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- W2892067447 abstract "Background: A bulk of data indicates that atrial fibrillation (AF) has serious adverse prognostic implications among patients with myocardial infarction (MI). However, the impact of the quality of vitamin K antagonist (VKA) therapy on the incidence of MI among patients with AF is largely unknown. Patients and Methods: We evaluated the association between the quality of VKA therapy (time in therapeutic range, TTR) and risk of MI in a cohort of 54568 patients using warfarin for AF (FinWAF). In the FinWAF database information from several Finnish nationwide registries are linked through the civil registration number of the patients. Results: The number, crude rate and adjusted hazard ratio (HR) of MI among patients with AF and various TTR levels are presented in Table 1. The risk of MI was significantly higher among patients with TTR<50% than in the reference population (TTR=60-70). In contrast, patients with TTR>80 were less likely to have MI during the mean follow-up of 2.4 years (SD 1.7, range 0.0-5.0). Moreover, the risk of MI was clearly higher among those with previous MI (HR 7.0. 95% confidence limits 6.4-7.8). Conclusions: Our data demonstrated an indirect relationship between TTR values and incidence of MI in patients with AF. This novel finding emphasize the importance of high-quality warfarin management not only with regards to stroke but also to the risk of MI." @default.
- W2892067447 created "2018-09-27" @default.
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- W2892067447 date "2015-11-10" @default.
- W2892067447 modified "2023-09-24" @default.
- W2892067447 title "Abstract 13874: Poor Quality of Warfarin Therapy is Associated With Elevated Risk Of Myocardial Infarction in Patients With Atrial Fibrillation. Results From the FinWAF Registry With 54568 Patients" @default.
- W2892067447 doi "https://doi.org/10.1161/circ.132.suppl_3.13874" @default.
- W2892067447 hasPublicationYear "2015" @default.
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