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• W2892065055 abstract "We evaluated the effects of two single-nucleotide polymorphisms on UA concentrations in the first decade of life using repeated-measures data.We included all subjects who were followed-up at least once and for whom we had both UA and genotypic data (i.e., 375, 204, 307, and 363 patients aged 3, 5, 7, and 9 years, respectively). All participated in the Ewha Birth and Growth Cohort study. We used a mixed model analysis to estimate the longitudinal association of serum UA concentration due to the rs3825017 (SLC22A12 c. 246C > T) and rs16890979 (SLC2A9 c. 844G > A) genotypes.Overall, the tracking coefficient of UA concentrations in children 3 to 9 years of age was 0.31, and was higher in boys than in girls (0.34 vs. 0.29, respectively). Regarding individual variance, serum UA concentrations decreased as age increased (β = - 0.07, p < 0.05), but there were no significant differences by sex. The effects of rs3825017 on UA concentration were significant in boys, but not in girls. Boys with the T allele of rs3825017 had higher concentrations than their counterparts regardless of the time of follow-up. The rs16890979 genotypes were not significantly associated with serum UA concentration in either sex.This study showed that rs3825017 in the SLC22A12 gene was associated with UA concentration in childhood." @default.
• W2892065055 created "2018-09-27" @default.
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• W2892065055 date "2018-09-06" @default.
• W2892065055 modified "2023-10-18" @default.
• W2892065055 title "Long-term effects of the SLC2A9 G844A and SLC22A12 C246T variants on serum uric acid concentrations in children" @default.
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• W2892065055 doi "https://doi.org/10.1186/s12887-018-1272-y" @default.
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