.
- W2892054610 modified "2023-09-22" @default.
- W2892054610 title "Association of activin type II receptor mutation with microsatellite instability in gastric cancer." @default.
- W2892054610 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.e23191" @default.
- W2892054610 hasPublicationYear "2017" @default.
- W2892054610 type Work @default.
- W2892054610 sameAs 2892054610 @default.
- W2892054610 citedByCount "1" @default.
- W2892054610 countsByYear W28920546102019 @default.
- W2892054610 crossrefType "journal-article" @default.
- W2892054610 hasAuthorship W2892054610A5000846644 @default.
- W2892054610 hasAuthorship W2892054610A5014145916 @default.
- W2892054610 hasAuthorship W2892054610A5019278166 @default.
- W2892054610 hasAuthorship W2892054610A5025995147 @default.
- W2892054610 hasAuthorship W2892054610A5036289394 @default.
- W2892054610 hasAuthorship W2892054610A5036438602 @default.
- W2892054610 hasAuthorship W2892054610A5038860862 @default.
- W2892054610 hasAuthorship W2892054610A5040191987 @default.
- W2892054610 hasAuthorship W2892054610A5056655144 @default.
- W2892054610 hasAuthorship W2892054610A5056915467 @default.
- W2892054610 hasAuthorship W2892054610A5057255416 @default.
- W2892054610 hasAuthorship W2892054610A5060091612 @default.
- W2892054610 hasAuthorship W2892054610A5060702089 @default.
- W2892054610 hasAuthorship W2892054610A5062655330 @default.
- W2892054610 hasAuthorship W2892054610A5067160675 @default.
- W2892054610 hasAuthorship W2892054610A5081160218 @default.
- W2892054610 hasAuthorship W2892054610A5087348287 @default.
- W2892054610 hasConcept C104317684 @default.
- W2892054610 hasConcept C121608353 @default.
- W2892054610 hasConcept C126322002 @default.
- W2892054610 hasConcept C143998085 @default.
- W2892054610 hasConcept C180754005 @default.
- W2892054610 hasConcept C2779767149 @default.
- W2892054610 hasConcept C501734568 @default.
- W2892054610 hasConcept C502942594 @default.
- W2892054610 hasConcept C54355233 @default.
- W2892054610 hasConcept C61320498 @default.
- W2892054610 hasConcept C71924100 @default.
- W2892054610 hasConcept C86803240 @default.
- W2892054610 hasConceptScore W2892054610C104317684 @default.
- W2892054610 hasConceptScore W2892054610C121608353 @default.
- W2892054610 hasConceptScore W2892054610C126322002 @default.
- W2892054610 hasConceptScore W2892054610C143998085 @default.
- W2892054610 hasConceptScore W2892054610C180754005 @default.
- W2892054610 hasConceptScore W2892054610C2779767149 @default.
- W2892054610 hasConceptScore W2892054610C501734568 @default.
- W2892054610 hasConceptScore W2892054610C502942594 @default.
- W2892054610 hasConceptScore W2892054610C54355233 @default.
- W2892054610 hasConceptScore W2892054610C61320498 @default.
- W2892054610 hasConceptScore W2892054610C71924100 @default.
- W2892054610 hasConceptScore W2892054610C86803240 @default.
- W2892054610 hasLocation W28920546101 @default.
- W2892054610 hasOpenAccess W2892054610 @default.
- W2892054610 hasPrimaryLocation W28920546101 @default.
- W2892054610 hasRelatedWork W1550947435 @default.
- W2892054610 hasRelatedWork W1983449890 @default.
- W2892054610 hasRelatedWork W2009029946 @default.
- W2892054610 hasRelatedWork W2010494005 @default.
- W2892054610 hasRelatedWork W2015702415 @default.
- W2892054610 hasRelatedWork W2039456155 @default.
- W2892054610 hasRelatedWork W204393960 @default.
- W2892054610 hasRelatedWork W2051884459 @default.
- W2892054610 hasRelatedWork W2090319155 @default.
- W2892054610 hasRelatedWork W2092670592 @default.
- W2892054610 hasRelatedWork W2093204178 @default.
- W2892054610 hasRelatedWork W2160543963 @default.
- W2892054610 hasRelatedWork W2223917896 @default.
- W2892054610 hasRelatedWork W2258644480 @default.
- W2892054610 hasRelatedWork W2600889039 @default.
- W2892054610 hasRelatedWork W2751045767 @default.
- W2892054610 hasRelatedWork W2833897353 @default.
- W2892054610 hasRelatedWork W2947622825 @default.
- W2892054610 hasRelatedWork W3007380682 @default.
- W2892054610 hasRelatedWork W3111184602 @default.
- W2892054610 isParatext "false" @default.
- W2892054610 isRetracted "false" @default.
- W2892054610 magId "2892054610" @default.
- W2892054610 workType "article" @default.