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• W2892063709 abstract "Engineered nanoparticles are smaller than 100 nm and designed to improve or creating even new physico-chemical properties. Consequently, toxicological properties of materials may change as size reaches the nm size-range. We examined outcomes related to the central nervous system in the offspring following maternal inhalation exposure to nanosized carbon black particles (Printex 90).Time-mated mice (NMRI) were exposed by inhalation, for 45 min/day to 0, 4.6 or 37 mg/m3 aerosolized carbon black on gestation days 4-18, i.e. for a total of 15 days. Outcomes included maternal lung inflammation (differential cell count in bronchoalveolar lavage fluid and Saa3 mRNA expression in lung tissue), offspring neurohistopathology and behaviour in the open field test.Carbon black exposure did not cause lung inflammation in the exposed females, measured 11 or 28-29 days post-exposure. Glial fibrillary acidic protein (GFAP) expression levels were dose-dependently increased in astrocytes around blood vessels in the cerebral cortex and hippocampus in six weeks old offspring, indicative of reactive astrogliosis. Also enlarged lysosomal granules were observed in brain perivascular macrophages (PVMs) in the prenatally exposed offspring. The number of parvalbumin-positive interneurons and the expression levels of parvalbumin were decreased in the motor and prefrontal cortices at weaning and 120 days of age in the prenatally exposed offspring. In the open field test, behaviour was dose-dependently altered following maternal exposure to Printex 90, at 90 days of age. Prenatally exposed female offspring moved a longer total distance, and especially males spent significantly longer time in the central zone of the maze. In the offspring, the described effects were long-lasting as they were present at all time points investigated.The present study reports for the first time that maternal inhalation exposure to Printex 90 carbon black induced dose-dependent denaturation of PVM and reactive astrocytes, similarly to the findings observed following maternal exposure to Printex 90 by airway instillation. Of note, some of the observed effects have striking similarities with those observed in mouse models of neurodevelopmental disorders." @default.
• W2892063709 created "2018-09-27" @default.
• W2892063709 creator A5016513487 @default.
• W2892063709 creator A5022169033 @default.
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• W2892063709 creator A5077006939 @default.
• W2892063709 creator A5080136004 @default.
• W2892063709 creator A5081232271 @default.
• W2892063709 date "2018-09-10" @default.
• W2892063709 modified "2023-10-15" @default.
• W2892063709 title "Maternal inhalation of carbon black nanoparticles induces neurodevelopmental changes in mouse offspring" @default.
• W2892063709 cites W1479972754 @default.
• W2892063709 cites W1541267199 @default.
• W2892063709 cites W1601370958 @default.
• W2892063709 cites W1793124009 @default.
• W2892063709 cites W1905949689 @default.
• W2892063709 cites W1953465464 @default.
• W2892063709 cites W1972123783 @default.
• W2892063709 cites W1988924673 @default.
• W2892063709 cites W2007229760 @default.
• W2892063709 cites W2014083365 @default.
• W2892063709 cites W2019900112 @default.
• W2892063709 cites W2022230955 @default.
• W2892063709 cites W2023754463 @default.
• W2892063709 cites W2025603247 @default.
• W2892063709 cites W2027953381 @default.
• W2892063709 cites W2031148890 @default.
• W2892063709 cites W2036847201 @default.
• W2892063709 cites W2040408325 @default.
• W2892063709 cites W2042669079 @default.
• W2892063709 cites W2042709322 @default.
• W2892063709 cites W2042898587 @default.
• W2892063709 cites W2050705896 @default.
• W2892063709 cites W2063943133 @default.
• W2892063709 cites W2072131879 @default.
• W2892063709 cites W2072843401 @default.
• W2892063709 cites W2074661552 @default.
• W2892063709 cites W2076644456 @default.
• W2892063709 cites W2078767114 @default.
• W2892063709 cites W2081161499 @default.
• W2892063709 cites W2081720232 @default.
• W2892063709 cites W2083559318 @default.
• W2892063709 cites W2086684376 @default.
• W2892063709 cites W2088683355 @default.
• W2892063709 cites W2092196742 @default.
• W2892063709 cites W2094831632 @default.
• W2892063709 cites W2098540046 @default.
• W2892063709 cites W2099189400 @default.
• W2892063709 cites W2100026340 @default.
• W2892063709 cites W2100314515 @default.
• W2892063709 cites W2102523805 @default.
• W2892063709 cites W2113081633 @default.
• W2892063709 cites W2114477244 @default.
• W2892063709 cites W2122318491 @default.
• W2892063709 cites W2122889851 @default.
• W2892063709 cites W2124717298 @default.
• W2892063709 cites W2124859215 @default.
• W2892063709 cites W2128053399 @default.
• W2892063709 cites W2130451741 @default.
• W2892063709 cites W2130542796 @default.
• W2892063709 cites W2138392219 @default.
• W2892063709 cites W2139474204 @default.
• W2892063709 cites W2141351251 @default.
• W2892063709 cites W2145318781 @default.
• W2892063709 cites W2152638739 @default.
• W2892063709 cites W2155118487 @default.
• W2892063709 cites W2161576159 @default.
• W2892063709 cites W2167279371 @default.
• W2892063709 cites W2167868741 @default.
• W2892063709 cites W2176775892 @default.
• W2892063709 cites W2179660163 @default.
• W2892063709 cites W2194169417 @default.
• W2892063709 cites W2203425094 @default.
• W2892063709 cites W2257585430 @default.
• W2892063709 cites W2258502568 @default.
• W2892063709 cites W2288923216 @default.
• W2892063709 cites W2301631169 @default.
• W2892063709 cites W2320983896 @default.
• W2892063709 cites W2329036516 @default.
• W2892063709 cites W2345745180 @default.
• W2892063709 cites W2362384227 @default.
• W2892063709 cites W2404064029 @default.
• W2892063709 cites W2425645630 @default.
• W2892063709 cites W2461754006 @default.
• W2892063709 cites W2483900161 @default.
• W2892063709 cites W2490214293 @default.
• W2892063709 cites W2515897135 @default.
• W2892063709 cites W2521556950 @default.
• W2892063709 cites W2548570236 @default.
• W2892063709 cites W2561985852 @default.
• W2892063709 cites W2585902254 @default.
• W2892063709 cites W2588351378 @default.
• W2892063709 cites W2595321304 @default.
• W2892063709 cites W2602024874 @default.
• W2892063709 cites W2603460853 @default.
• W2892063709 cites W2605155547 @default.
• W2892063709 cites W2611513048 @default.

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