FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892062272> ?p ?o ?g. }

• W2892062272 abstract "The present study aimed to investigate the effect of chemokine CC ligand 2 (CCL2) on α‑synuclein‑mediated microglia proliferation and neuronal apoptosis. Primary cultured microglia and primary neurons were isolated and cultured in vitro. Microglia were divided into four groups: The cells in the control group were treated with an identical amount of PBS, whereas the cells in the CCL2 group were cultured in medium containing 0.05 ng/µl CCL2; cells in the α‑synuclein group were treated with medium containing 0.2 ng/µl α‑synuclein; and cells in the CCL2 plus α‑synuclein group were cultured in medium containing 0.05 ng/µl CCL2 and 0.2 ng/µl α‑synuclein. After incubation for 24 h, the proliferation of glial cells, and the level of α‑synuclein in the cells, were measured. The levels of tumor necrosis factor‑α (TNF‑α), interleukin‑1β (IL‑1β) and nitric oxide (NO) in the culture medium were also measured. Levels of cleaved caspase‑3, Akt and phosphorylated (p)‑Akt in neurons treated with primary microglia culture medium in each group were subsequently monitored. The proliferation activity and secretion of TNF‑α, IL‑1β and NO in the CCL2, α‑synuclein and CCL2 plus α‑synuclein groups were significantly higher compared with that in the control group (P<0.05), as were the levels of α‑synuclein (P<0.01). The levels of neuronal apoptosis and cleaved caspase‑3 protein in the CCL2, α‑synuclein and CCL2 plus α‑synuclein groups were also significantly higher compared with that in the control group (P<0.01). Taken together, these results have demonstrated that CCL2 is able to promote α‑synuclein secretion and the apoptosis of neurons induced by α‑synuclein, thus inducing proliferation of the microglia and secretion of TNF‑α, IL‑1β and NO." @default.
• W2892062272 created "2018-09-27" @default.
• W2892062272 creator A5001889524 @default.
• W2892062272 creator A5009008515 @default.
• W2892062272 creator A5011818260 @default.
• W2892062272 creator A5050775877 @default.
• W2892062272 creator A5051962857 @default.
• W2892062272 creator A5063154761 @default.
• W2892062272 creator A5087592842 @default.
• W2892062272 date "2018-09-10" @default.
• W2892062272 modified "2023-10-16" @default.
• W2892062272 title "Effect of chemokine CC ligand 2 (CCL2) on α‑synuclein‑induced microglia proliferation and neuronal apoptosis" @default.
• W2892062272 cites W1595975262 @default.
• W2892062272 cites W1669428397 @default.
• W2892062272 cites W1857419849 @default.
• W2892062272 cites W1892746652 @default.
• W2892062272 cites W1974849442 @default.
• W2892062272 cites W2015283405 @default.
• W2892062272 cites W2023875044 @default.
• W2892062272 cites W2025810715 @default.
• W2892062272 cites W2028586227 @default.
• W2892062272 cites W2048103330 @default.
• W2892062272 cites W2053206193 @default.
• W2892062272 cites W2063459688 @default.
• W2892062272 cites W2069893872 @default.
• W2892062272 cites W2110488126 @default.
• W2892062272 cites W2118103827 @default.
• W2892062272 cites W2126837112 @default.
• W2892062272 cites W2174239077 @default.
• W2892062272 cites W2191467661 @default.
• W2892062272 cites W2612808369 @default.
• W2892062272 cites W811863687 @default.
• W2892062272 doi "https://doi.org/10.3892/mmr.2018.9468" @default.
• W2892062272 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6172395" @default.
• W2892062272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30221727" @default.
• W2892062272 hasPublicationYear "2018" @default.
• W2892062272 type Work @default.
• W2892062272 sameAs 2892062272 @default.
• W2892062272 citedByCount "6" @default.
• W2892062272 countsByYear W28920622722019 @default.
• W2892062272 countsByYear W28920622722020 @default.
• W2892062272 countsByYear W28920622722021 @default.
• W2892062272 countsByYear W28920622722022 @default.
• W2892062272 countsByYear W28920622722023 @default.
• W2892062272 crossrefType "journal-article" @default.
• W2892062272 hasAuthorship W2892062272A5001889524 @default.
• W2892062272 hasAuthorship W2892062272A5009008515 @default.
• W2892062272 hasAuthorship W2892062272A5011818260 @default.
• W2892062272 hasAuthorship W2892062272A5050775877 @default.
• W2892062272 hasAuthorship W2892062272A5051962857 @default.
• W2892062272 hasAuthorship W2892062272A5063154761 @default.
• W2892062272 hasAuthorship W2892062272A5087592842 @default.
• W2892062272 hasBestOaLocation W28920622721 @default.
• W2892062272 hasConcept C101666144 @default.
• W2892062272 hasConcept C13373296 @default.
• W2892062272 hasConcept C153911025 @default.
• W2892062272 hasConcept C17991360 @default.
• W2892062272 hasConcept C185592680 @default.
• W2892062272 hasConcept C190283241 @default.
• W2892062272 hasConcept C203014093 @default.
• W2892062272 hasConcept C2776914184 @default.
• W2892062272 hasConcept C2779830541 @default.
• W2892062272 hasConcept C502942594 @default.
• W2892062272 hasConcept C55493867 @default.
• W2892062272 hasConcept C75217442 @default.
• W2892062272 hasConcept C86803240 @default.
• W2892062272 hasConcept C95444343 @default.
• W2892062272 hasConceptScore W2892062272C101666144 @default.
• W2892062272 hasConceptScore W2892062272C13373296 @default.
• W2892062272 hasConceptScore W2892062272C153911025 @default.
• W2892062272 hasConceptScore W2892062272C17991360 @default.
• W2892062272 hasConceptScore W2892062272C185592680 @default.
• W2892062272 hasConceptScore W2892062272C190283241 @default.
• W2892062272 hasConceptScore W2892062272C203014093 @default.
• W2892062272 hasConceptScore W2892062272C2776914184 @default.
• W2892062272 hasConceptScore W2892062272C2779830541 @default.
• W2892062272 hasConceptScore W2892062272C502942594 @default.
• W2892062272 hasConceptScore W2892062272C55493867 @default.
• W2892062272 hasConceptScore W2892062272C75217442 @default.
• W2892062272 hasConceptScore W2892062272C86803240 @default.
• W2892062272 hasConceptScore W2892062272C95444343 @default.
• W2892062272 hasLocation W28920622721 @default.
• W2892062272 hasLocation W28920622722 @default.
• W2892062272 hasLocation W28920622723 @default.
• W2892062272 hasLocation W28920622724 @default.
• W2892062272 hasOpenAccess W2892062272 @default.
• W2892062272 hasPrimaryLocation W28920622721 @default.
• W2892062272 hasRelatedWork W1989199068 @default.
• W2892062272 hasRelatedWork W2008215152 @default.
• W2892062272 hasRelatedWork W2069015913 @default.
• W2892062272 hasRelatedWork W2215311826 @default.
• W2892062272 hasRelatedWork W2306357121 @default.
• W2892062272 hasRelatedWork W2346283343 @default.
• W2892062272 hasRelatedWork W2964997477 @default.
• W2892062272 hasRelatedWork W3138593302 @default.
• W2892062272 hasRelatedWork W4385396465 @default.
• W2892062272 hasRelatedWork W53278814 @default.
• W2892062272 isParatext "false" @default.
• W2892062272 isRetracted "false" @default.
• W2892062272 magId "2892062272" @default.

• next