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- W2892057566 abstract "Abstract Single-particle cryogenic electron microscopy (cryo-EM) provides a powerful methodology for structural biologists, but the resolutions typically attained with experimentally determined structures have lagged behind microscope capabilities. Here, we exploit several technical advances to improve resolution, including per-particle contrast transfer function (CTF) refinement and correction for Ewald sphere curvature. The latter is demonstrated with several experimental samples and should become more standard as resolutions increase or at lower microscope accelerating voltages. The combined application of the described methods to micrographs recorded on a Titan Krios enables structure determination at ~1.86-Å resolution of an adeno-associated virus serotype 2 variant (AAV2), an important gene-delivery vehicle. The resulting structural details provide an improved model for understanding the biology of AAV that will guide future vector development for gene therapy." @default.
- W2892057566 created "2018-09-27" @default.
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- W2892057566 date "2018-09-07" @default.
- W2892057566 modified "2023-10-16" @default.
- W2892057566 title "Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant" @default.
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- W2892057566 doi "https://doi.org/10.1038/s41467-018-06076-6" @default.
- W2892057566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6128836" @default.
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