Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892055825> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2892055825 abstract "High-risk PCa (HRPCa) remains very heterogeneous with an unacceptable variation in patient outcome after radical prostatectomy, with cancer-specific mortality rates ranging from 4.6% to 20.3% at 10 years’ follow-up. Clearly, we need a better understanding of the tumor biology to enhance the subclassification, enable the identification of lethal PCa, and eventually allow a more precise decision-making regarding treatment. We created a matched case-control study of two clinically identical HRPCa patient groups, both treated with radical prostatectomy but where one developed metastatic recurrence (n=19) and the other did not (n=25), despite very-long-term follow-up. The integrated analysis of copy number aberrations and transcriptome analysis highlighted a focal amplification of 8q22.3 in the metastatic group, associated with a higher expression of antizyme inhibitor 1 (AZIN1) in our cohort. This association of high AZIN1 levels with the metastatic HRPCa phenotype suggests a role for AZIN1 as possible predictor and/or target for metastatic HRPCa. AZIN1 is one of the regulators of the polyamine synthesis, which play a central role in many cellular processes. Our in vitro analyses confirmed that modulation of AZIN1 expression determines both growth and migratory potential of prostate cancer cells. Future experiments are planned to confirm these data in the in vivo setting. RNA sequencing after knockdown of AZIN1 in PCa cells revealed several transcriptional programs that are activated/deactivated upon AZIN1 knockdown. This showed among others a significant upregulation of genes involved in extracellular matrix composition, including genes encoding for subunits of the collagen IV, which is an integral part of the basement membrane. Ongoing experiments focus on identifying the mechanism by which AZIN1 regulates collagen IV expression. Citation Format: Thomas Van den Broeck, Lisa Moris, Thomas Gevaert, Elien Smeets, Stefan Prekovic, Christine Helsen, Hendrik van Poppel, Wouter Everaerts, Christine Buerki, Elai Davicioni, Steven Joniau, Frank Claessens. Genomic analysis of localized prostate cancer identifies AZIN1 as driver of metastatic progression [abstract]. In: Proceedings of the AACR Special Conference: Prostate Cancer: Advances in Basic, Translational, and Clinical Research; 2017 Dec 2-5; Orlando, Florida. Philadelphia (PA): AACR; Cancer Res 2018;78(16 Suppl):Abstract nr B065." @default.
- W2892055825 created "2018-09-27" @default.
- W2892055825 creator A5003671800 @default.
- W2892055825 creator A5005277533 @default.
- W2892055825 creator A5011712632 @default.
- W2892055825 creator A5014582211 @default.
- W2892055825 creator A5023131151 @default.
- W2892055825 creator A5037570217 @default.
- W2892055825 creator A5051474225 @default.
- W2892055825 creator A5060616205 @default.
- W2892055825 creator A5065896666 @default.
- W2892055825 creator A5067177119 @default.
- W2892055825 creator A5078298172 @default.
- W2892055825 creator A5082067671 @default.
- W2892055825 date "2018-08-14" @default.
- W2892055825 modified "2023-09-25" @default.
- W2892055825 title "Abstract B065: Genomic analysis of localized prostate cancer identifies AZIN1 as driver of metastatic progression" @default.
- W2892055825 doi "https://doi.org/10.1158/1538-7445.prca2017-b065" @default.
- W2892055825 hasPublicationYear "2018" @default.
- W2892055825 type Work @default.
- W2892055825 sameAs 2892055825 @default.
- W2892055825 citedByCount "0" @default.
- W2892055825 crossrefType "proceedings-article" @default.
- W2892055825 hasAuthorship W2892055825A5003671800 @default.
- W2892055825 hasAuthorship W2892055825A5005277533 @default.
- W2892055825 hasAuthorship W2892055825A5011712632 @default.
- W2892055825 hasAuthorship W2892055825A5014582211 @default.
- W2892055825 hasAuthorship W2892055825A5023131151 @default.
- W2892055825 hasAuthorship W2892055825A5037570217 @default.
- W2892055825 hasAuthorship W2892055825A5051474225 @default.
- W2892055825 hasAuthorship W2892055825A5060616205 @default.
- W2892055825 hasAuthorship W2892055825A5065896666 @default.
- W2892055825 hasAuthorship W2892055825A5067177119 @default.
- W2892055825 hasAuthorship W2892055825A5078298172 @default.
- W2892055825 hasAuthorship W2892055825A5082067671 @default.
- W2892055825 hasConcept C104317684 @default.
- W2892055825 hasConcept C121608353 @default.
- W2892055825 hasConcept C126322002 @default.
- W2892055825 hasConcept C127716648 @default.
- W2892055825 hasConcept C143998085 @default.
- W2892055825 hasConcept C150194340 @default.
- W2892055825 hasConcept C162317418 @default.
- W2892055825 hasConcept C173396325 @default.
- W2892055825 hasConcept C2776235491 @default.
- W2892055825 hasConcept C2779013556 @default.
- W2892055825 hasConcept C2779466945 @default.
- W2892055825 hasConcept C2780192828 @default.
- W2892055825 hasConcept C502942594 @default.
- W2892055825 hasConcept C54355233 @default.
- W2892055825 hasConcept C71924100 @default.
- W2892055825 hasConcept C86803240 @default.
- W2892055825 hasConceptScore W2892055825C104317684 @default.
- W2892055825 hasConceptScore W2892055825C121608353 @default.
- W2892055825 hasConceptScore W2892055825C126322002 @default.
- W2892055825 hasConceptScore W2892055825C127716648 @default.
- W2892055825 hasConceptScore W2892055825C143998085 @default.
- W2892055825 hasConceptScore W2892055825C150194340 @default.
- W2892055825 hasConceptScore W2892055825C162317418 @default.
- W2892055825 hasConceptScore W2892055825C173396325 @default.
- W2892055825 hasConceptScore W2892055825C2776235491 @default.
- W2892055825 hasConceptScore W2892055825C2779013556 @default.
- W2892055825 hasConceptScore W2892055825C2779466945 @default.
- W2892055825 hasConceptScore W2892055825C2780192828 @default.
- W2892055825 hasConceptScore W2892055825C502942594 @default.
- W2892055825 hasConceptScore W2892055825C54355233 @default.
- W2892055825 hasConceptScore W2892055825C71924100 @default.
- W2892055825 hasConceptScore W2892055825C86803240 @default.
- W2892055825 hasLocation W28920558251 @default.
- W2892055825 hasOpenAccess W2892055825 @default.
- W2892055825 hasPrimaryLocation W28920558251 @default.
- W2892055825 hasRelatedWork W1492563228 @default.
- W2892055825 hasRelatedWork W1707766907 @default.
- W2892055825 hasRelatedWork W1907172454 @default.
- W2892055825 hasRelatedWork W2045315430 @default.
- W2892055825 hasRelatedWork W2158626602 @default.
- W2892055825 hasRelatedWork W2465824079 @default.
- W2892055825 hasRelatedWork W2612981030 @default.
- W2892055825 hasRelatedWork W2888022095 @default.
- W2892055825 hasRelatedWork W2908016561 @default.
- W2892055825 hasRelatedWork W2953501696 @default.
- W2892055825 isParatext "false" @default.
- W2892055825 isRetracted "false" @default.
- W2892055825 magId "2892055825" @default.
- W2892055825 workType "article" @default.