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- W2892062975 abstract "Sorting of activated epidermal growth factor receptor (EGFR) into intraluminal vesicles (ILVs) within the multivesicular body (MVB) is an essential step during the down-regulation of the receptor. The machinery that drives EGFR sorting attaches to the cytoplasmic face of the endosome and generates vesicles that bud into the endosome lumen, but somehow escapes encapsulation itself. This machinery is termed the ESCRT (endosomal sorting complexes required for transport) pathway, a series of multi-protein complexes and accessory factors first identified in yeast. Here, we review the yeast ESCRT pathway and describe the corresponding components in mammalian cells that sort EGFR. One of these is His domain protein tyrosine phosphatase (HD-PTP/PTPN23), and we review the interactions involving HD-PTP and ESCRTs. Finally, we describe a working model for how this ESCRT pathway might overcome the intrinsic topographical problem of EGFR sorting to the MVB lumen." @default.
- W2892062975 created "2018-09-27" @default.
- W2892062975 creator A5027367370 @default.
- W2892062975 creator A5050986255 @default.
- W2892062975 date "2018-09-06" @default.
- W2892062975 modified "2023-09-27" @default.
- W2892062975 title "Dissecting the role of His domain protein tyrosine phosphatase/PTPN23 and ESCRTs in sorting activated epidermal growth factor receptor to the multivesicular body" @default.
- W2892062975 cites W1581656442 @default.
- W2892062975 cites W1605689207 @default.
- W2892062975 cites W1838684492 @default.
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- W2892062975 cites W1898920617 @default.
- W2892062975 cites W1965476757 @default.
- W2892062975 cites W1973214920 @default.
- W2892062975 cites W1982915170 @default.
- W2892062975 cites W1988418980 @default.
- W2892062975 cites W1991936310 @default.
- W2892062975 cites W1994683562 @default.
- W2892062975 cites W1996864563 @default.
- W2892062975 cites W1997908150 @default.
- W2892062975 cites W2002872385 @default.
- W2892062975 cites W2007207171 @default.
- W2892062975 cites W2010542476 @default.
- W2892062975 cites W2016923195 @default.
- W2892062975 cites W2018624642 @default.
- W2892062975 cites W2019987740 @default.
- W2892062975 cites W2024502310 @default.
- W2892062975 cites W2027533965 @default.
- W2892062975 cites W2027859676 @default.
- W2892062975 cites W2028651285 @default.
- W2892062975 cites W2032129760 @default.
- W2892062975 cites W2033191472 @default.
- W2892062975 cites W2035178600 @default.
- W2892062975 cites W2041174140 @default.
- W2892062975 cites W2042158953 @default.
- W2892062975 cites W2043952539 @default.
- W2892062975 cites W2051459755 @default.
- W2892062975 cites W2051713962 @default.
- W2892062975 cites W2065164168 @default.
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- W2892062975 cites W2082670593 @default.
- W2892062975 cites W2083456767 @default.
- W2892062975 cites W2083480759 @default.
- W2892062975 cites W2084972502 @default.
- W2892062975 cites W2084983790 @default.
- W2892062975 cites W2088284664 @default.
- W2892062975 cites W2095259985 @default.
- W2892062975 cites W2099674108 @default.
- W2892062975 cites W2099967205 @default.
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- W2892062975 cites W2117670599 @default.
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- W2892062975 cites W2130753161 @default.
- W2892062975 cites W2140408658 @default.
- W2892062975 cites W2140430371 @default.
- W2892062975 cites W2140690761 @default.
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- W2892062975 cites W2153857117 @default.
- W2892062975 cites W2154203178 @default.
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- W2892062975 cites W2404028782 @default.
- W2892062975 cites W2416240773 @default.
- W2892062975 cites W2475087632 @default.
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- W2892062975 cites W2527818273 @default.
- W2892062975 cites W2551500169 @default.
- W2892062975 cites W2624001846 @default.
- W2892062975 cites W2625474333 @default.
- W2892062975 cites W2744528944 @default.
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- W2892062975 doi "https://doi.org/10.1042/bst20170443" @default.
- W2892062975 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6195633" @default.
- W2892062975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30190330" @default.
- W2892062975 hasPublicationYear "2018" @default.
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