Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892064481> ?p ?o ?g. }
- W2892064481 abstract "Human endogenous retroviruses (HERV) genome comprises approximately 8% of the human genome. Despite most of HERV genes are mutated, and cannot encode functional proteins, some HERVs genes, such as HERV-W envelope (env) glycoprotein, are known to have intact open reading frames (ORFs), which are expressed in placenta and play important roles in the function of the embryo. HERV-W env, also termed syncytin-1, has been increasingly reported to be involved in the development of schizophrenia, MS and other diseases. Our previous studies showed that syncytin-1 could induce the increase of several schizophrenia-associated genes as diverse as BDNF, NTRK2, DRD3 and GSK3β. Such over-expression of these genes might lead to neuronal dysfunctions, and contribute to the development of schizophrenia. Additionally, specific ion channels such as SK3, which is linked to the regulation of excitability, could be activated by syncytin-1. Abnormalities of these ion channels are also related to schizophrenia. More importantly, we also found that syncytin-1 could induce inflammatory. More lines of independent evidence showed that inflammatory abnormalities played a pivotal role in neuropsychological diseases such as schizophrenia and MS, while the mechanism of inflammatory abnormalities was still not well understood. In this review, we will highlight recent studies showing that syncytin-1 can elevate the expression of numerous inflammatory cytokines and cause inflammatory abnormalities in neural cells. Therefore, we might reveal a novel molecular pathogenic mechanism of syncytin-1 in neuropsychological diseases, such as schizophrenia and multiple sclerosis (MS)." @default.
- W2892064481 created "2018-09-27" @default.
- W2892064481 creator A5001665699 @default.
- W2892064481 creator A5022253303 @default.
- W2892064481 creator A5084635650 @default.
- W2892064481 date "2018-09-07" @default.
- W2892064481 modified "2023-10-15" @default.
- W2892064481 title "Human Endogenous Retroviral Envelope Protein Syncytin-1 and Inflammatory Abnormalities in Neuropsychological Diseases" @default.
- W2892064481 cites W1482980322 @default.
- W2892064481 cites W1491910236 @default.
- W2892064481 cites W1510147084 @default.
- W2892064481 cites W1525388955 @default.
- W2892064481 cites W1540436551 @default.
- W2892064481 cites W1573348274 @default.
- W2892064481 cites W1595314594 @default.
- W2892064481 cites W160081588 @default.
- W2892064481 cites W1966335955 @default.
- W2892064481 cites W1968703969 @default.
- W2892064481 cites W1969683573 @default.
- W2892064481 cites W1975481676 @default.
- W2892064481 cites W1977039417 @default.
- W2892064481 cites W1977365752 @default.
- W2892064481 cites W1979697890 @default.
- W2892064481 cites W1981746740 @default.
- W2892064481 cites W1983991270 @default.
- W2892064481 cites W1984882838 @default.
- W2892064481 cites W1996130123 @default.
- W2892064481 cites W1998496298 @default.
- W2892064481 cites W2010310827 @default.
- W2892064481 cites W2012049170 @default.
- W2892064481 cites W2015656459 @default.
- W2892064481 cites W2017182934 @default.
- W2892064481 cites W2018262098 @default.
- W2892064481 cites W2026690276 @default.
- W2892064481 cites W2027835215 @default.
- W2892064481 cites W2033003961 @default.
- W2892064481 cites W2034427457 @default.
- W2892064481 cites W2035545445 @default.
- W2892064481 cites W2042018182 @default.
- W2892064481 cites W2042755650 @default.
- W2892064481 cites W2043127031 @default.
- W2892064481 cites W2043217368 @default.
- W2892064481 cites W2049803576 @default.
- W2892064481 cites W2049866141 @default.
- W2892064481 cites W2054538838 @default.
- W2892064481 cites W2055503327 @default.
- W2892064481 cites W2057661651 @default.
- W2892064481 cites W2060198845 @default.
- W2892064481 cites W2062240346 @default.
- W2892064481 cites W2064118110 @default.
- W2892064481 cites W2065618747 @default.
- W2892064481 cites W2067854433 @default.
- W2892064481 cites W2068011539 @default.
- W2892064481 cites W2068529753 @default.
- W2892064481 cites W2073460357 @default.
- W2892064481 cites W2080038751 @default.
- W2892064481 cites W2082422372 @default.
- W2892064481 cites W2082482079 @default.
- W2892064481 cites W2086080135 @default.
- W2892064481 cites W2087685632 @default.
- W2892064481 cites W2090573547 @default.
- W2892064481 cites W2092763906 @default.
- W2892064481 cites W2094659663 @default.
- W2892064481 cites W2096708262 @default.
- W2892064481 cites W2098234649 @default.
- W2892064481 cites W2103327619 @default.
- W2892064481 cites W2105027649 @default.
- W2892064481 cites W2109572458 @default.
- W2892064481 cites W2115533246 @default.
- W2892064481 cites W2116710635 @default.
- W2892064481 cites W2117171675 @default.
- W2892064481 cites W2117633779 @default.
- W2892064481 cites W2122542523 @default.
- W2892064481 cites W2122581586 @default.
- W2892064481 cites W2123851781 @default.
- W2892064481 cites W2127991992 @default.
- W2892064481 cites W2133760600 @default.
- W2892064481 cites W2135566895 @default.
- W2892064481 cites W2136024338 @default.
- W2892064481 cites W2136325849 @default.
- W2892064481 cites W2138753535 @default.
- W2892064481 cites W2143417442 @default.
- W2892064481 cites W2143729672 @default.
- W2892064481 cites W2145993791 @default.
- W2892064481 cites W2150582595 @default.
- W2892064481 cites W2153914575 @default.
- W2892064481 cites W2156578386 @default.
- W2892064481 cites W2166818025 @default.
- W2892064481 cites W2169259354 @default.
- W2892064481 cites W2170260565 @default.
- W2892064481 cites W2179568988 @default.
- W2892064481 cites W2315937070 @default.
- W2892064481 cites W2318387838 @default.
- W2892064481 cites W2415086588 @default.
- W2892064481 cites W2479570197 @default.
- W2892064481 cites W2535210517 @default.
- W2892064481 cites W2561918301 @default.
- W2892064481 cites W2587082863 @default.
- W2892064481 cites W2606282939 @default.
- W2892064481 cites W2728023867 @default.