Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892065844> ?p ?o ?g. }
- W2892065844 abstract "Abstract Cutaneous squamous cell carcinoma (cSCC) has a high tumour mutational burden (50 mutations per megabase DNA pair). Here, we combine whole-exome analyses from 40 primary cSCC tumours, comprising 20 well-differentiated and 20 moderately/poorly differentiated tumours, with accompanying clinical data from a longitudinal study of immunosuppressed and immunocompetent patients and integrate this analysis with independent gene expression studies. We identify commonly mutated genes, copy number changes and altered pathways and processes. Comparisons with tumour differentiation status suggest events which may drive disease progression. Mutational signature analysis reveals the presence of a novel signature (signature 32), whose incidence correlates with chronic exposure to the immunosuppressive drug azathioprine. Characterisation of a panel of 15 cSCC tumour-derived cell lines reveals that they accurately reflect the mutational signatures and genomic alterations of primary tumours and provide a valuable resource for the validation of tumour drivers and therapeutic targets." @default.
- W2892065844 created "2018-09-27" @default.
- W2892065844 creator A5003599083 @default.
- W2892065844 creator A5013715394 @default.
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- W2892065844 creator A5050366586 @default.
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- W2892065844 creator A5080997789 @default.
- W2892065844 creator A5082083017 @default.
- W2892065844 creator A5084420015 @default.
- W2892065844 date "2018-09-10" @default.
- W2892065844 modified "2023-10-16" @default.
- W2892065844 title "The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature" @default.
- W2892065844 cites W1523804159 @default.
- W2892065844 cites W1876607480 @default.
- W2892065844 cites W1956871134 @default.
- W2892065844 cites W1969343366 @default.
- W2892065844 cites W1971846249 @default.
- W2892065844 cites W1971941564 @default.
- W2892065844 cites W1973702005 @default.
- W2892065844 cites W1979115864 @default.
- W2892065844 cites W1979286520 @default.
- W2892065844 cites W1979627083 @default.
- W2892065844 cites W1983208687 @default.
- W2892065844 cites W1996222881 @default.
- W2892065844 cites W2006288875 @default.
- W2892065844 cites W2008255210 @default.
- W2892065844 cites W2009720434 @default.
- W2892065844 cites W2016193168 @default.
- W2892065844 cites W2029333325 @default.
- W2892065844 cites W2033830672 @default.
- W2892065844 cites W2046234948 @default.
- W2892065844 cites W2053617035 @default.
- W2892065844 cites W2061272743 @default.
- W2892065844 cites W2065121554 @default.
- W2892065844 cites W2068949125 @default.
- W2892065844 cites W2078982083 @default.
- W2892065844 cites W2080698029 @default.
- W2892065844 cites W2086476872 @default.
- W2892065844 cites W2088293068 @default.
- W2892065844 cites W2088580309 @default.
- W2892065844 cites W2090505632 @default.
- W2892065844 cites W2093745735 @default.
- W2892065844 cites W2094122486 @default.
- W2892065844 cites W2096135843 @default.
- W2892065844 cites W2106608030 @default.
- W2892065844 cites W2115024131 @default.
- W2892065844 cites W2115400932 @default.
- W2892065844 cites W2116294169 @default.
- W2892065844 cites W2119665774 @default.
- W2892065844 cites W2121508665 @default.
- W2892065844 cites W2133223718 @default.
- W2892065844 cites W2141707677 @default.
- W2892065844 cites W2143902340 @default.
- W2892065844 cites W2146244933 @default.
- W2892065844 cites W2146512944 @default.
- W2892065844 cites W2148176413 @default.
- W2892065844 cites W2149926109 @default.
- W2892065844 cites W2150486170 @default.
- W2892065844 cites W2152061559 @default.
- W2892065844 cites W2155943701 @default.
- W2892065844 cites W2157466346 @default.
- W2892065844 cites W2157852151 @default.
- W2892065844 cites W2159987716 @default.
- W2892065844 cites W2160796968 @default.
- W2892065844 cites W2168418784 @default.
- W2892065844 cites W2173818354 @default.
- W2892065844 cites W2182664595 @default.
- W2892065844 cites W2187343514 @default.
- W2892065844 cites W2262016342 @default.
- W2892065844 cites W2285093314 @default.
- W2892065844 cites W2303258473 @default.
- W2892065844 cites W2311076830 @default.
- W2892065844 cites W2345503748 @default.
- W2892065844 cites W2346530374 @default.
- W2892065844 cites W2400463922 @default.
- W2892065844 cites W2411358710 @default.
- W2892065844 cites W2413340136 @default.
- W2892065844 cites W2444327061 @default.
- W2892065844 cites W2510883756 @default.
- W2892065844 cites W2512601254 @default.
- W2892065844 cites W2547187744 @default.
- W2892065844 cites W2578814677 @default.
- W2892065844 cites W2584942793 @default.
- W2892065844 cites W2587693457 @default.
- W2892065844 cites W2626355241 @default.
- W2892065844 cites W2755775794 @default.
- W2892065844 cites W2765107560 @default.
- W2892065844 cites W2782790872 @default.
- W2892065844 cites W2789454942 @default.
- W2892065844 cites W39060158 @default.
- W2892065844 doi "https://doi.org/10.1038/s41467-018-06027-1" @default.