FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892058508> ?p ?o ?g. }

• W2892058508 endingPage "782" @default.
• W2892058508 startingPage "772" @default.
• W2892058508 abstract "Abstract Recent research has highlighted the importance of the human microbiome in many human disease and health conditions. Most current microbiome association analyses focus on unrelated samples; such methods are not appropriate for analysis of data collected from more advanced study designs such as longitudinal and pedigree studies, where outcomes can be correlated. Ignoring such correlations can sometimes lead to suboptimal results or even possibly biased conclusions. Thus, new methods to handle correlated outcome data in microbiome association studies are needed. In this paper, we propose the correlated sequence kernel association test (CSKAT) to address such correlations using the linear mixed model. Specifically, random effects are used to account for the outcome correlations and a variance component test is used to examine the microbiome effect. Compared to existing genetic association tests for longitudinal and family samples, we implement a correction procedure to better calibrate the null distribution of the score test statistic to accommodate the small sample size nature of data collected from a typical microbiome study. Comprehensive simulation studies are conducted to demonstrate the validity and efficiency of our method, and we show that CSKAT achieves a higher power than existing methods while correctly controlling the Type I error rate. We also apply our method to a microbiome data set collected from a UK twin study to illustrate its potential usefulness. A free implementation of our method in R software is available at https://github.com/jchen1981/SSKAT ." @default.
• W2892058508 created "2018-09-27" @default.
• W2892058508 creator A5000129649 @default.
• W2892058508 creator A5011038911 @default.
• W2892058508 creator A5013014902 @default.
• W2892058508 creator A5017913887 @default.
• W2892058508 creator A5022433604 @default.
• W2892058508 creator A5065573058 @default.
• W2892058508 creator A5082857859 @default.
• W2892058508 creator A5089400160 @default.
• W2892058508 date "2018-09-15" @default.
• W2892058508 modified "2023-10-17" @default.
• W2892058508 title "A small‐sample kernel association test for correlated data with application to microbiome association studies" @default.
• W2892058508 cites W1516274582 @default.
• W2892058508 cites W1575602452 @default.
• W2892058508 cites W1601337698 @default.
• W2892058508 cites W1951724000 @default.
• W2892058508 cites W1972655542 @default.
• W2892058508 cites W2003472145 @default.
• W2892058508 cites W2013470122 @default.
• W2892058508 cites W2015567271 @default.
• W2892058508 cites W2027146825 @default.
• W2892058508 cites W2037878492 @default.
• W2892058508 cites W2051397417 @default.
• W2892058508 cites W2071103029 @default.
• W2892058508 cites W2071841602 @default.
• W2892058508 cites W2072970694 @default.
• W2892058508 cites W2105937617 @default.
• W2892058508 cites W2118606895 @default.
• W2892058508 cites W2125784987 @default.
• W2892058508 cites W2131186249 @default.
• W2892058508 cites W2149421543 @default.
• W2892058508 cites W2149573313 @default.
• W2892058508 cites W2153931548 @default.
• W2892058508 cites W2163903604 @default.
• W2892058508 cites W2163953557 @default.
• W2892058508 cites W2192043071 @default.
• W2892058508 cites W2395461901 @default.
• W2892058508 cites W2398800349 @default.
• W2892058508 cites W2403573949 @default.
• W2892058508 cites W2462648102 @default.
• W2892058508 cites W2496300846 @default.
• W2892058508 cites W2551552113 @default.
• W2892058508 cites W2561012278 @default.
• W2892058508 cites W2562805374 @default.
• W2892058508 cites W2587374790 @default.
• W2892058508 cites W2593051452 @default.
• W2892058508 cites W2609405928 @default.
• W2892058508 cites W2612324143 @default.
• W2892058508 cites W2647715950 @default.
• W2892058508 cites W2751993817 @default.
• W2892058508 cites W2800300455 @default.
• W2892058508 cites W2949616733 @default.
• W2892058508 cites W2951129924 @default.
• W2892058508 doi "https://doi.org/10.1002/gepi.22160" @default.
• W2892058508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30218543" @default.
• W2892058508 hasPublicationYear "2018" @default.
• W2892058508 type Work @default.
• W2892058508 sameAs 2892058508 @default.
• W2892058508 citedByCount "24" @default.
• W2892058508 countsByYear W28920585082019 @default.
• W2892058508 countsByYear W28920585082020 @default.
• W2892058508 countsByYear W28920585082021 @default.
• W2892058508 countsByYear W28920585082022 @default.
• W2892058508 countsByYear W28920585082023 @default.
• W2892058508 crossrefType "journal-article" @default.
• W2892058508 hasAuthorship W2892058508A5000129649 @default.
• W2892058508 hasAuthorship W2892058508A5011038911 @default.
• W2892058508 hasAuthorship W2892058508A5013014902 @default.
• W2892058508 hasAuthorship W2892058508A5017913887 @default.
• W2892058508 hasAuthorship W2892058508A5022433604 @default.
• W2892058508 hasAuthorship W2892058508A5065573058 @default.
• W2892058508 hasAuthorship W2892058508A5082857859 @default.
• W2892058508 hasAuthorship W2892058508A5089400160 @default.
• W2892058508 hasConcept C104317684 @default.
• W2892058508 hasConcept C105795698 @default.
• W2892058508 hasConcept C114614502 @default.
• W2892058508 hasConcept C119857082 @default.
• W2892058508 hasConcept C129848803 @default.
• W2892058508 hasConcept C135763542 @default.
• W2892058508 hasConcept C142853389 @default.
• W2892058508 hasConcept C143121216 @default.
• W2892058508 hasConcept C153209595 @default.
• W2892058508 hasConcept C153720581 @default.
• W2892058508 hasConcept C15744967 @default.
• W2892058508 hasConcept C186413461 @default.
• W2892058508 hasConcept C191988596 @default.
• W2892058508 hasConcept C2994538360 @default.
• W2892058508 hasConcept C33923547 @default.
• W2892058508 hasConcept C41008148 @default.
• W2892058508 hasConcept C542102704 @default.
• W2892058508 hasConcept C54355233 @default.
• W2892058508 hasConcept C60644358 @default.
• W2892058508 hasConcept C74193536 @default.
• W2892058508 hasConcept C86803240 @default.
• W2892058508 hasConcept C89128539 @default.
• W2892058508 hasConcept C96608239 @default.
• W2892058508 hasConceptScore W2892058508C104317684 @default.

• next