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- W2892062445 endingPage "982" @default.
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- W2892062445 abstract "Introduction: Despite the current advances in the discovery of the lung cancer biomarkers and, consequently, in the diagnosis, this pathology continues to be the primary cause of cancer-related death worldwide. In most cases, the illness is diagnosed in an advanced stage, which limits the current treatment options available and reduces the survival rate. Therefore, RNAi-based therapy arises as a promising option to treat lung cancer.Areas covered: This review provides an overview on the exploitation of lung cancer biology to develop RNAi-based therapeutics to be applied in the treatment of lung cancer. Furthermore, the review analyzes the main nanocarriers designed to deliver RNAi molecules and induce antitumoral effects in lung cancer, and provides updated information about current RNAi-based therapeutics for lung cancer in clinical trials.Expert opinion: RNAi-based therapy uses nanocarriers to perform a targeted and efficient delivery of therapeutic genes into lung cancer cells, by taking advantage of the known biomarkers in lung cancer. These therapeutic genes are key regulatory molecules of crucial cellular pathways involved in cell proliferation, migration, and apoptosis. Thereby, the characteristics and functionalization of the nanocarrier and the knowledge of lung cancer biology have direct influence in improving the therapeutic effect of this therapy." @default.
- W2892062445 created "2018-09-27" @default.
- W2892062445 creator A5008458501 @default.
- W2892062445 creator A5011667293 @default.
- W2892062445 creator A5024364625 @default.
- W2892062445 creator A5045596489 @default.
- W2892062445 creator A5063998179 @default.
- W2892062445 date "2018-09-21" @default.
- W2892062445 modified "2023-10-17" @default.
- W2892062445 title "RNAi-based therapeutics for lung cancer: biomarkers, microRNAs, and nanocarriers" @default.
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